1,4-bis(N,N-diphenylcarbamoyl)-trans-2,5-dimethyl-piperazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-bis(N,N-diphenylcarbamoyl)-trans-2,5-dimethyl-piperazine
• 英文别名: 1,4-bis(diphenylcarbamoyl)-trans-2,5-dimethylpiperazine；2,5-Dimethyl-piperazine-1,4-dicarboxylic acid bis-diphenylamide；2,5-dimethyl-1-N,1-N,4-N,4-N-tetraphenylpiperazine-1,4-dicarboxamide
• 化学式: C₃₂H₃₂N₄O₂
• 分子量: 504.632
• InChiKey: IZBDDCUHDIOAAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  47.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二苯氨基甲酰氯 、 2,5-dimethyl-piperazine 在 N,N-二异丙基乙胺 作用下， 以 氯仿 、 水 为溶剂， 以835 mg. (33%)的产率得到1,4-bis(N,N-diphenylcarbamoyl)-trans-2,5-dimethyl-piperazine
  参考文献：
  名称：

  N,N-diacylpiperazines

  摘要：

  通用结构式为： ##STR1## 的二酰基哌嗪是抗高血压、充血性心力衰竭、脑血管、认知和中枢神经系统疾病治疗中对 AT.sub.1 和 AT.sub.2 受体具有亲和力的抗肾素II（A-II）拮抗剂。

  公开号：

  US05348955A1

文献信息

• METHOD OF TREATMENT OR PROPHYLAXIS OF INFLAMMATORY PAIN
  申请人：Smith Maree Therese

  公开号：US20100292159A1

  公开（公告）日：2010-11-18

  This invention discloses the use of angiotensin II receptor 2 (AT 2 receptor) antagonists for the treatment, prophylaxis, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals and particularly in human subjects. The AT 2 receptor antagonists may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory conditions.
• Method of Treatment or Prophylaxis of Inflammatory Pain
  申请人：Spinifex Pharmaceuticals Pty Ltd

  公开号：US20140142116A1

  公开（公告）日：2014-05-22

  A method of treatment, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals, particularly in human subjects, comprising administering angiotensin II receptor 2 (AT 2 receptor) antagonists is disclosed. The AT 2 receptor antagonist may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory pain.
• METHOD OF TREATMENT OR PROPHYLAXIS INFTAMMATORY PAIN
  申请人：Novartis AG

  公开号：US20160052925A1

  公开（公告）日：2016-02-25

  A method of treatment, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals, particularly in human subjects, comprising administering angiotensin II receptor 2 (AT 2 receptor) antagonists is disclosed. The AT 2 receptor antagonist may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory pain.
• US5292726A
  申请人：——

  公开号：US5292726A

  公开（公告）日：1994-03-08
• US5348955A
  申请人：——

  公开号：US5348955A

  公开（公告）日：1994-09-20