2-[1-(dimethylamino)propyl]phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[1-(dimethylamino)propyl]phenol
• 英文别名: 2-(1-Dimethylamino-propyl)-phenol
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: UOFOICIPJVZYQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[1-(dimethylamino)propyl]phenol 、 异氰酸甲酯 生成 trimethyl-[1-(2-methylcarbamoyloxy-phenyl)-propyl]-ammonium; iodide
  参考文献：
  名称：

  Davies et al., Journal of the Chemical Society, 1947, p. 191,196

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢溴酸 作用下， 生成 2-[1-(dimethylamino)propyl]phenol
  参考文献：
  名称：

  Davies et al., Journal of the Chemical Society, 1947, p. 191,196

  摘要：

  DOI：

文献信息

• Sequential Reaction of Arynes via Insertion into the π-Bond of Amides and Trapping Reaction with Dialkylzincs
  作者：Eito Yoshioka、Shigeru Kohtani、Hideto Miyabe

  DOI：10.1021/ol100387h

  日期：2010.5.7

  The sequential transformation of arynes into ortho-disubstituted arenes is achieved by a one-pot procedure using formamides and dialkylzincs. This reaction proceeded via a route involving the trapping reaction of the formal [2 + 2] cycloaddition adducts or quinone methides generated by the insertion of arynes into the C═O bond of amides.

  通过使用甲酰胺和二烷基锌的一锅法将芳烃顺序转化为邻-二取代的芳烃。该反应通过一种途径进行，该途径涉及通过将芳烃插入酰胺的C═O键中而生成的[2 + 2]环加成甲醛或醌甲基化物的捕获反应。
• Insertion of arynes into the carbon–oxygen double bond of amides and its application into the sequential reactions
  作者：Eito Yoshioka、Hideto Miyabe

  DOI：10.1016/j.tet.2011.10.072

  日期：2012.1

  The reaction of arynes, generated from ortho-(trimethylsilyl)aryl triflates, with the C=O bond of formamides gave salicylaldehyde derivatives via the formation of formal [2+2] adducts. The sequential transformation of arynes into ortho-disubstituted arenes, o-aminoalkylphenols or o-hydroxyalkylphenols, was achieved by one-pot procedure using dialkylzincs. (C) 2011 Elsevier Ltd. All rights reserved.
• Methods and Compositions of Derivatives of Probucol for the Treatment of Diabetes
  申请人：Scott Robert A.D.

  公开号：US20080280979A1

  公开（公告）日：2008-11-13

  This present invention provides methods and pharmaceutical compositions for the treatment or prophylaxis of diabetes and related disorders, comprising the administration of an effective amount of a monoester of probucol, particularly the monosuccinic acid ester, or a pharmaceutically acceptable salt or derivative thereof.
• METHODS AND COMPOSITIONS OF DERIVATIVES OF PROBUCOL FOR THE TREATMENT OF DIABETES
  申请人：Scott Robert A.D.

  公开号：US20120295973A1

  公开（公告）日：2012-11-22

  This present invention provides methods and pharmaceutical compositions for the treatment or prophylaxis of diabetes and related disorders, comprising the administration of an effective amount of a monoester of probucol, particularly the monosuccinic acid ester, or a pharmaceutically acceptable salt or derivative thereof.
• US8252840B2
  申请人：——

  公开号：US8252840B2

  公开（公告）日：2012-08-28