N-(2-methyl-1,3-dioxoisoindolin-5-yl)nicotinamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(2-methyl-1,3-dioxoisoindolin-5-yl)nicotinamide
• 英文别名: N-(2-methyl-1,3-dioxoisoindol-5-yl)pyridine-3-carboxamide
• 化学式: C₁₅H₁₁N₃O₃
• 分子量: 281.271
• InChiKey: FGALLZKUIGVDIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  79.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  三氟甲磺酸三甲基硅酯 、 N-(2-methyl-1,3-dioxoisoindolin-5-yl)nicotinamide 、 四乙酰核糖 在 氯化亚砜 作用下， 以 乙腈 、 甲醇 为溶剂， 反应 19.0h， 以29%的产率得到
  参考文献：
  名称：

  WO2021030551A5

  摘要：

  公开号：

  WO2021030551A5

文献信息

• COMPOUNDS AND COMPOSITIONS FOR DIFFERENTIAL MODULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE
  申请人：Metro International Biotech, LLC

  公开号：EP4013766A1

  公开（公告）日：2022-06-22
• [EN] COMPOUNDS AND COMPOSITIONS FOR DIFFERENTIAL MODULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LA MODULATION DIFFÉRENTIELLE DE NICOTINAMIDE ADÉNINE DINUCLÉOTIDE
  申请人：METRO INT BIOTECH LLC

  公开号：WO2021030551A1

  公开（公告）日：2021-02-18

  The invention relates to compounds and compositions for differential modulation of nicotinamide adenine dinucleotide (NAD) in various tissues or cell types. Further, the invention relates to pharmaceutical compositions containing one or more NAD-modulating compounds as an active pharmaceutical ingredient. The invention also relates to methods of making such compounds and compositions. Methods of using such compounds or compositions include administration of such compounds and compositions to promote the increase or maintenance of intracellular levels of nicotinamide adenine dinucleotide (NAD) in healthy cells and tissues thus improving healthy cell and tissue survival. Also included are methods of increasing or maintaining intracellular levels of NAD in selected cells or tissues while simultaneously reducing NAD levels in unhealthy tissue or cells thus reducing the survival of unhealthy cells and tissue.
• WO2021030551A5
  申请人：——

  公开号：WO2021030551A5

  公开（公告）日：2023-08-16