3-[3]pyridyl-propionaldehyde-diethylacetal

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-[3]pyridyl-propionaldehyde-diethylacetal
• 英文别名: 3-[3]Pyridyl-propionaldehyd-diaethylacetal；3-(3-pyridyl)propionaldehyde diethyl acetal；3-(3,3-diethoxypropyl)pyridine
• 化学式: C₁₂H₁₉NO₂
• 分子量: 209.288
• InChiKey: KBMJJWZPEXUNHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-甲基吡啶 在 氨 、 sodium amide 作用下， 生成 3-[3]pyridyl-propionaldehyde-diethylacetal
  参考文献：
  名称：

  Wibaut; Hoogzand, 1956, vol. 52, p. 357

  摘要：

  DOI：

文献信息

• An efficient and general synthesis of 3-substituted propionaldehydes using the Suzuki–Miyaura coupling
  作者：Cameron J Cowden、Deborah C Hammond、Brian C Bishop、Karel M.J Brands、Antony J Davies、Ulf-H Dolling、Sarah E Brewer

  DOI：10.1016/j.tetlet.2004.06.053

  日期：2004.8

  An efficient method to prepare 3-substituted propionaldehyde derivatives using a Suzuki–Miyaura coupling is reported. The reaction has been demonstrated on a range of substrates including several where the Heck reaction with allyl alcohol failed to give the desired aldehyde product.

  据报道，使用Suzuki-Miyaura偶联制备3-取代丙醛衍生物的有效方法。该反应已在多种底物上得到证实，包括几种与烯丙醇的Heck反应未能得到所需醛产物的底物。
• Method for producing alkyl-substituted aromatic and heteroaromatic compounds by cross-coupling alkyl boronic acids with aryl-or heteroaryl-halogenides or sulfonates under Pd catalysis in the presence of a ligand
  申请人：Scherer Stefan

  公开号：US20090143586A1

  公开（公告）日：2009-06-04

  The invention relates to a method for producing alkyl-substituted aromatic and heteroaromatic compounds by cross-coupling alkyl boronic acids with aryl- or heteroaryl-halogenides or with aryl- or heteroaryl-sulfonates in the presence of a catalyst and of a Brönsted base in a solvent or solvent mixture.

  该发明涉及一种方法，通过在溶剂或溶剂混合物中，在存在催化剂和布朗斯特德碱的情况下，通过交叉偶联烷基硼酸与芳基或杂环芳基卤化物或芳基或杂环芳基磺酸酯来生产烷基取代的芳香和杂环芳香化合物。
• Use of metal complex compounds as oxidation catalysts
  申请人：Schlingloff Gunther

  公开号：US20060100123A1

  公开（公告）日：2006-05-11

  Use of metal complex compounds of formula (1) [L n Mc m X p ] z Y q wherein Mc is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, n and m are each independently of the other an integer having a value of from 1 to 8, p is an integer having a value of from 0 to 32, z is the charge of the metal complex, Y is a counter-ion, q=z/(charge Y), and L is a ligand of formula (2) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are each independently of the others hydrogen: unsubstituted or substituted C 1 -C 18 alkyl or aryl; cyano; halogen; nitro; —COOR 12 or —SO 3 R 12 wherein R 12 is in each case hydrogen, a cation or unsubstituted or substituted C 1 -C 18 alkyl or aryl: —SR 13 , —SO 12 R 13 or —OR 13 wherein R 13 is in each case hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —NR 14 R 15 ; —(C 1 -C 6 alkylene)-NR 14 R 15 ; —N o R 14 R 15 R 16 ; —(C 1 -C 6 alkylene)-N o R 14 R 15 R 16 ; —N(R) 15 )—(C 1 -C 6 alkylene)-NR 1 R 15 ; —N[(C 1 -C 6 alkylene)-NR 14 R 15 ] 2 ; —N(R 13 )—(C 1 -C 6 alkylene)-N o R 14 R 15 R 16 , —N[C 1 -C 6 alkylene)-N o R 14 R 15 R 16 ] 2 ; —N(R 13 )—N—R 14 R 15 or —N(R 13 )—N o R 14 R 15 R 16: wherein R 13 is as defined above and R 14 , R 15 and R 16 are each independently of the other(s) hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl, or R 14 and R 15 together with the nitrogen atom bonding them form an unsubstituted or substituted 5-, 6- or 7-membered ring which may optionally contain further heterotatoms; with the proviso that (i) at least one of the substituents R 1 —R 11 contains a quaternized atom which is not directly bonded to one of the three pyridine A, B or C and that (ii) Y is neither I′ nor Cl′ in the case that Me is Mn(II), R 1 —R 5 and R 7 —R 11 are hydrogen and R 6 is formula (III) as catalysts for oxidation reactions, and the novel metal complex compounds of formula (1), the novel ligands of formula (2) and their starting materials.

  使用式（1）的金属配合物化合物 [LnMcmXp]zYq，其中Mc是锰、钛、铁、钴、镍或铜，X是配位或桥接基团，n和m分别独立地为1至8的整数，p为0至32的整数，z是金属配合物的电荷，Y是反离子，q=z/（反离子Y的电荷），L是式（2）的配体，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11各自独立地是氢、未取代或取代的C1-C18烷基或芳基、氰、卤素、硝基、-COOR12或-SO3R12，其中R12在每种情况下是氢、阳离子或未取代或取代的C1-C18烷基或芳基：-SR13、-SO12R13或-OR13，其中R13在每种情况下是氢或未取代或取代的C1-C18烷基或芳基；-NR14R15；-（C1-C6烷基）-NR14R15；-NoR14R15R16；-（C1-C6烷基）-NoR14R15R16；-N（R）15）-（C1-C6烷基）-NR1R15；-N [（C1-C6烷基）-NR14R15]2；-N（R13）-（C1-C6烷基）-NoR14R15R16，-N [（C1-C6烷基）-NoR14R15R16]2；-N（R13）-N-R14R15或-N（R13）-NoR14R15R16：其中R13如上所定义，R14、R15和R16各自独立地是氢或未取代或取代的C1-C18烷基或芳基，或者R14和R15连同它们之间的氮原子形成未取代或取代的5、6或7元环，该环可以选择性地含有进一步的杂原子；条件是（i）至少一个取代基R1-R11含有一个季铵化的原子，该原子没有直接与三个吡啶A、B或C之一相键合，并且（ii）在Me为Mn（II），R1-R5和R7-R11为氢，R6为式（III）的情况下，Y既不是I'也不是Cl'，作为氧化反应的催化剂，以及式（1）的新型金属配合物化合物、式（2）的新型配体及其起始材料。
• Crystalline modification of a manganese complex
  申请人：Bachmann Frank

  公开号：US20060079705A1

  公开（公告）日：2006-04-13

  This invention relates to a novel crystal form of the 1:1 manganese (III) complex of N,N′,N″tris[salicylideneaminoethyl]amine, a process for its preparation and the use thereof.

  本发明涉及一种新型晶体形态的1:1锰(III)配合物，该配合物为N，N'，N"三[水杨醛亚胺乙基]胺的配合物，其制备方法以及其用途。
• PROCESS FOR TREATING TEXTILE MATERIALS
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1159388B1

  公开（公告）日：2004-09-08