4-bromo-3,5-difluoro-4'-propyl-1,1'-biphenyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-3,5-difluoro-4'-propyl-1,1'-biphenyl
• 英文别名: 2-Bromo-1,3-difluoro-5-(4-propylphenyl)benzene
• 化学式: C₁₅H₁₃BrF₂
• 分子量: 311.169
• InChiKey: WVSFYQJOKNIGRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3',5'-二氟-4-丙基联苯 在 2,2,6,6-四甲基哌啶 、 正丁基锂 、 溴 作用下， 反应 4.0h， 以95.9%的产率得到4-bromo-3,5-difluoro-4'-propyl-1,1'-biphenyl
  参考文献：
  名称：

  一种芳烃氟邻位金属化的制备方法

  摘要：

  本发明公开了一种芳烃氟邻位金属化的制备方法，一种芳烃氟邻位金属化的制备方法，是将3‑氟‑（烷基环己基苯基）苯加入有机溶剂、催化量的有机胺，混合均匀后，降温至‑50℃以下，滴加锂试剂，保温2~3小时，进行金属化反应，反应毕‑50℃以下加入亲电试剂，与苯基锂进行反应，保温2~3小时，水解后制得2‑氟‑4‑（烷基环己基苯基）苯衍生物，本发明解决了目前生产中有机胺用量大，原材料成本高，产生废水量大，三废处理压力高的问题，有利于工业化生产。

  公开号：

  CN111018892A

文献信息

• THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME
  申请人：Jansen Axel

  公开号：US20120001123A1

  公开（公告）日：2012-01-05

  The present invention relates to thiophene derivatives, to processes and intermediates for the preparation thereof, to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, and to LC media and LC displays comprising same.

  本发明涉及噻吩衍生物，以及其制备的过程和中间体，以及其在光学、电光和电子方面的用途，特别是在液晶（LC）介质和LC显示器中的应用，以及包含它们的LC介质和LC显示器。
• LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES
  申请人：Wittek Michael

  公开号：US20130119312A1

  公开（公告）日：2013-05-16

  The present invention relates to liquid-crystalline media (LC media) comprising thiophene derivatives and to liquid-crystal displays (LC displays) containing these LC media. The media have high optical anisotropy and preferably have a content of thiophene derivatives of 25% by weight or more.

  本发明涉及含有噻吩衍生物的液晶介质（LC介质），以及包含这些LC介质的液晶显示器（LC显示器）。该介质具有高光学各向异性，最好具有25%或更高的噻吩衍生物含量。
• THIOPHENE COMPOUND, LIQUID-CRYSTALLINE MEDIUM AND LIQUID-CRYSTAL DISPLAY COMPRISING THE SAME
  申请人：Merck Patent GmbH

  公开号：EP3763802A1

  公开（公告）日：2021-01-13

  The invention relates to a liquid-crystalline medium, preferably having a nematic phase and dielectric anisotropy of 0.5 or more, which comprises one or more compounds of formula T in which denotes and the other parameters have the meanings given in the text, to the use thereof in an electro-optical display, particularly in an active-matrix display based on the IPS or FFS effect, to displays of this type which contain a liquid-crystalline medium of this type, and to the compounds of formula T and their use for the improvement of the transmission and/or response times of a liquid-crystalline medium which comprises one or more additional mesogenic compounds.

  本发明涉及一种液晶介质，该介质最好具有向列相，介电各向异性为 0.5 或更高，其中包含一种或多种式 T 的化合物。 其中 表示 和其他参数的含义如文中所述、 其在电子-光学显示器中的应用，特别是在基于 IPS 或 FFS 效应的有源矩阵显示器中的应用，在包含此类液晶介质的显示器中的应用，以及式 T 化合物及其在改善包含一种或多种额外介源化合物的液晶介质的透射率和/或响应时间中的应用。
• Thiophene compound, liquid-crystalline medium and liquid-crystal display comprising the same
  申请人：Merck Patent GmbH

  公开号：US11168255B2

  公开（公告）日：2021-11-09

  A liquid-crystalline medium, preferably having a nematic phase and dielectric anisotropy of 0.5 or more, which comprises one or more compounds of formula T in which denotes and the use thereof in an electro-optical display, particularly in an active-matrix display based on the IPS or FFS effect, to displays of this type which contain a liquid-crystalline medium of this type, and to the compounds of formula T and their use for the improvement of the transmission and/or response times of a liquid-crystalline medium which contains one or more additional mesogenic compounds.

  一种液晶介质，最好具有向列相，介电各向异性为 0.5 或更高，其中包含一种或多种式 T 的化合物 其中 表示 及其在电子光学显示器中的应用，特别是在基于 IPS 或 FFS 效应的有源矩阵显示器中的应用，以及在含有此类液晶介质的此类显示器中的应用，还有式 T 化合物及其在改善含有一种或多种额外介源化合物的液晶介质的透射率和/或响应时间方面的应用。
• Synthesis and Properties of Novel Liquid Crystalline Compounds having a Difluoromethyleneoxy Moiety as a Linkage Group
  作者：Shuichi Matsui、Tomoyuki Kondo、Kouki Sago

  DOI：10.1080/15421400490434919

  日期：2004.1

  Novel liquid crystal compounds having a difluoromethyleneoxy group as a linkage group have been prepared by the new synthetic method using dibromo-difluoromethane in good yield. From. the results of physical property measurements; i.e., transition temperature, dielectric anisotropy (Deltaepsilon), birefringence (Deltan) and viscosity, it becomes obvious that the derivatives having 3,5-Difluorophenyl group at the carbon side of difluoramethyleneoxy group ((1) under bar) have high dielectric anisotropy and low viscosity, and the derivatives having 1, 4-cyclohexylene group at the carbon side of difluoromethyleneoxy group ((2) under bar) have good balance of their physical properties. Moreover, (1) under bar and (2) under bar indicate high voltage holding ratio. Therefore, a novel series of the compounds having a difluoromethyleneoxy linkage group is an eminently suitable material that can lower driving voltage and achieve quicker response time of the AM-LCDs.