4-aza-1-hydroxymethyl-10-oxa-3,5-dioxo-4-N-(p-nitrophenyl)tricyclo[5.2.1^1.7.0^2.6]dec-8-ene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-aza-1-hydroxymethyl-10-oxa-3,5-dioxo-4-N-(p-nitrophenyl)tricyclo[5.2.1^1.7.0^2.6]dec-8-ene
• 英文别名: 4-(hydroxymethyl)-2-(4-nitrophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione；7-(hydroxymethyl)-2-(4-nitrophenyl)-4,7a-dihydro-3aH-4,7-epoxyisoindole-1,3-dione
• 化学式: C₁₅H₁₂N₂O₆
• 分子量: 316.27
• InChiKey: LKKZWDCIUPUKAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-aza-1-hydroxymethyl-10-oxa-3,5-dioxo-4-N-(p-nitrophenyl)tricyclo[5.2.1^1.7.0^2.6]dec-8-ene 、 六乙基亚磷酸胺 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以99%的产率得到bis(N,N-diethylamido){4-aza-10-oxa-3,5-dioxo-4-N-(p-nitrophenyl)tricyclo[5.2.1^1.7.0^2.6]dec-8-en-1-yl}methylphosphite
  参考文献：
  名称：

  Condensation of nitro- and amino-substituted phenylmaleimides with furfuryl alcohol

  摘要：

  Reaction of nitro- and amino-substituted phenylmaleimides with furfuryl alcohol afforded 4-aza-1-hydroxymethyl-10-oxa-3,5-dioxo-4-N-[nitro(amino)phenyl]tricyclo[5.2.1(1.7).0(2.6)]dec-8-enes. The latter were easily converted into the corresponding phosphites under the action of hexaethyltriamidophosphite.

  DOI：

  10.1134/s1070363215010132
• 作为产物：
  描述：

  糠醇 、 N-(4-硝基苯基)马来酰亚胺 以 苯 为溶剂， 反应 48.0h， 以64%的产率得到4-aza-1-hydroxymethyl-10-oxa-3,5-dioxo-4-N-(p-nitrophenyl)tricyclo[5.2.1^1.7.0^2.6]dec-8-ene
  参考文献：
  名称：

  Condensation of nitro- and amino-substituted phenylmaleimides with furfuryl alcohol

  摘要：

  Reaction of nitro- and amino-substituted phenylmaleimides with furfuryl alcohol afforded 4-aza-1-hydroxymethyl-10-oxa-3,5-dioxo-4-N-[nitro(amino)phenyl]tricyclo[5.2.1(1.7).0(2.6)]dec-8-enes. The latter were easily converted into the corresponding phosphites under the action of hexaethyltriamidophosphite.

  DOI：

  10.1134/s1070363215010132

文献信息

• Condensation of nitro- and amino-substituted phenylmaleimides with furfuryl alcohol
  作者：Yu. N. Mitrasov、A. A. Avryuskaya、O. V. Kondrat’eva

  DOI：10.1134/s1070363215010132

  日期：2015.1

  Reaction of nitro- and amino-substituted phenylmaleimides with furfuryl alcohol afforded 4-aza-1-hydroxymethyl-10-oxa-3,5-dioxo-4-N-[nitro(amino)phenyl]tricyclo[5.2.1(1.7).0(2.6)]dec-8-enes. The latter were easily converted into the corresponding phosphites under the action of hexaethyltriamidophosphite.