Fmoc-hydrazine hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-hydrazine hydrochloride
• 英文别名: Fmoc-NHNH2 HCl；9H-fluoren-9-ylmethyl N-aminocarbamate;hydrochloride
• 化学式: C₁₅H₁₄N₂O₂*ClH
• 分子量: 290.749
• InChiKey: DANJJHKOQXKRDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.82
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  64.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  L-亮氨酸叔丁酯盐酸盐 、 Fmoc-hydrazine hydrochloride 在 水 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 生成 Fmoc-azaGly-Leu-OH
  参考文献：
  名称：

  Metastin derivatives and use thereof

  摘要：

  公开号：

  EP2113513B1

文献信息

• Method of inhibiting nonspecific interaction between molecules on solid phase support
  申请人：Tanaka Akito

  公开号：US20060177943A1

  公开（公告）日：2006-08-10

  The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.

  本发明提供了一种抑制分子之间非特异性相互作用的方法，其特征在于在将分子固定到固相载体并分析与固相上特异性相互作用的分子之间的过程中，调节固相载体中固相表面的疏水性质，特别是在将分子固定到固相载体时，交错放置了亲水性间隔物，该方法使得能够抑制分子之间的非特异性相互作用，并减少对固相的非特异性吸附。
• METASTIN DERIVATIVES AND USE THEREOF
  申请人：Kitada Chieko

  公开号：US20090318365A1

  公开（公告）日：2009-12-24

  The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivatives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.

  本发明提供了一种metastin衍生物，其中包含metastin的氨基酸被替代化学基团修饰，从而产生了metastin衍生物，具有出色的血液稳定性，并表现出抑制癌症转移或抑制癌症生长的作用。
• Metastin Derivatives and Use Thereof
  申请人：Kitada Chieko

  公开号：US20080312155A1

  公开（公告）日：2008-12-18

  The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.

  该发明提供了稳定的metastin衍生物，具有优异的生物活性（抑制癌细胞转移的活性，抑制癌细胞生长的活性等）。通过用特定的修饰基团修饰metastin的组成氨基酸，发现比天然的metastin具有更好的血液稳定性等，同时表现出优异的抑制癌细胞转移或抑制癌细胞生长的活性。此外，发现这些metastin衍生物表现出抑制性腺激素分泌、抑制性激素分泌等完全不同于以往所知的效应。
• METHOD OF INHIBITING NONSPECIFIC INTERACTION BETWEEN MOLECULES ON SOLID PHASE SUPPORT
  申请人：Reverse Proteomics Research Institute Co., Ltd

  公开号：EP1553412A1

  公开（公告）日：2005-07-13

  The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.

  本发明提供了一种抑制分子间非特异性相互作用的方法，其特征在于，在将分子固定在固相载体上并分析该分子与固相上与该分子特异性相互作用的分子之间的特异性相互作用的过程中、调节固相载体中固相表面的疏水性，特别是在将分子固定到固相载体上时，在固相载体中插入亲水间隔物，这种方法可以抑制分子之间的非特异性相互作用，减少对固相的非特异性吸附。
• Design and synthesis of novel hydrophilic spacers for the reduction of nonspecific binding proteins on affinity resins
  作者：Takaaki Shiyama、Minoru Furuya、Akira Yamazaki、Tomohiro Terada、Akito Tanaka

  DOI：10.1016/j.bmc.2004.03.052

  日期：2004.6

  Tubulin and actin often bind nonspecifically to affinity chromatography resins, complicating research toward identifying the cellular targets. Reduction of nonspecific binding proteins is important for success in finding such targets. We herein disclose the design, synthesis, and effectiveness in reduction of nonspecific binding proteins, of novel hydrophilic spacers (2-5), which were introduced between matrices and a ligand. Among them, tartaric acid derivative (5) exhibited the most effective reduction of nonspecific binding proteins, whilst maintaining binding of the target protein. Introduction of 5 on TOYOPEARL reduced tubulin and actin by almost 65% and 90% compared to that without the hydrophilic spacer, respectively, with effective binding to the target protein, FKBP12. (C) 2004 Elsevier Ltd. All rights reserved.