N-[2-(diphenylphosphinoyl)-ethyl]-(1R,2S)-norephedrine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(diphenylphosphinoyl)-ethyl]-(1R,2S)-norephedrine
• 英文别名: (1R,2S)-2-(2-diphenylphosphorylethylamino)-1-phenylpropan-1-ol
• 化学式: C₂₃H₂₆NO₂P
• 分子量: 379.439
• InChiKey: HHANMIMMGOBLNI-CVDCTZTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[2-(diphenylphosphinoyl)-ethyl]-(1R,2S)-norephedrine 在 三氯硅烷 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 3.5h， 以75%的产率得到N-[2-(diphenylphosphino)ethyl]-(1R,2S)-norephedrine
  参考文献：
  名称：

  Mixed donor aminophosphine oxide ligands in ruthenium-catalysed asymmetric transfer hydrogenation reactions

  摘要：

  A number of mixed-donor aminophosphine ligands have been prepared and their activity and selectivity in asymmetric transfer hvdrogenation reactions assessed. Enantioselectivities up to 93% and 80% were achieved for the reduction of acetophenone and propiophenone, respectively. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.05.001
• 作为产物：
  描述：

  去甲麻黄碱 、 (乙烯基-苯基磷酰)苯 以 甲醇 为溶剂， 以82%的产率得到N-[2-(diphenylphosphinoyl)-ethyl]-(1R,2S)-norephedrine
  参考文献：
  名称：

  Mixed donor aminophosphine oxide ligands in ruthenium-catalysed asymmetric transfer hydrogenation reactions

  摘要：

  A number of mixed-donor aminophosphine ligands have been prepared and their activity and selectivity in asymmetric transfer hvdrogenation reactions assessed. Enantioselectivities up to 93% and 80% were achieved for the reduction of acetophenone and propiophenone, respectively. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.05.001

文献信息

• Mixed donor aminophosphine oxide ligands in ruthenium-catalysed asymmetric transfer hydrogenation reactions
  作者：Mohammed S. Rahman、Marco Oliana、King Kuok (Mimi) Hii

  DOI：10.1016/j.tetasy.2004.05.001

  日期：2004.6

  A number of mixed-donor aminophosphine ligands have been prepared and their activity and selectivity in asymmetric transfer hvdrogenation reactions assessed. Enantioselectivities up to 93% and 80% were achieved for the reduction of acetophenone and propiophenone, respectively. (C) 2004 Elsevier Ltd. All rights reserved.