bis(mercapto-n-undecanate)glycerophosphorylcholine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: bis(mercapto-n-undecanate)glycerophosphorylcholine
• 英文别名: [(2R)-2,3-bis(11-sulfanylundecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
• 化学式: C₃₀H₆₀NO₈PS₂
• 分子量: 657.914
• InChiKey: JDGAVOYKBALVDU-MUUNZHRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  42
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  2-(octyldisulfanyl)pyridine 、 bis(mercapto-n-undecanate)glycerophosphorylcholine 以 二氯甲烷 为溶剂， 反应 2.0h， 以2.8 g的产率得到bis(n-octyldithio-n-undecanoate)glycerophosphorylcholine
  参考文献：
  名称：

  一种磷脂化合物及其制备方法

  摘要：

  本发明公开了一种磷脂化合物及其制备方法，其结构通式如下：式中，m是2‑10的正整数，n是7‑15的正整数；该化合物含有易断裂的双硫键，在还原性介质中快速断裂降解。其制备步骤如下：1)三苯甲基保护的巯基正烷酸溶于二甲亚砜中，加入N,N'‑羰基二咪唑、1,8‑二氮杂双环[5.4.0]十一碳‑7‑烯、甘油磷酸胆碱反应，得到双‑三苯甲基巯基正烷酸甘油磷酸胆碱；2)双‑三苯甲基巯基正烷酸甘油磷酸胆碱溶于二氯甲烷中，加入三氟乙酸和三乙基硅烷，反应得到双‑巯基烷酸甘油磷酸胆碱；3)双‑巯基烷酸甘油磷酸胆碱溶于二氯甲烷中，加入正烷基二硫代吡啶，反应后得到双‑正烷基二硫代正烷酸甘油磷酸胆碱。

  公开号：

  CN110256485A
• 作为产物：
  描述：

  甘磷酸胆碱 在 三乙基硅烷 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N'-羰基二咪唑 、 三氟乙酸 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 12.5h， 生成 bis(mercapto-n-undecanate)glycerophosphorylcholine
  参考文献：
  名称：

  一种磷脂化合物及其制备方法

  摘要：

  本发明公开了一种磷脂化合物及其制备方法，其结构通式如下：式中，m是2‑10的正整数，n是7‑15的正整数；该化合物含有易断裂的双硫键，在还原性介质中快速断裂降解。其制备步骤如下：1)三苯甲基保护的巯基正烷酸溶于二甲亚砜中，加入N,N'‑羰基二咪唑、1,8‑二氮杂双环[5.4.0]十一碳‑7‑烯、甘油磷酸胆碱反应，得到双‑三苯甲基巯基正烷酸甘油磷酸胆碱；2)双‑三苯甲基巯基正烷酸甘油磷酸胆碱溶于二氯甲烷中，加入三氟乙酸和三乙基硅烷，反应得到双‑巯基烷酸甘油磷酸胆碱；3)双‑巯基烷酸甘油磷酸胆碱溶于二氯甲烷中，加入正烷基二硫代吡啶，反应后得到双‑正烷基二硫代正烷酸甘油磷酸胆碱。

  公开号：

  CN110256485A

文献信息

• Synthetic nanostructures including nucleic acids and/or other entities
  申请人：Northwestern University

  公开号：US10328026B2

  公开（公告）日：2019-06-25

  Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.

  提供了与纳米结构（包括合成纳米结构）有关的物品、组合物、试剂盒和方法。本文所述的某些实施方案包括具有核壳型排列的结构；例如，纳米结构核可被包括材料（如脂质双分子层）的壳包围，并可包括其他成分（如寡核苷酸）。在某些实施方案中，将这些结构导入受试者体内后，可用于递送核酸和/或调节基因表达。因此，本文所述结构可用于诊断、预防、治疗或控制某些疾病或身体状况。在某些情况下，这些结构既是治疗剂又是诊断剂。
• NANOSTRUCTURES SUITABLE FOR SEQUESTERING CHOLESTEROL
  申请人：North Western University

  公开号：EP2288336B1

  公开（公告）日：2016-12-07
• Nanostructures Suitable for Sequestering Cholesterol and Other Molecules
  申请人：Mirkin Chad A.

  公开号：US20090324706A1

  公开（公告）日：2009-12-31

  Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.
• SYNTHETIC NANOSTRUCTURES INCLUDING NUCLEIC ACIDS AND/OR OTHER ENTITIES
  申请人：Thaxton C. Shad

  公开号：US20130034599A1

  公开（公告）日：2013-02-07

  Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.
• NANOSTRUCTURES SUITABLE FOR SEQUESTERING CHOLESTEROL AND OTHER MOLECULES
  申请人：Northwestern University

  公开号：US20130195759A1

  公开（公告）日：2013-08-01

  Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.