2-fluoro-N-(1-phenylethyl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-fluoro-N-(1-phenylethyl)acetamide
• 英文别名: N-fluoroacetylphenylethylamine
• 化学式: C₁₀H₁₂FNO
• 分子量: 181.21
• InChiKey: GJBFDNAZYZRDHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氟代乙酰氯 、 α-苯乙胺 在 氢氧化钾 作用下， 以 乙醚 为溶剂， 反应 5.0h， 以63%的产率得到2-fluoro-N-(1-phenylethyl)acetamide
  参考文献：
  名称：

  Synthesis of some new N-monosubstituted fluoroacetamides

  摘要：

  Twenty new N-monosubstituted fluoroacetamides with potential toxicological proper-ties have been synthesized by acylation of the corresponding amines with fluoroacetyl chloride. The substituents were cycloalkyl or various alkyl (with straight or branched carbon chain) groups. The yields ranged from 50 to 92%.

  DOI：

  10.1016/s0022-1139(00)82416-1

文献信息

• Tropylium-promoted Ritter reactions
  作者：Son H. Doan、Mohanad A. Hussein、Thanh Vinh Nguyen

  DOI：10.1039/d1cc02947a

  日期：——

  used to be one of the most powerful synthetic tools to functionalize alcohols and nitriles, providing valuable N-alkyl amide products. However, this reaction has not been frequently used in modern organic synthesis due to its employment of strongly acidic and harsh reaction conditions, which often lead to complicated side reactions. Herein, we report the development of a new method using salts of the

  Ritter 反应曾经是功能化醇和腈的最强大的合成工具之一，可提供有价值的N-烷基酰胺产品。然而，由于该反应采用强酸性和苛刻的反应条件，往往会导致复杂的副反应，因此在现代有机合成中并未经常使用。在此，我们报告了一种使用 tropylium 离子盐促进 Ritter 反应的新方法的开发。这种方法适用于一系列醇和腈底物，使相应的产品具有良好的产率。该反应方案适用于微波和连续流反应器，为有机合成中的进一步应用提供了有吸引力的机会。
• INHIBITORS OF IAP
  申请人：Cohen Frederick

  公开号：US20100256115A1

  公开（公告）日：2010-10-07

  The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R 1 , R 2 , R 3 , R 4 , R 4 ′, R 5 , R 5 ′, R 6 and R 6 ′ are as described herein.

  该发明提供了一种新型IAP抑制剂，可用作治疗恶性肿瘤的治疗剂，其中该化合物具有一般式I，其中X，Y，A，R1，R2，R3，R4，R4'，R5，R5'，R6和R6'如此描述。
• Methods and compositions for bisubstrate inhibitors of acetyltransferases
  申请人：The Government of the United States of America, Department of Health & Human Services

  公开号：US20020002144A1

  公开（公告）日：2002-01-03

  The present invention provides a method of producing a bisubstrate inhibitor in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell. Further provided is a method of inhibiting the activity of an acetyltransferase in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell under conditions whereby a bisubstrate inhibitor will be produced, thereby inhibiting the activity of the acetyltransferase in the cell.

  本发明提供了一种在细胞中生产双基底抑制剂的方法，包括将细胞中存在的乙酰基转移酶的乙酰基受体底物的烷基化衍生物引入细胞。本发明还提供了一种抑制细胞中乙酰转移酶活性的方法，包括在将产生双基底抑制剂的条件下将细胞中存在的乙酰转移酶的乙酰受体底物的烷基化衍生物导入细胞，从而抑制细胞中乙酰转移酶的活性。
• METHODS AND COMPOSITIONS FOR BISUBSTRATE INHIBITORS OF ACETYLTRANSFERASES
  申请人：The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：EP1212056A1

  公开（公告）日：2002-06-12
• US8110568B2
  申请人：——

  公开号：US8110568B2

  公开（公告）日：2012-02-07