1-[2-methoxyimino-2-(4-pyrrolidin-1-yl-phenyl)-ethyl]-quinolinium bromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-[2-methoxyimino-2-(4-pyrrolidin-1-yl-phenyl)-ethyl]-quinolinium bromide
• 英文别名: (E)-N-methoxy-1-(4-pyrrolidin-1-ylphenyl)-2-quinolin-1-ium-1-ylethanimine;bromide
• 化学式: Br*C₂₂H₂₄N₃O
• 分子量: 426.356
• InChiKey: MLSRSROQINGCNM-VZXGSGAOSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.78
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  28.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  喹啉 、 2-bromo-1-(4-pyrrolidin-1-yl-phenyl)-ethanone O-methyl oxime 以 丙酮 为溶剂， 以61%的产率得到1-[2-methoxyimino-2-(4-pyrrolidin-1-yl-phenyl)-ethyl]-quinolinium bromide
  参考文献：
  名称：

  Quinolinium salt as a potent inhibitor of lymphocyte apoptosis

  摘要：

  The synthesis of several quinolinium salts and related compounds and their ability to inhibit glucocorticoid-induced apoptosis in murine thymocytes are described. Interestingly, 1-[2-methoxyimino-2-(4-pyrrolidin-1-yl-phenyl)ethyl]quinolinium bromide (11) showed a potent protective effect with an EC50 of 0.013 mu M, which was at least 300-fold more potent than the reference compound pifithrin-alpha. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.047

文献信息

• Apoptosis Inhibitors
  申请人：Carson Dennis A.

  公开号：US20080280903A1

  公开（公告）日：2008-11-13

  The present invention provides compounds that act as selective agents to protect against unintentional cell death or tissue damage and can relieve side effects of cancer treatment such as, for example, oral mucositis, hair loss, diarrhea due to damage to the gastrointestinal epithelium, and myelosuppression. In addition, these compounds can be used to prevent premature cell death when the cell death is caused by signals from damaged cells, for example, signals generated as the result of a traumatic incident or an ischemic episode.

  本发明提供了一种化合物，其作为选择性试剂，可以保护细胞免受意外死亡或组织损伤，并可以缓解癌症治疗的副作用，例如口腔黏膜炎、脱发、由于胃肠上皮损伤引起的腹泻和骨髓抑制。此外，这些化合物还可以用于预防细胞过早死亡，当细胞死亡是由于受损细胞发出的信号引起，例如创伤事件或缺血发作的结果产生的信号。
• WO2006/99301
  申请人：——

  公开号：——

  公开（公告）日：——
• US7816352B2
  申请人：——

  公开号：US7816352B2

  公开（公告）日：2010-10-19