2-(dimethylamino)ethyl 4-[(3,5-dimethylcyclohexyl)oxy]-5-ethyl-6-methyl-pyridine-2(1H)-one-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(dimethylamino)ethyl 4-[(3,5-dimethylcyclohexyl)oxy]-5-ethyl-6-methyl-pyridine-2(1H)-one-3-carboxylate
• 英文别名: 2-(diethylamino)ethyl 4-(3,5-dimethylcyclohexyl)oxy-5-ethyl-6-methyl-2-oxo-1H-pyridine-3-carboxylate
• 化学式: C₂₃H₃₈N₂O₄
• 分子量: 406.566
• InChiKey: BZMQFOKHXDGMQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl 4-[(3,5-dimethylcyclohexyl)oxy]-5-ethyl-6-methyl-pyridine-2(1H)-one-3-carboxylate 、 二乙氨基乙醇 在 titanium(IV) isopropylate 作用下， 以60%的产率得到2-(dimethylamino)ethyl 4-[(3,5-dimethylcyclohexyl)oxy]-5-ethyl-6-methyl-pyridine-2(1H)-one-3-carboxylate
  参考文献：
  名称：

  2-pyridinone derivatives, having HIV inhibiting properties

  摘要：

  本发明涉及2-吡啶酮衍生物，更具体地涉及通式I中的5-乙基-6-甲基-2-吡啶酮衍生物，它们抑制人类免疫缺陷病毒类型1（HIV-1）的复制，因此在治疗获得性免疫缺陷综合症（AIDS）方面具有重要意义。本发明还涉及所述化合物的合成及其在治疗AIDS和HIV-1病毒感染时与其他药物剂使用的用途。

  公开号：

  EP1516873A1

文献信息

• 2-Pyridinone Derivatives, Having Hiv Inhibiting Properties
  申请人：Le Van Kiet

  公开号：US20070275953A1

  公开（公告）日：2007-11-29

  The present invention relates to 2-Pyridinone derivatives, more specifically 5-ethyl-6-methyl-2-pyridinone derivatives, according to general formula I that inhibit human immunodeficiency virus type 1 (HIV-1) replication and are therefore of interest in the treatment of Acquired Immune Deficiency Syndrome (AIDS). The present invention further relates to the synthesis of said compounds and their use, with or without other pharmaceutical agents, in the treatment of AIDS and viral infections by HIV-1.