7-(methoxymethoxy)-3H-phenoxazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 7-(methoxymethoxy)-3H-phenoxazin-3-one
• 英文别名: 7-(Methoxymethoxy)phenoxazin-3-one
• 化学式: C₁₄H₁₁NO₄
• 分子量: 257.246
• InChiKey: KAMVYNIWUWEKKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-(methoxymethoxy)-3H-phenoxazin-3-one 在 N-碘代丁二酰亚胺 作用下， 以 氯仿 为溶剂， 反应 4.0h， 以87%的产率得到6-iodo-7-(methoxymethoxy)-3H-phenoxazin-3-one
  参考文献：
  名称：

  A hydrogen peroxide responsive resorufin-based phototheranostic agent for selective treatment of cancer cells

  摘要：

  DOI：

  10.1016/j.dyepig.2021.109499
• 作为产物：
  描述：

  试卤灵 、 氯甲基甲基醚 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以65%的产率得到7-(methoxymethoxy)-3H-phenoxazin-3-one
  参考文献：
  名称：

  A hydrogen peroxide responsive resorufin-based phototheranostic agent for selective treatment of cancer cells

  摘要：

  DOI：

  10.1016/j.dyepig.2021.109499

文献信息

• Optical molecular sensors for cytochrome P450 activity
  申请人：Makings Lewis R.

  公开号：US20080125586A1

  公开（公告）日：2008-05-29

  The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the generic structure Y-L-Q, wherein Y is selected from the group consisting of Q as herein defined, saturated C 1 -C 20 alkyl, unsaturated C 1 -C 20 alkenyl, unsaturated C 1 -C 20 alkynyl, substituted saturated C 1 -C 20 alkyl, substituted unsaturated C 1 -C 20 alkenyl, substituted unsaturated C 1 -C 20 alkynyl, C 1 -C 20 cycloalkyl, C 1 -C 20 cycloalkenyl, substituted saturated C 1 -C 20 cycloalkyl, substituted unsaturated C 1 -C 20 cycloalkenyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; L is selected from the group of (—OCR 2 H) p —, wherein for each p, all R 2 are separately selected from the group consisting of a hydrogen atom, saturated C 1 -C 20 alkyl, unsaturated C 1 -C 20 alkenyl, unsaturated C 1 -C 20 alkynyl, substituted saturated C 1 -C 20 alkyl, substituted unsaturated C 1 -C 20 alkenyl, substituted unsaturated C 1 -C 20 alkynyl, C 1 -C 20 cycloalkyl, C 1 -C 20 cycloalkenyl, substituted saturated C 1 -C 20 cycloalkyl, substituted unsaturated C 1 -C 20 cycloalkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and p is a positive integer no greater than twelve; and Q is a chemical moiety that gives rise to optical properties in its hydroxy or hydroxylate, phenol or phenoxide form that are different from the optical properties that arise from its ether form. Most preferably, p is one, R 2 is hydrogen, and Q is the ether form of a phenoxide fluorophore.

  该发明提供了一种化合物，可用作至少一种细胞色素P450酶活性的光学探针或传感器，并提供了使用该化合物筛选候选药物的方法，以及由这些方法鉴定的候选药物。该发明的光学探针是一种具有通用结构Y-L-Q的化合物，其中Y选自以下组：Q（如此处定义），饱和C1-C20烷基，不饱和C1-C20烯基，不饱和C1-C20炔基，取代的饱和C1-C20烷基，取代的不饱和C1-C20烯基，取代的不饱和C1-C20炔基，C1-C20环烷基，C1-C20环烯基，取代的饱和C1-C20环烷基，取代的不饱和C1-C20环烯基，芳基，取代的芳基，杂环芳基和取代的杂环芳基；L选自以下组：（—OCR2H）p—，其中对于每个p，所有R2分别选自以下组：氢原子，饱和C1-C20烷基，不饱和C1-C20烯基，不饱和C1-C20炔基，取代的饱和C1-C20烷基，取代的不饱和C1-C20烯基，取代的不饱和C1-C20炔基，C1-C20环烷基，C1-C20环烯基，取代的饱和C1-C20环烷基，取代的不饱和C1-C20环烯基，芳基，取代的芳基，杂环芳基，取代的杂环芳基，p为不大于12的正整数；Q是一种化学基团，在其羟基或羟基化物，酚或酚酸盐形式下产生不同于其醚形式的光学性质。最好的情况是，p为1，R2为氢，Q是酚酸盐荧光团的醚形式。
• Optical Molecular Sensors for Cytochrome P450 Activity
  申请人：Makings Lewis R.

  公开号：US20100105095A1

  公开（公告）日：2010-04-29

  The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the generic structure Y-L-Q, wherein Y is selected from the group consisting of Q as herein defined, saturated C 1 -C 20 alkyl, unsaturated C 1 -C 20 alkenyl, unsaturated C 1 -C 20 alkynyl, substituted saturated C 1 -C 20 alkyl, substituted unsaturated C 1 -C 20 alkenyl, substituted unsaturated C 1 -C 20 alkynyl, C 1 -C 20 cycloalkyl, C 1 -C 20 cycloalkenyl, substituted saturated C 1 -C 20 cycloalkyl, substituted unsaturated C 1 -C 20 cycloalkenyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; L is selected from the group of (—OCR 2 H) p —, wherein for each p, all R 2 are separately selected from the group consisting of a hydrogen atom, saturated C 1 -C 20 alkyl, unsaturated C 1 -C 20 alkenyl, unsaturated C 1 -C 20 alkynyl, substituted saturated C 1 -C 20 alkyl, substituted unsaturated C 1 -C 20 alkenyl, substituted unsaturated C 1 -C 20 alkynyl, C 1 -C 20 cycloalkyl, C 1 -C 20 cycloalkenyl, substituted saturated C 1 -C 20 cycloalkyl, substituted unsaturated C 1 -C 20 cycloalkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and p is a positive integer no greater than twelve; and Q is a chemical moiety that gives rise to optical properties in its hydroxy or hydroxylate, phenol or phenoxide form that are different from the optical properties that arise from its ether form. Most preferably, p is one, R 2 is hydrogen, and Q is the ether form of a phenoxide fluorophore.

  本发明提供了一种化合物，可用作至少一种细胞色素P450酶的光学探针或传感器，并提供了使用该化合物筛选候选药物的方法，以及通过这些方法鉴定的候选药物。本发明的光学探针是具有通用结构Y-L-Q的化合物，其中Y选自以下组：Q如本文所定义的，饱和的C1-C20烷基，不饱和的C1-C20烯基，不饱和的C1-C20炔基，取代的饱和的C1-C20烷基，取代的不饱和的C1-C20烯基，取代的不饱和的C1-C20炔基，C1-C20环烷基，C1-C20环烯基，取代的饱和的C1-C20环烷基，取代的不饱和的C1-C20环烯基，芳基，取代的芳基，杂环芳基和取代的杂环芳基；L选自以下组：（—OCR2H）p—，其中对于每个p，所有R2分别选自以下组：氢原子，饱和的C1-C20烷基，不饱和的C1-C20烯基，不饱和的C1-C20炔基，取代的饱和的C1-C20烷基，取代的不饱和的C1-C20烯基，取代的不饱和的C1-C20炔基，C1-C20环烷基，C1-C20环烯基，取代的饱和的C1-C20环烷基，取代的不饱和的C1-C20环烯基，芳基，取代的芳基，杂环芳基，取代的杂环芳基，p是不大于12的正整数；Q是一种化学基团，在其羟基或羟基酸盐，酚或酚盐形式下产生与其醚形式产生不同的光学性质。最好是，p为1，R2为氢，Q是酚盐荧光团的醚形式。
• Novel fluorogenic substrates for beta-lactamase gene expression
  申请人：Tsien Y. Roger

  公开号：US20070020715A1

  公开（公告）日：2007-01-25

  Provided are fluorescent substrates β-lactamases and methods of using substrates having the general formulas: or in which where R 1 is H or A is S, O, SO, SO 2 or CH 2 ; X is O; L is a linker; R 2 is hydrogen; R 3 is hydrogen; R 4 is hydrogen; R 5 is hydrogen; R 6 is hydrogen; R 7 is hydrogen; R 8 is hydrogen; R 9 is in which W is a hydrogen, alkyl, substituted heteroalkyl, aryl, a heteroaryl, substituted heteroaryl or a CN; and, S is an integer from 0 to 5; W′ and W″ are independently hydrogen, alkyl, substituted heteroalkyl, aryl, substituted heteroaryl, (═O) or OR 10 ; wherein R 10 is hydrogen, substituted alkyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, heteroaryl; or substituted heteroaryl; and, Y is a dye moiety or a quencher moiety. R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R′ is selected from the group consisting of H, physiologically acceptable salts or metal, ester groups, ammonium cations, —CHR 2 OCO(CH 2 ) n CH 3 , —CHR 2 OCOC(CH 3 ) 3 , acylthiomethyl, acyloxy-alpha-benzyl, deltabutyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, β-morpholinoethyl, dialkylaminoethyl, and dialkylaminocarbonyloxymethyl, in which R 2 is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO 2 and CH 2 ; and Z is a donor fluorescent moiety. Also provided are methods of use of the compounds of the general formulas.
• US7427680B2
  申请人：——

  公开号：US7427680B2

  公开（公告）日：2008-09-23
• US7396926B2
  申请人：——

  公开号：US7396926B2

  公开（公告）日：2008-07-08