1-cyclohexyl-2-(N-phenyl-N-ethylamino)ethanol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-cyclohexyl-2-(N-phenyl-N-ethylamino)ethanol
• 英文别名: 1-cyclohexyl-2-(N-ethylanilino)ethanol
• 化学式: C₁₆H₂₅NO
• 分子量: 247.381
• InChiKey: UWFXUMRJPOLPEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(toluene-4-sulfonylmethyl)-aniline 、 2-戊酮 在 samarium diiodide 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 为溶剂， 反应 3.0h， 以80%的产率得到1-cyclohexyl-2-(N-phenyl-N-ethylamino)ethanol
  参考文献：
  名称：

  Tosylmethylamines as “Nonstabilized” α-Aminocarbanion Synthon Equivalents:  Advantages and Limitations

  摘要：

  Tosylmethylamines (1) are advantageous synthon equivalents for ''nonstabilized'' alpha-aminocarbanions of aromatic amines, Clean reactions and high yields are observed provided one-step procedures are utilized: the intermediate ''nonstabilized'' alpha-aminocarbanions are of low stability, Reactions formally involving dianions from bis(tosylmethyl)-substituted amines have also been achieved.

  DOI：

  10.1021/jo970733a

文献信息

• Tosylmethylamines as “Nonstabilized” α-Aminocarbanion Synthon Equivalents:  Advantages and Limitations
  作者：Alan R. Katritzky、Daming Feng、Ming Qi

  DOI：10.1021/jo970733a

  日期：1997.9.1

  Tosylmethylamines (1) are advantageous synthon equivalents for ''nonstabilized'' alpha-aminocarbanions of aromatic amines, Clean reactions and high yields are observed provided one-step procedures are utilized: the intermediate ''nonstabilized'' alpha-aminocarbanions are of low stability, Reactions formally involving dianions from bis(tosylmethyl)-substituted amines have also been achieved.