O-β-phenethylthionoformate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O-β-phenethylthionoformate
• 英文别名: O-(2-phenylethyl) methanethioate
• 化学式: C₉H₁₀OS
• 分子量: 166.244
• InChiKey: LOEFPMMWFMDKCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  41.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  β-phenylethyl (4-fluorophenyl)thionocarbonate 在 三乙基硼 、 二苯基硅烷 、 氧气 作用下， 以 正己烷 、 苯 为溶剂， 反应 0.5h， 以19%的产率得到乙基苯
  参考文献：
  名称：

  自由基反应的发明。第XXXI部分。二苯硅烷：一种通过醇的硫代羰基衍生物对醇进行脱氧，通过异腈进行脱氨基，以及通过自由基链化学对溴和碘化合物进行脱卤的试剂

  摘要：

  各种thionocarbonates和醇的黄原酸盐和二的-xanthates VIC -diols容易脱氧成相应的烃或烯烃，而溴化物和碘化物与以良好的收率diphenylphenylsilane脱卤。

  DOI：

  10.1016/s0040-4020(01)87198-2

文献信息

• Process for production of amines
  申请人：Terada Masahiro

  公开号：US20070142639A1

  公开（公告）日：2007-06-21

  A process for producing an amine which is characterized by reacting an imine with a nucleophilic compound (except a trialkylsilyl vinyl ether) in the presence of a phosphoric acid derivative represented by the formula (1): wherein A 1 represents a spacer; X 1 and X 2 represent each independently a divalent nonmetal atom or a divalent nonmetal atomic group; and Y 1 is oxygen or sulfur. The invention provides a process by which amines (particularly optically active amines) useful as intermediates of medicines, agricultural chemicals, or the like can be produced without special post-treatment in high yield at high optical purity; and phosphoric acid derivatives (particularly optically active phosphoric acid derivatives) useful in the production of the amines.

  一种生产胺的方法，其特征在于在式（1）所代表的磷酸衍生物存在下，将亚胺与一种亲核化合物（三烷基硅基乙烯醚除外）反应： 其中A1代表一个间隔物；X1和X2分别独立表示二价非金属原子或二价非金属原子团；Y1为氧或硫。该发明提供了一种方法，通过该方法，可以在高光学纯度下高产率地生产用作药品、农药等中间体的胺（特别是光学活性胺），而无需进行特殊的后处理；以及用于生产这些胺的磷酸衍生物（特别是光学活性磷酸衍生物）。
• Homogeneous asymmetric hydrogenation catalyst
  申请人：Shimizu Hideo

  公开号：US20090203927A1

  公开（公告）日：2009-08-13

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种用于均相氢化的有用催化剂，特别是用于均相不对称氢化的催化剂，特别是不对称氢化的催化剂，该催化剂易于获得，在经济性和可操作性方面表现出色，以及一种使用该催化剂产生不饱和化合物的氢化物的方法，特别是使用高产率和光学纯度的该催化剂产生手性活性化合物。
• Substituted optically active disphosphine compound
  申请人：Fujiwara Takahiro

  公开号：US20070073065A1

  公开（公告）日：2007-03-29

  Provided is a method for producing an optically active compound, in more detail, for producing an optically active compound by asymmetric hydrogenation in a high yield and asymmetric yield. The present invention also provides a catalyst for asymmetric synthesis for the above production method, especially a catalyst for asymmetric hydrogenation, containing a transition metal complex. Further, the present invention provides a new diphosphine compound useful as a ligand of the above transition metal complex and a new transition metal complex containing the above diphosphine compound. The present invention relates to a diphosphine compound represented by the following formula (1): a transition metal complex using the compound, a catalyst for asymmetric synthesis comprising the above transition metal complex and a method for producing an optically active compound using the above catalyst for asymmetric synthesis.

  提供了一种制备光学活性化合物的方法，更详细地说，是通过高收率和不对称收率的不对称氢化来制备光学活性化合物。本发明还提供了一种用于上述生产方法的不对称合成催化剂，特别是一种包含过渡金属配合物的不对称氢化催化剂。此外，本发明还提供了一种新的二膦化合物，可用作上述过渡金属配合物的配体，以及一种含有上述二膦化合物的新过渡金属配合物。本发明涉及以下式（1）所表示的二膦化合物，使用该化合物的过渡金属配合物，包括上述过渡金属配合物的不对称合成催化剂以及使用上述不对称合成催化剂制备光学活性化合物的方法。
• HOMOGENEOUS ASYMMETRIC HYDROGENATION CATALYST
  申请人：SHIMIZU Hideo

  公开号：US20110065929A1

  公开（公告）日：2011-03-17

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种有用的均相加氢催化剂，特别是一种用于均相不对称加氢的催化剂，特别是不对称加氢，该催化剂可以相对容易地获得，并且在经济性和可操作性方面表现出色。同时提供一种使用该催化剂高产率和光学纯度地制备不饱和化合物的氢化物，特别是光学活性化合物的方法。
• Homogeneous Asymmetric Hydrogenation Process
  申请人：SHIMIZU Hideo

  公开号：US20100137615A1

  公开（公告）日：2010-06-03

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种有用的均相氢化催化剂，特别是一种用于不对称氢化反应的均相催化剂，该催化剂易于获得，经济实用，易于操作，并且使用该催化剂可以高产率、高光学纯度地制备不饱和化合物的氢化产物，特别是光学活性化合物的氢化产物。