4-ethyl-N-methylpicolinamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-ethyl-N-methylpicolinamide
• 英文别名: 4-ethyl-N-methylpyridine-2-carboxamide
• 化学式: C₉H₁₂N₂O
• 分子量: 164.207
• InChiKey: HRRFUSCPLKIYHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-乙基吡啶 、 N-甲基甲酰胺 在 dipotassium peroxodisulfate 作用下， 反应 12.0h， 以72%的产率得到4-ethyl-N-methylpicolinamide
  参考文献：
  名称：

  Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide

  摘要：

  One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.11.006

文献信息

• Anticancer compounds
  申请人：REGENTS OF THE UNIVERSITY OF MINNESOTA

  公开号：US10357477B2

  公开（公告）日：2019-07-23

  The invention provides compounds having the general formula I: and salts thereof, wherein the variables RA, RB, RC, L1, L2, L3, A, B, C, X, Y, Z, E, m, n, and p have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

  本发明提供了具有通式 I 的化合物： 及其盐类，其中变量 RA、RB、RC、L1、L2、L3、A、B、C、X、Y、Z、E、m、n 和 p 的含义如本文所述，以及含有此类化合物的组合物和使用此类化合物及组合物的方法。
• US9670231B2
  申请人：——

  公开号：US9670231B2

  公开（公告）日：2017-06-06
• [EN] IMIDAZOPIPERAZINONE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS<br/>[FR] INHIBITEURS D'IMIDAZOPIPÉRAZINONE DE PROTÉINES D'ACTIVATION DE LA TRANSCRIPTION
  申请人：UNIV TEXAS

  公开号：WO2019195846A1

  公开（公告）日：2019-10-10

  The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.
• Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide
  作者：Trimbak B. Mete、Ankit Singh、Ramakrishna G. Bhat

  DOI：10.1016/j.tetlet.2017.11.006

  日期：2017.12

  One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol. (C) 2017 Elsevier Ltd. All rights reserved.