6-[4-(Acetylamino)phenyl]-1,3-dihydro-5-methyl-2H-imidazo[4,5-b]pyridin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-[4-(Acetylamino)phenyl]-1,3-dihydro-5-methyl-2H-imidazo[4,5-b]pyridin-2-one
• 英文别名: N-[4-(5-methyl-2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-6-yl)phenyl]acetamide
• 化学式: C₁₅H₁₄N₄O₂
• 分子量: 282.302
• InChiKey: SCIQCTCPOCQQTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  83.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-(4-aminophenyl)-1,3-dihydro-5-methyl-2H-imidazo[4,5-b]pyridin-2-one 生成 6-[4-(Acetylamino)phenyl]-1,3-dihydro-5-methyl-2H-imidazo[4,5-b]pyridin-2-one
  参考文献：
  名称：

  LESHER, GEORGE Y.;BACON, EDWARD R.;SINGH, BALDEV;KUO, GEE-HONG

  摘要：

  DOI：

文献信息

• Imidazopyridines, compositions and use
  申请人：Sterling Drug Inc.

  公开号：US05010086A1

  公开（公告）日：1991-04-23

  1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula ##STR1## where R.sub.1 and R.sub.3 are hydrogen or lower-alkyl, R.sub.5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4-or 3-pyridinyl, or N-oxides thereof, or phenyl or substituted phenyl.

  具有芳基或杂芳基在6位的1,3-二氢-2H-咪唑[4,5-b]吡啶-2-酮，可用作磷酸二酯酶抑制剂，通过将2-氨基-5-(芳基或杂芳基)吡啶-3-羧酸与二苯基磷酰胺反应制备而成。该化合物的化学式为##STR1##其中R.sub.1和R.sub.3为氢或低碳基，R.sub.5为低碳基或氟化低碳基，Ar为4-或3-吡啶基，或其N-氧化物，或苯基或取代苯基。
• Imidazopyridines, their preparation and use
  申请人：Sterling Drug Inc.

  公开号：US04963561A1

  公开（公告）日：1990-10-16

  Novel 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula ##STR1## where R.sub.1 and R.sub.3 are hydrogen or lower-alkyl, R.sub.5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4- or 3-pyridinyl, or phenyl or substituted phenyl.

  具有芳基或杂环芳基在6位的新型1,3-二氢-2H-咪唑[4,5-b]吡啶-2-酮，可用作磷酸二酯酶抑制剂，通过将2-氨基-5-(芳基或杂环芳基)吡啶-3-羧酸与二苯基磷酰胺反应制备而成。化合物的化学式为##STR1##其中，R.sub.1和R.sub.3为氢或低碳基，R.sub.5为低碳基或氟化低碳基，Ar为4-或3-吡啶基，苯基或取代苯基。
• LESHER, GEORGE Y.;BACON, EDWARD R.;SINGH, BALDEV;KUO, GEE-HONG
  作者：LESHER, GEORGE Y.、BACON, EDWARD R.、SINGH, BALDEV、KUO, GEE-HONG

  DOI：——

  日期：——
• AMIDO COMPOUNDS AS AhR MODULATORS
  申请人：IDEAYA BIOSCIENCES, INC.

  公开号：US20210115016A1

  公开（公告）日：2021-04-22

  Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R 1b , R 2a and R 2b have the meanings provided in the specification.
• US4963561A
  申请人：——

  公开号：US4963561A

  公开（公告）日：1990-10-16