3-isoprenyl-2,4,6-trihydroxybenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-isoprenyl-2,4,6-trihydroxybenzoic acid
• 英文别名: 2,4,6-Trihydroxy-3-(3-methylbut-2-enyl)benzoic acid
• 化学式: C₁₂H₁₄O₅
• 分子量: 238.24
• InChiKey: SATNWNDIAZEASR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.01
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  97.99
• 氢给体数：
  4.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  3-甲基丁-2-烯基膦酰磷酸氢酯 、 2,4,6-三羟基苯甲酸 在 fungal indole prenyltransferase AnaPT 、 二甲基亚砜 、 甘油 、 calcium chloride 作用下， 以 aq. buffer 为溶剂， 反应 6.0h， 生成 3-isoprenyl-2,4,6-trihydroxybenzoic acid
  参考文献：
  名称：

  Friedel–Crafts Alkylation of Acylphloroglucinols Catalyzed by a Fungal Indole Prenyltransferase

  摘要：

  Naturally occurring prenylated acylphloroglucinol derivatives are plant metabolites with diverse biological and pharmacological activities: Prenylation of acylphloroglucinols plays an important role in the formation of these intriguing natural products and is catalyzed in plants by membrane-bound enzymes. In this study, we demonstrate the prenylation of such compounds by a soluble fungal prenyltransferase AnaPT involved in the biosynthesis of prenylated indole alkaloids. The observed activities of AnaPT toward these substrates are Much higher than that of a microsomal fraction containing an overproduced prenyltransferase from the plant hop.

  DOI：

  10.1021/np5009784

文献信息

• Suresh; Rosary Sheela, X. Queen; Kanmani, Asian Journal of Chemistry, <hi>2010</hi>, vol. 22, # 2, p. 965 - 970
  作者：Suresh、Rosary Sheela, X. Queen、Kanmani、Mani、Easwaran, Lalith、Stanley, A. Leo、Ramani, V. Alex

  DOI：——

  日期：——
• Friedel–Crafts Alkylation of Acylphloroglucinols Catalyzed by a Fungal Indole Prenyltransferase
  作者：Kang Zhou、Lena Ludwig、Shu-Ming Li

  DOI：10.1021/np5009784

  日期：2015.4.24

  Naturally occurring prenylated acylphloroglucinol derivatives are plant metabolites with diverse biological and pharmacological activities: Prenylation of acylphloroglucinols plays an important role in the formation of these intriguing natural products and is catalyzed in plants by membrane-bound enzymes. In this study, we demonstrate the prenylation of such compounds by a soluble fungal prenyltransferase AnaPT involved in the biosynthesis of prenylated indole alkaloids. The observed activities of AnaPT toward these substrates are Much higher than that of a microsomal fraction containing an overproduced prenyltransferase from the plant hop.