N-(3-aminobenzyl)quinazolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(3-aminobenzyl)quinazolin-4-amine
• 英文别名: N-[(3-aminophenyl)methyl]quinazolin-4-amine
• 化学式: C₁₅H₁₄N₄
• 分子量: 250.303
• InChiKey: XIJILFPYFFKOBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(3-aminobenzyl)quinazolin-4-amine 、 对甲氧基苯异氰酸酯 在 三乙胺 作用下， 以 1,2-二氯乙烷 为溶剂， 以27.56%的产率得到N-(4-methoxyphenyl)-N'-(3-(((quinazolin-4-yl)amino)methyl)phenyl)urea
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel quinazolinyl-diaryl urea derivatives as potential anticancer agents

  摘要：

  Through a structure-based molecular hybridization approach, a series of novel quinazolinyl-diaryl urea derivatives were designed, synthesized, and screened for their in vitro antiproliferative activities against three cancer cell lines (HepG2, MGC-803, and A549). Six compounds (7g, 7m, 7o, 8e, 8g, and 8m) showed stronger activity against a certain cell line compared with the positive reference drugs sorafenib and gefitinib. Among the six compounds, 8g exhibited the strongest activity. In particular, compound 8g induced A549 apoptosis, arrested cell cycle at the G0/G1 phase, elevated intracellular reactive oxygen species level, and decreased mitochondrial membrane potential. This compound can also effectively regulate the expression of apoptosis- and cell cycle-related proteins, and influence the Raf/MEK/ERK pathway. Molecular docking and structure activity relationship analyses revealed that it can bind well to the active site of the receptor c-Raf, which was consistent with the biological data. Therefore, compound 8g may be a potent antitumor agent, representing a promising lead for further optimization. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.10.045
• 作为产物：
  描述：

  邻氨基苯甲酸甲酯 在 甲酸 、 三乙胺 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 生成 N-(3-aminobenzyl)quinazolin-4-amine
  参考文献：
  名称：

  Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivatives

  摘要：

  Based on the structural modification of molecular-targeted agent sorafenib, a series of quinazolinylarylurea derivatives were synthesized and evaluated for their anti-proliferative activities against six human cancer cell lines. Compared with other cell lines tested, T24 was more sensitive to most compounds. Compound 7j exhibited the best profile with lower IC50 value and favorable selectivity. In this study, we focused on 7j-induced death forms of T24 cells and tried to elucidate the reason for its potent proliferative inhibitory activity. Compound 7j treatment could trigger three different cell death forms including apoptosis, ferroptosis, and autophagy; which form would occur depended on the concentrations and incubation time of 7j: (1) Lower concentrations within the initial 8 h of 7j treatment led to apoptosis-dependent death. (2) Ferroptosis and autophagy occurred in the case of higher concentrations combining with extended incubation time through effectively regulating the Sxc(-)/GPx4/ROS and PI3K/ Akt/mTOR/ULK1 pathways, respectively. (3) The above death forms were closely associated with intracellular ROS generation and decreased mitochondrial membrane potential induced by 7j. In molecular docking and structure-activity relationship analyses, 7j could bind well to the active site of the corresponding receptor glutathione peroxidase 4 (GPx4). Compound 7j could be a promising lead for molecular-targeted anti-bladder cancer agents' discovery. (C) 2020 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2020.112661

文献信息

• Design, synthesis, crystal structure, and in vitro antibacterial activities of sulfonamide derivatives bearing the 4-aminoquinazoline moiety
  作者：Suran Wan、Nan Wu、Ya Yan、Yehui Yang、Guangmin Tian、Lian An、Xiaoping Bao

  DOI：10.1007/s11030-022-10484-8

  日期：——

  moiety were designed and synthesized, and their structures were fully characterized by 1H NMR, 13C NMR, and HRMS techniques. Among them, the structures of compounds 5A10 and 5B11 were further confirmed through X-ray single-crystal diffraction analyses. The bioassay results indicated that some of the target compounds displayed higher inhibition activities in vitro against the tested phytopathogenic bacteria

  总共设计并合成了66个带有4-氨基喹唑啉部分的磺酰胺衍生物，并通过1 H NMR、13 C NMR和HRMS技术充分表征了它们的结构。其中，化合物5A10和5B11的结构通过X射线单晶衍射分析得到进一步证实。生物测定结果表明，部分目标化合物对受试植物病原菌表现出较高的体外抑制活性。例如，化合物5A26表现出强抗米黄单胞菌 pv 。oryzicola ( Xoc ) 功效 EC 50（半最大有效浓度）值为 30.6 μg/mL，比对照剂双噻唑 (BMT) 活性高两倍多。此外，化合物5B14对植物病原菌Xanthomonas axonopodis pv.具有良好的抗菌作用。柠檬酸( Xac ) 的 EC 50  = 34.5 μg/mL，显着优于对照剂 BMT (71.5 μg/mL)。抗Xoc机理研究表明，化合物5A26通过增加细菌膜的通透性、降低胞外多糖的含量、引发细菌细胞的形态变化来发挥抗菌功效。
• Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivatives
  作者：Jia-Nian Chen、Ting Li、Li Cheng、Tai-Sheng Qin、Ye-Xiang Sun、Chu-Ting Chen、Yue-Zhen He、Guang Liu、Di Yao、Ying Wei、Qiu-Yin Li、Guang-Ji Zhang

  DOI：10.1016/j.ejmech.2020.112661

  日期：2020.11

  Based on the structural modification of molecular-targeted agent sorafenib, a series of quinazolinylarylurea derivatives were synthesized and evaluated for their anti-proliferative activities against six human cancer cell lines. Compared with other cell lines tested, T24 was more sensitive to most compounds. Compound 7j exhibited the best profile with lower IC50 value and favorable selectivity. In this study, we focused on 7j-induced death forms of T24 cells and tried to elucidate the reason for its potent proliferative inhibitory activity. Compound 7j treatment could trigger three different cell death forms including apoptosis, ferroptosis, and autophagy; which form would occur depended on the concentrations and incubation time of 7j: (1) Lower concentrations within the initial 8 h of 7j treatment led to apoptosis-dependent death. (2) Ferroptosis and autophagy occurred in the case of higher concentrations combining with extended incubation time through effectively regulating the Sxc(-)/GPx4/ROS and PI3K/ Akt/mTOR/ULK1 pathways, respectively. (3) The above death forms were closely associated with intracellular ROS generation and decreased mitochondrial membrane potential induced by 7j. In molecular docking and structure-activity relationship analyses, 7j could bind well to the active site of the corresponding receptor glutathione peroxidase 4 (GPx4). Compound 7j could be a promising lead for molecular-targeted anti-bladder cancer agents' discovery. (C) 2020 Elsevier Masson SAS. All rights reserved.
• Design, synthesis, and biological evaluation of novel quinazolinyl-diaryl urea derivatives as potential anticancer agents
  作者：Jia-Nian Chen、Xian-Fu Wang、Ting Li、De-Wen Wu、Xiao-Bo Fu、Guang-Ji Zhang、Xing-Can Shen、Heng-Shan Wang

  DOI：10.1016/j.ejmech.2015.10.045

  日期：2016.1

  Through a structure-based molecular hybridization approach, a series of novel quinazolinyl-diaryl urea derivatives were designed, synthesized, and screened for their in vitro antiproliferative activities against three cancer cell lines (HepG2, MGC-803, and A549). Six compounds (7g, 7m, 7o, 8e, 8g, and 8m) showed stronger activity against a certain cell line compared with the positive reference drugs sorafenib and gefitinib. Among the six compounds, 8g exhibited the strongest activity. In particular, compound 8g induced A549 apoptosis, arrested cell cycle at the G0/G1 phase, elevated intracellular reactive oxygen species level, and decreased mitochondrial membrane potential. This compound can also effectively regulate the expression of apoptosis- and cell cycle-related proteins, and influence the Raf/MEK/ERK pathway. Molecular docking and structure activity relationship analyses revealed that it can bind well to the active site of the receptor c-Raf, which was consistent with the biological data. Therefore, compound 8g may be a potent antitumor agent, representing a promising lead for further optimization. (C) 2015 Elsevier Masson SAS. All rights reserved.