二硫代甲酸二甲酯与三乙胺的化合物 | 65859-44-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 二硫代甲酸二甲酯与三乙胺的化合物
• 英文名称: Triethyl-amine; compound with dimethyl-dithiocarbamic acid
• 英文别名: Triethylammonium dimethyldithiocarbamate；N,N-dimethylcarbamodithioate;triethylazanium
• CAS: 65859-44-1
• 化学式: C₃H₇NS₂*C₆H₁₅N
• 分子量: 222.419
• InChiKey: BKJCFLUMYJMIHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.11
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  39.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  杂氮双环磷酸酯 、 二硫代甲酸二甲酯与三乙胺的化合物 在 lithium chloride 作用下， 以 四氢呋喃 为溶剂， 生成 (4R,5S,6S)-3-Dimethylthiocarbamoylsulfanyl-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
  参考文献：
  名称：

  Novel dithiocarbamate carbapenems1 with anti-MRSA activity

  摘要：

  A new series of carbapenems, in which disubstituted-aminothiocarbonylthio moiety, directly attached to the C-2 position, were prepared and evaluated for their antibacterial potency. These analogs showed potent activity against high-level MRSA, Among them, 9e and 9i were found to exhibit good in vivo efficacy comparable to that of vancomycin, for mouse septicemia model with high-level MRSA. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00272-2
• 作为产物：
  描述：

  二硫化碳 、 二甲胺 、 三乙胺 以 乙腈 为溶剂， 生成 二硫代甲酸二甲酯与三乙胺的化合物
  参考文献：
  名称：

  苯乙炔的无金属三官能化：高效的一锅两步合成吉姆-双（二硫代氨基甲酸酯）

  摘要：

  据报道，通过遵循一锅两步策略对苯乙炔体系进行无金属三官能化来合成苯甲酰双（二硫代氨基甲酸酯）。苯乙炔经历分子溴介导的氧化溴化，然后用新制备的二硫代氨基甲酸盐进行亲核取代，该盐是通过胺和CS 2在三乙胺碱存在下迅速反应而制备的。使用各种仲胺和含有不同取代基的苯乙炔体系制备了一系列偕双(二硫代氨基甲酸酯)。

  DOI：

  10.1039/d3ob00712j

文献信息

• 一种含二硫代氨基甲酸取代基的头孢菌素衍 生物
  申请人：中山大学

  公开号：CN104829632B

  公开（公告）日：2017-09-29

  本发明属于医药技术领域，涉及一种由以下通式I表示的头孢菌素衍生物或其药学上可接受的盐，其中：R1、R2、R3、R4、X均为说明书中所定义；本发明还提供了通式I表示的头孢菌素衍生物的制备方法，以及它们在制备抗感染药物中的应用。
• One-pot two-step dithiocarbamylation of styrenes: metal-free stereoselective synthesis of styrenyl dithiocarbamates
  作者：Manas Mondal、Amit Saha

  DOI：10.1039/d2ob00315e

  日期：——

  Styrenes have been functionalized to produce styrenyl dithiocarbamates by a one-pot two-step procedure without using any metal catalysts. Styrene was transformed into a bromo-derivative, which undergoes a domino nucleophilic substitution followed by elimination in the presence of a dithiocarbamate anion and triethylamine to produce trans-styrenyl dithiocarbamates exclusively. The reaction shows a wide

  苯乙烯已被功能化以通过一锅两步程序生产苯乙烯基二硫代氨基甲酸酯，而无需使用任何金属催化剂。苯乙烯被转化为溴代衍生物，在二硫代氨基甲酸根阴离子和三乙胺存在下进行多米诺亲核取代，然后消除，仅生产反式-苯乙烯基二硫代氨基甲酸根。该反应底物范围广，产物收率高。
• Inorganic-organic composite-treated zinc-plated steel sheet
  申请人：Ishizuka Kiyokazu

  公开号：US20050025991A1

  公开（公告）日：2005-02-03

  The present invention provides an inorganic-organic composite-treated zinc-plated steel sheet whose treated coatings do not contain any chromium and which is excellent in corrosion resistance after degreasing, coating adhesion and electrodeposition coating performance. The inorganic-organic composite-treated zinc-plated steel sheet, which is obtained by forming a zinc phosphate coating, in a coating weight of 0.3 to 5 g/m 2 , on the zinc-plated steel sheet surface and forming thereon a post-treatment coating, in a coating weight of 0.01 to 1 g/m 2 , by using a post-treatment composition containing at least one compound (A) selected from the group consisting of thiocarbonyl group-containing compounds, sulfide group-containing compounds and guanidyl group-containing compounds, an organic resin (B), a crosslinking agent (C) and an inorganic corrosion inhibitor (D).

  本发明提供了一种无机-有机复合处理镀锌钢板，其处理涂层不含铬，在脱脂后的耐腐蚀性、涂层附着力和电沉积涂层性能方面都非常出色。 无机-有机复合处理镀锌钢板是通过形成磷酸锌涂层获得的，涂层重量为 0.3 至 5 g/m 2 在镀锌钢板表面形成涂层重量为 0.3 至 5 克/米 2 的磷酸锌涂层，并在其上形成涂层重量为 0.01 至 1 克/米 2 的后处理涂层。 2 使用后处理组合物，该组合物至少含有一种化合物 (A)，该化合物选自由含硫羰基化合物、含硫化物基团化合物和含鸟苷基团化合物、有机树脂 (B)、交联剂 (C) 和无机缓蚀剂 (D) 组成的组。
• Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors
  作者：Coco N. Kapanda、Giulio G. Muccioli、Geoffray Labar、Jacques H. Poupaert、Didier M. Lambert

  DOI：10.1021/jm901323s

  日期：2009.11.26

  Monoglyceride lipase (MGL) inhibition may offer an approach in treating diseases in which higher 2-arachidonoyglycerol activity would be beneficial. We report here the synthesis and pharmacological evaluation of bis(dialkylaminethiocarbonyl)disulfide derivatives as irreversible MGL inhibitors. Inhibition occurs through interactions with MGL C208 and C242 residues, and these derivatives exhibit high inhibition selectivity over fatty acid amide hydrolase, another endocannabinoid-hydrolyzing enzyme.
• Novel dithiocarbamate carbapenems with anti-MRSA activity
  作者：Norikazu Ohtake、Hideaki Imamura、Hideki Jona、Hideo Kiyonaga、Aya Shimizu、Minoru Moriya、Hiroki Sato、Masato Nakano、Ryosuke Ushijima、Susumu Nakagawa

  DOI：10.1016/s0968-0896(98)00069-8

  日期：1998.7

  A new series of 1 beta-methyl carbapenems, in which a disubstituted-aminothiocarbonylthio moiety was attached to the C-2 position of the carbapenem nucleus, were prepared and evaluated for anti-MRSA activity. These derivatives showed good in vitro antibacterial activity against high-level MRSA, and the finding of good affinity for PBP-2' supported these results. Some of the compounds having favorable protein-binding affinity showed excellent in vivo anti-MRSA activity. (C) 1998 Elsevier Science Ltd. All rights reserved.