4-OH-MBT

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 4-OH-MBT
• 英文别名: 4-hydroxy-2-mercaptobenzothiazole；4-Hydroxybenzo[d]thiazole-2(3H)-thione；4-hydroxy-3H-1,3-benzothiazole-2-thione
• 化学式: C₇H₅NOS₂
• 分子量: 183.255
• InChiKey: NTWWITFVZYGHPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-OH-MBT 、 6-溴-1-己烯 、 白碳黑 在 溶剂黄146 作用下， 以 四氢呋喃 、 sodium hydroxide 、 dichloromethane-Skellysolve B 、 水 为溶剂， 生成 2-(5-Hexenylthio)-4-benzothiazolol
  参考文献：
  名称：

  Substituted benzothiazoles, benzimidazoles, and benzoxazoles

  摘要：

  本发明提供了一些新颖的取代苯并噻唑、苯并咪唑和苯并噁唑化合物，它们可用作白三烯生物合成的抑制剂和/或脂氧化酶活性的抑制剂和/或哺乳动物代谢中粘液分泌的抑制剂。因此，在医学上需要或希望抑制这些系统的地方可以使用它们。

  公开号：

  US04873346A1
• 作为产物：
  描述：

  4-methoxy-3H-benzothiazole-2-thione 生成 4-OH-MBT
  参考文献：
  名称：

  ANDERSON, DAVID J.

  摘要：

  DOI：

文献信息

• Composition for Sterilization Comprising W-Alkoxyperoxycarboxylic Acid
  申请人：Kawakami Masayuki

  公开号：US20080009549A1

  公开（公告）日：2008-01-10

  A peroxycarboxylic acid represented by the general formula (I): (wherein R 1 represents a substituted or unsubstituted C1-C10 alkyl group, or a substituted or unsubstituted C6-C10 aryl group, L represents a substituted or unsubstituted C2-C12 divalent linking group, or R 1 and L may combine to form a ring) and a composition comprising said peroxycarboxylic acid are provided. Said peroxycarboxylic acid can sterilize a medical apparatus such as endoscope in a short period of time and has no unpleasant smell.

  通用公式（I）表示的过氧羧酸： （其中R1表示取代或未取代的C1-C10烷基或取代或未取代的C6-C10芳基，L表示取代或未取代的C2-C12双价连接基，或R1和L可以结合形成环）以及包含所述过氧羧酸的组合物。所述过氧羧酸可以在短时间内对医疗器械如内窥镜进行灭菌，并且没有令人不愉快的气味。
• Method for preparing aqueous composition for sterilization
  申请人：Fujifilm Corporation

  公开号：EP1803350A2

  公开（公告）日：2007-07-04

  A method for preparing an aqueous composition for sterilization, which comprises the step of mixing an acylimidazole represented by the general formula (II): wherein R represents a substituted or unsubstituted C1-C20 alkyl group, or a substituted or unsubstituted C6-C30 aryl group, with an aqueous solution containing a hydrogen peroxide source to produce a corresponding peroxycarboxylic acid. An aqueous composition for sterilization suitable for sterilization of medical apparatuses such as endoscopes, which can be safely and quickly prepared upon use, and a method for preparing the same are provided.

  一种用于灭菌的水性组合物的制备方法，包括将通式(II)代表的酰基咪唑混合的步骤： 其中R代表取代或未取代的C1-C20烷基，或取代或未取代的C6-C30芳基，与含有过氧化氢源的水溶液混合，生成相应的过氧羧酸。本发明提供了一种适用于内窥镜等医疗器械灭菌的水性灭菌组合物，该组合物可在使用时安全快速地制备，并提供了制备该组合物的方法。
• Homogeneous photodegradation study of 2-mercaptobenzothiazole photocatalysed by sodium decatungstate salts: Kinetics and mechanistic pathways
  作者：A. Allaoui、M.A. Malouki、P. Wong-Wah-Chung

  DOI：10.1016/j.jphotochem.2010.04.010

  日期：2010.5

  The photochemical degradation of a benzothiazole derivative, 2-mercaptobenzothiazole (MBT) has been studied in aqueous solution in the presence of a polyoxometalate (POM): sodium decatungstate salts Na4W10O32 (DTA). In aerated conditions, the photodegradation rate of MBT clearly increased in the presence of DTA by a factor six when compared with the direct photolysis with k(MBT) = 0.25 h(-1) and t(1/2)(MBT)= 2.8 h. For the total comprehension of the degradation mechanism, the oxygen influence has been investigated. Oxygen appeared essential for DTA regeneration, its absence induced a three times inhibition of MBT disappearance and completely stopped the photocatalytic cycle. The main photoproducts were identified with LC-ESI-MS and LC-DAD techniques and using some calculations obtained by B3LYP/6-21G method in Gaussian 4.1 software. All the results allowed to propose a mechanistic pathway. Electron transfer and H atom abstraction processes involving W10O324-center dot excited state species were involved in the degradation. In the primary step of the degradation, the hydroxylation of the aromatic ring leading to four OH-MBT isomers and the formation of disulfide form of MBT were observed. For longer irradiation time, a secondary electron transfer permitted the oxidation of OH-MBT isomers and the formation of sulfoxide derivatives. For prolonged exposure (around 100 h), the complete mineralization was noticed in the presence of sodium decatungstate salts. (C) 2010 Elsevier B.V. All rights reserved.
• ANDERSON, DAVID J.
  作者：ANDERSON, DAVID J.

  DOI：——

  日期：——
• HYDROGEN PEROXIDE DISINFECTING AND STERILIZING COMPOSITIONS
  申请人：Metrex Research Corporation

  公开号：EP0957683A1

  公开（公告）日：1999-11-24