1,2-dithiobenzene

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代羰基化合物
• 英文名称: 1,2-dithiobenzene
• 英文别名: Cyclohexa-3,5-diene-1,2-dithione
• 化学式: C₆H₄S₂
• 分子量: 140.23
• InChiKey: XLNMFVSAURQHKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-dithiobenzene 、 2-氯乙醇 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以0.7 g的产率得到1,2-bis(2-hydroxyethylthio)benzene
  参考文献：
  名称：

  WO2021052817A5

  摘要：

  公开号：

  WO2021052817A5

文献信息

• Metallocene compounds and labeled molecules comprising the same for in vivo imaging.
  申请人：Aptenia S.R.L.

  公开号：EP2774930A1

  公开（公告）日：2014-09-10

  The present invention concerns compounds and methods of labeling peptides or other molecules with 18F or 19F or any other suitable radionuclide of use, for example, in PET or NMR in vivo imaging. A targeting molecule such as a protein or a peptide is linked to a substituted metallocene complex which is reacted with the 18F or 19F shortly before performing the PET or NMR in vivo imaging on the patient. The labeled molecule is then used for targeting a cell, tissue, organ or pathogen to be imaged or detected.

  本发明涉及化合物和方法，用于将肽或其他分子标记为18F或19F或任何其他适用的放射性核素，例如PET或NMR体内成像中使用。将靶向分子（如蛋白质或肽）与替代的二茂铁配合物连接，然后在对患者进行PET或NMR体内成像之前不久与18F或19F反应。标记的分子然后用于靶向细胞、组织、器官或待成像或检测的病原体。
• [EN] MONOMERIC AND OLIGOMERIC UNSATURATED VICINAL DITHIOETHERS AND THEIR USE FOR SELECTIVE PALLADIUM (II) SEPARATION FROM SECONDARY RAW MATERIALS<br/>[FR] DITHIOÉTHERS VICINAUX MONOMÉRIQUES ET OLIGOMÉRIQUES INSATURÉS ET LEUR UTILISATION POUR LA SÉPARATION SÉLECTIVE DE PALLADIUM (II) À PARTIR DE MATIÈRES PREMIÈRES SECONDAIRES
  申请人：UNIV POTSDAM

  公开号：WO2013026885A1

  公开（公告）日：2013-02-28

  The present invention relates to unsaturated vicinal dithioethers of general formula (I) wherein n is an integer from 1 to 12, wherein m is 0 or 1, wherein X is selected from formules wherein Y is selected from the group consisting of -CH2,-[-CH2,-O-CH2]3, -CH2- CH2-CH2-, -CH2- CH2-O-, -O-CH2-CH2-, -CH2-CH2-O-CH2-, and -CH2-O-CH2-CH2-; wherein, under the proviso that n is 1, m is 1 and R1 and R2 each are H; wherein, under the proviso that n > 1, R1 and R2 are selected from the group consisting of H, Na, CI, and Br, or R1 and R2 together form a bond making up a cycle. Furthermore the invention relates to mixtures of oligomeric unsaturated dithioethers according to the invention, to the use of the compounds and mixtures according to the invention in the separation of Pd (II) and to supports comprising the dithioethers according to the invention.

  本发明涉及通式(I)的不饱和邻二硫醚，其中n为1至12的整数，m为0或1，X从式中选择，其中Y从以下组成的组中选择：-CH2，-[-CH2，-O-CH2]3，-CH2- CH2-CH2-，-CH2- CH2-O-，-O-CH2-CH2-，-CH2-CH2-O-CH2-，和-CH2-O-CH2-CH2-；在n为1时，m为1且R1和R2各为H；在n>1时，R1和R2从H、Na、Cl和Br的组中选择，或者R1和R2一起形成一个环。此外，本发明涉及根据本发明的寡聚不饱和二硫醚的混合物，以及将这些化合物和混合物用于分离Pd(II)以及包含根据本发明的二硫醚的支持体。
• [EN] INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR<br/>[FR] INHIBITEURS DU FACTEUR D'INHIBITION DE LA MIGRATION DES MACROPHAGES
  申请人：HAMPTON MARK

  公开号：WO2010140902A1

  公开（公告）日：2010-12-09

  The invention provides the use of isothiocyanate and isoselenocyanate compounds for treating diseases and conditions mediated by MIF.

  本发明提供了使用异硫氰酸盐和异硒氰酸盐化合物来治疗由MIF介导的疾病和病症的方法。
• Metallocene Compounds and Labeled Molecules Comprising the Same for In Vivo Imaging
  申请人：APTENIA S.R.L.

  公开号：US20160008495A1

  公开（公告）日：2016-01-14

  The present invention concerns compounds and methods of labeling peptides or other molecules with 18 F or 19 F or any other suitable radionuclide of use, for example, in PET or NMR in vivo imaging. A targeting molecule such as a protein or a peptide is linked to a substituted metallocene complex which is reacted with the 1g F or 19 F shortly before performing the PET or NMR in vivo imaging on the patient. The labeled molecule is then used for targeting a cell, tissue, organ or pathogen to be imaged or detected.

  本发明涉及化合物和方法，用于标记肽或其他分子与18F或19F或任何其他适用的放射性核素，例如PET或NMR在体内成像。定位分子，例如蛋白质或肽，与取代的金属环配合物连接，该金属环配合物在对患者进行PET或NMR体内成像之前不久与1gF或19F反应。标记的分子然后用于定位要成像或检测的细胞、组织、器官或病原体。
• A method of fabricating dithiafulven geminal dithiolate compounds and their selenium analogs
  申请人：International Business Machines Corporation

  公开号：EP0020896A1

  公开（公告）日：1981-01-07

  The invention is directed to novel heterofulvene geminal dithiolate compounds and their selenium and tellurium analogs having the general formula wherein X is selected from S, Se and Te. R is selected from hydrogen, alkyl, aryl, or together forming a ring of carbon or hetero atoms, cyano and dithiocarbonate groups and R1 is selected from alkali, alkaline earth and transition metals, quaternary ammonium, alkyl, acyl, cyclic and heterocyclic groups, or together forming a ring. The novel method of preparing these compounds involves the reaction of a cis-dicyanotetraheterofulvalene derivative with two equivalents of an organic sulfide, selenide or telluride compound, eventually followed by reacting the reaction product with two equivalents of an organic halogenide. The new compounds are key synthetic intermediates for the preparation of tetrathiafulvalene derivatives and tetraselenafulvalene derivatives which are useful in optical printing of conducting patterns, in electrochromic displays and in high resolution lithography.

  本发明涉及具有通式的新型杂富烯宝石级二硫酸盐化合物及其硒和碲类似物。 其中 X 选自 S、Se 和 Te。R 选自氢、烷基、芳基或由碳原子或杂原子、氰基和二硫代碳酸酯基团共同形成的环，R1 选自碱金属、碱土金属和过渡金属、季铵、烷基、酰基、环状基团和杂环基团或共同形成的环。 制备这些化合物的新方法是将顺式二氰基四杂环戊烯衍生物与两当量的有机硫化物、硒化物或碲化物反应，最后再将反应产物与两当量的有机卤化物反应。这些新化合物是制备四噻富戊二烯衍生物和四硒富戊二烯衍生物的关键合成中间体，可用于导电图案的光学印刷、电致变色显示和高分辨率光刻。