1-(o-tolyl)pentan-3-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(o-tolyl)pentan-3-one
• 英文别名: 1-o-tolyl-pentan-3-one；1-o-Tolyl-pentan-3-on；1-(2-Methylphenyl)pentan-3-one
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: YPAQKGQZIYBQGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 、 钯 作用下， 生成 1-(o-tolyl)pentan-3-one
  参考文献：
  名称：

  LVIII.—烷基萘的合成。第I部分5-，6-和7-乙基-1-甲基萘

  摘要：

  DOI：

  10.1039/jr9300000423

文献信息

• [RuCl₂(<i>p-</i>cymene)]₂-Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Ketones under Ligand-Free and Neutral Conditions
  作者：Lei Zhang、Xiaomin Xie、Lei Fu、Zhaoguo Zhang

  DOI：10.1021/jo4001367

  日期：2013.4.5

  A simple and efficient Ru-catalyzed conjugate addition reaction of arylboronic acids to α,β-unsaturated ketones under neutral conditions without any additional ligands has been developed. This Ru(II)-catalytic system both fulfilled the inhibition of the β-hydride elimination in the catalytic cycle and minimized the protonolysis of arylboronic acids.

  已开发出在中性条件下无需任何其他配体的简单有效的Ru催化的芳基硼酸与α，β-不饱和酮的Ru催化的共轭加成反应。该Ru（II）催化体系既实现了催化循环中对β-氢化物消除的抑制，又使芳基硼酸的质子分解最小化。
• [EN] BLEACHING COMPOSITIONS WITH SELECTED PERFUMES FOR MASKING BLEACH ODOR<br/>[FR] COMPOSITIONS DE BLANCHIMENT COMPORTANT DES PARFUMS SELECTIONNES POUR MASQUER L'ODEUR DE L'AGENT DE BLANCHIMENT
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：WO1996031590A1

  公开（公告）日：1996-10-10

  (EN) A bleaching composition is provided which comprises: (a) a peroxygen bleaching agent; (b) a bleach activator; and (c) a perfume. The perfume contains, by weight of the perfume, (i) at least about 25 % of a fragance material selected from the group consisting of aldehydes with a molecular weight greater than 200 AMU, esters with a molecular weight above 200 AMU, alcohols with a molecular weight between 120 and 160 AMU and mixtures thereof, wherein at least about 10 % by weight of the fragance material has an Odor Detection Threshold (ODT) value of less than about 100 parts per trillion; and (ii) at least about 1.0 % of an adjunct material with an Odor Detection Threshold (ODT) value of less than about 100 parts per trillion. The perfume is substantially free of halogenated fragance materials and nitromusks.(FR) Composition de blanchiment constituée a) d'un agent de blanchiment au peroxyde, b) d'un activateur de blanchiment, et c) d'un parfum. Le parfum contient une proportion en poids i) d'au moins 25 % environ d'une substance odorante choisie dans le groupe constitué des aldéhydes ayant une masse moléculaire supérieure à 200 u.m.a., des esters ayant une masse moléculaire supérieure à 200 u.m.a., des alcools ayant une masse moléculaire entre 120 et 160 u.m.a. et des mélanges de ces substances, au moins 10 % environ en poids de la substance odorante ayant un seuil de perception olfactive inférieur à environ 100 parties par billion; et ii) d'au moins environ 1,0 % d'un additif ayant un seuil de perception olfactive inférieur à environ 100 parties par billion. Le parfum est sensiblement dépourvu de substances odorantes halogénées et de nitromuscs.

  一种漂白配方，所述配方包括：(a)一个 peroxygen漂白成分；(b)一个漂白促进剂；和(c)一种香味。该香味含有，按照香味本身重量的百分比计算：(i)至少约25%一种选自以下组的香味物质：该组包括分子量大于200 AMU的醛、该分子量大于200 AMU的酯、分子量介于120至160 AMU的醇及其混合物；其中至少约10%的香味物质具有小于约100 parts per trillion的嗅阈 (ODT) 值；和(ii)至少约1.0%一种嗅阈 (ODT) 小于约 100 parts per trillion 的辅助材料。所述香味显著不含卤代香味物质和硝基 musk。
• Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP
  作者：Ryan J. DeLuca、Jennifer L. Edwards、Laura D. Steffens、Brian W. Michel、Xiaoxiao Qiao、Chunyin Zhu、Silas P. Cook、Matthew S. Sigman

  DOI：10.1021/jo302638v

  日期：2013.2.15

  The Pd-catalyzed TBHP-mediated Wacker-type oxidation of internal alkenes is reported. The reaction uses 2(4,5-dihydro-2-oxazolyl)quinoline (Quinox) as ligand and TBHP(aq) as oxidant to deliver single ketone constitutional isomer products in a predictable fashion from electronically biased olefins. This methodology is showcased through its application on an advanced intermediate in the total synthesis of the antimalarial drug artemisinin.
• BLEACHING COMPOSITIONS WITH SELECTED PERFUMES FOR MASKING BLEACH ODOR
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0821723A1

  公开（公告）日：1998-02-04
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：Cidara Therapeutics, Inc.

  公开号：US20210228727A1

  公开（公告）日：2021-07-29

  Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).