Ethyl (+/-)-3-hydroxy-2,2-dimethyl-3-phenylhexanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl (+/-)-3-hydroxy-2,2-dimethyl-3-phenylhexanoate
• 英文别名: Ethyl 3-hydroxy-2,2-dimethyl-3-phenylhexanoate
• 化学式: C₁₆H₂₄O₃
• mdl: MFCD17339080
• 分子量: 264.365
• InChiKey: DZZPNUSKHDUUJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.562
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-溴-2-甲基丙酸乙酯 、 苯丁酮 在 锌 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 (+/-)-3,3-Dimethyl-4-phenyl-4-propyl-2-oxetanone 、 Ethyl (+/-)-3-hydroxy-2,2-dimethyl-3-phenylhexanoate
  参考文献：
  名称：

  Synthesis of .alpha.,.alpha.,.beta.,.beta.-Tetrasubstituted .beta.-Lactones from Ketones, Ethyl .alpha.-Bromoisobutyrate, and Indium or Zinc. Factors Influencing the .beta.-Lactone Formation in the Electrochemical and the Classical Procedure of the Reformatsky Reaction

  摘要：

  An efficient synthesis of alpha,alpha,beta,beta-tetrasubstituted beta-lactones is achieved by an electrochemically supported Reformatsky reaction of aliphatic and aromatic ketones with ethyl alpha-bromoisobutyrate at a sacrificial indium anode. Under these conditions, in most cases the expected beta-hydroxy esters are formed only in negligible amounts or not at all. beta-Lactones are also obtained with a sacrificial zinc anode or even with indium or zinc powder. The substitution pattern of the reactants, the polarity of the solvent, and the applied metal are recognized as factors influencing the extent of the beta-lactone formation.

  DOI：

  10.1021/jo00090a038

文献信息

• Synthesis of .alpha.,.alpha.,.beta.,.beta.-Tetrasubstituted .beta.-Lactones from Ketones, Ethyl .alpha.-Bromoisobutyrate, and Indium or Zinc. Factors Influencing the .beta.-Lactone Formation in the Electrochemical and the Classical Procedure of the Reformatsky Reaction
  作者：Hans Schick、Ralf Ludwig、Karl-Heinz Schwarz、Katharina Kleiner、Annamarie Kunath

  DOI：10.1021/jo00090a038

  日期：1994.6

  An efficient synthesis of alpha,alpha,beta,beta-tetrasubstituted beta-lactones is achieved by an electrochemically supported Reformatsky reaction of aliphatic and aromatic ketones with ethyl alpha-bromoisobutyrate at a sacrificial indium anode. Under these conditions, in most cases the expected beta-hydroxy esters are formed only in negligible amounts or not at all. beta-Lactones are also obtained with a sacrificial zinc anode or even with indium or zinc powder. The substitution pattern of the reactants, the polarity of the solvent, and the applied metal are recognized as factors influencing the extent of the beta-lactone formation.