N-dodecyl-3-methylpyridinium bromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-dodecyl-3-methylpyridinium bromide
• 英文别名: 1-dodecyl-3-methylpyridinium bromide；1-dodecyl-3-methylpyridin-1-ium;bromide
• 化学式: Br*C₁₈H₃₂N
• 分子量: 342.363
• InChiKey: YVGJWJHYWVRNGN-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.21
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-甲基吡啶 、 溴代十二烷 以 甲苯 为溶剂， 反应 6.0h， 生成 N-dodecyl-3-methylpyridinium bromide
  参考文献：
  名称：

  一锅法合成阳离子表面活性剂及其性能：正烷基-3-甲基溴化吡啶鎓

  摘要：

  通过缩合反应合成了三种新的两亲化合物，即正癸基-3-甲基吡啶鎓溴化物（a），正十二烷基-3-甲基吡啶鎓溴化物（b）和正十四烷基-3-甲基吡啶鎓溴化物（c）。用NMR（1 H，13 C）和FTIR光谱技术表征。化合物的胶束化行为已经在乙醇中采用电导法和紫外/可见光谱法进行了研究。发现化合物a，b和c的临界胶束浓度（CMC）值为0.31、0.29和0.27 m mol L -1， 分别。在298-318 K范围内检查了温度对CMC的影响。计算了这些表面活性剂胶束化过程的热力学参数，例如ΔG，ΔH和ΔS。ΔG的负值和ΔH的正值表明了胶束化过程的自发性和吸热性。这些两亲物的抗微生物活性显示出对不同细菌菌株的显着活性。

  DOI：

  10.1007/s11743-016-1817-8

文献信息

• Micellization, surface activities and thermodynamics study of pyridinium-based ionic liquid surfactants in aqueous solution
  作者：Dong Fu、Xiaoru Gao、Bo Huang、Jue Wang、Yao Sun、Weijun Zhang、Kan Kan、Xiaochen Zhang、Yang Xie、Xin Sui

  DOI：10.1039/c9ra04226a

  日期：——

  pyridinium ionic liquids n-alkyl-3-methylpyridinium bromide ([Cnmpy][Br], n: the carbon numbers of hydrophobic tails, n = 12, 14, 16) in aqueous solution were systematically investigated through electronic conductivity measurement, surface tension, and ultraviolet-absorption spectra. The surface chemical parameters and thermodynamics parameters were obtained. The [Cnmpy][Br] ionic liquids exhibit higher

  长链吡啶鎓离子液体n-烷基-3-甲基溴化吡啶鎓 ([C n mpy][Br], n : 疏水尾的碳原子数, n = 12, 14, 16)通过电子电导率测量、表面张力和紫外吸收光谱系统地研究了溶液。获得了表面化学参数和热力学参数。[C n mpy][Br] 离子液体表现出比具有相应烷基链长度的常规表面活性剂更高的表面活性。无机盐（LiBr、NaBr、MgBr 2）、有机醇（C 2 H 5 OH、C还研究了3 H 7 OH、C 4 H 9 OH、C 5 H 11 OH) 和温度对 [C n mpy][Br] 水溶液的临界胶束浓度 (CMC) 值的影响。随着无机盐的添加，CMC 值显着降低。CMC 值在乙醇存在下略有增加，但随着醇链长度的增加而逐渐降低。CMC值随着温度的升高呈现先下降后上升的趋势。热力学参数计算结果表明，[C n mpy][Br]的吸附和胶束化过程都是自发的；[C 12的焓mpy][Br]
• Wide-Antimicrobial Spectrum of Picolinium Salts
  作者：Sarka Salajkova、Marketa Benkova、Jan Marek、Radek Sleha、Lukas Prchal、David Malinak、Rafael Dolezal、Kristina Sepčić、Nina Gunde-Cimerman、Kamil Kuca、Ondrej Soukup

  DOI：10.3390/molecules25092254

  日期：——

  Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C12, C14, C16) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C14 and C16 side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.

  医院感染极大增加了住院患者的发病率，加之不断增长的抗生素抗性，仍然鼓励许多研究人员寻找新型抗菌化合物。通过Menshutkin样反应制备了具有不同烷基链长度（C12、C14、C16）的吡啶盐，并针对它们的生物活性，即亲脂性和临界胶束浓度进行了评估。具有C14和C16侧链的吡啶盐在抗菌效力方面取得了类似甚至更好的结果，与苯扎溴铵相比；值得注意的是，它们的杀真菌效果明显更强。芳香环上甲基取代基的位置似乎不影响抗菌活性，与N-烷基链长度的影响形成对比。同时，吡啶盐对哺乳动物细胞表现出令人满意的低细胞毒性，即低于苯扎溴铵化合物，被认为是安全的。
• Process for preparing di-tert.-butyl dicarbonate
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0468404A2

  公开（公告）日：1992-01-29

  Di-tert.-butyl dicarbonate having a high purity is prepared by reacting alkali metal tert.-butyl carbonate with methanesulfonyl chloride optionally in the presence of a phase transfer catalyst or an aromatic amine.

  高纯度的二碳酸二叔丁酯是通过碱金属碳酸叔丁酯与甲磺酰氯（可选择在相转移催化剂或芳香胺存在下）反应制备的。
• FREESTANDING ION GEL AND METHOD FOR PREPARING THE SAME
  申请人：Research & Business Foundation Sungkyunkwan University

  公开号：US20210054127A1

  公开（公告）日：2021-02-25

  Disclosed is preparation of a freestanding ion gel having high stability and high ionic conductivity based on surface-activity ionic liquids. Further, disclosed is a solid electrolyte using the ion gel. A method for preparing the freestanding ion gel include mixing a surface-activity ionic liquid having an alkyl group having 8 or greater carbon atoms, a crosslinking agent, water and oil with each other to form a bicontinuous microemulsion mixture; ii) adding an initiator to the mixture; and iii) curing the mixture using ultraviolet (UV) or thermal energy to form a freestanding ion gel.
• US5151542A
  申请人：——

  公开号：US5151542A

  公开（公告）日：1992-09-29