(E)-5-methyl-2-(prop-1-en-1-yl)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (E)-5-methyl-2-(prop-1-en-1-yl)pyridine
• 英文别名: 5-methyl-2-[(E)-prop-1-enyl]pyridine
• 化学式: C₉H₁₁N
• 分子量: 133.193
• InChiKey: JIWMISDWBJIDTJ-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-甲基吡啶 、 3-溴丙烯 在 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 1-金刚烷甲酸 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 以54%的产率得到(E)-5-methyl-2-(prop-1-en-1-yl)pyridine
  参考文献：
  名称：

  钌催化的取代吡啶衍生物的C6-丙烯基化反应：直接和直接C ？H激活

  摘要：

  一颗石头，两只鸟：在存在烯丙基溴和催化量的[{Ru（p- cymene）Cl 2 } 2 ]的情况下，芳基吡啶衍生物经历了吡啶部分的意外的直接C6-丙烯基化反应。涉及顺序和选择性的直接和定向C A一锅一催化剂三组分反应 ħ活化反应也被开发（见方案）。

  DOI：

  10.1002/chem.201202379

文献信息

• Process for preparing alkenyl-substituted heterocycles
  申请人：——

  公开号：US20020123633A1

  公开（公告）日：2002-09-05

  Described are preferred processes for preparing alkenyl-substituted nitrogenous heterocycles such as vinylpyridines, which comprise reacting a corresponding methyl-substituted heterocycle with a C 1 compound such as formadehyde in the vapor phase over a zeolite catalyst having acidic and basic catalytic sites. The preferred zeolite is a medium-pore zeolite, for example having a constraint index of about 0.5 to about 12. Processes of the invention can be conducted as facile, one-step syntheses utilizing relatively low ratios of alkyl-substituted starting heterocycle (e.g. &agr;-picoline or &ggr;-picoline) to formaldehyde while nonetheless achieving high selectivities and yields of the corresponding alkenyl compound.

  本文描述了制备烯基取代的含氮杂环化合物，如乙烯吡啶的首选方法，包括将相应的甲基取代的杂环与C1化合物（如甲醛）在具有酸性和碱性催化位点的沸石催化剂上在气相中反应。首选沸石是中孔沸石，例如具有约0.5至约12的约束指数。本发明的方法可以作为简便的一步合成进行，使用相对较低的烷基取代起始杂环（例如α-苯基吡啶或γ-苯基吡啶）与甲醛的比例，同时实现相应烯基化合物的高选择性和产率。
• HISTONE DEACETYLASE INHIBITORS
  申请人：Bressi C. Jerome

  公开号：US20070149495A1

  公开（公告）日：2007-06-28

  Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R 1 , R 2 , R 3 and R 4 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C 1-12 alkyl, C 2-12 aminoalkyl or C 2-12 oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R 3 and R 4 are not both hydrogen; R 5 is selected from the group consisting of a carbonyl, a substituted or unsubstituted C 1-3 alkyl, a substituted or unsubstituted —C 1-3 alkyl-C(O), a substituted or unsubstituted —C(O)—C 1-3 alkyl, and a substituted or unsubstituted —C(O)C(O)C 1-3 alkyl; M is a substituent capable of complexing with a protein metal ion; and L is a substituent comprising a chain of 3-12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.
• Scintillator plate for radiation and production method of the same
  申请人：Shoji Takehiko

  公开号：US20070108393A1

  公开（公告）日：2007-05-17

  A scintillator plate for radiation comprising a substrate having thereon a phosphor layer comprising CsI and two or more activators ach having a melting point different from a melting point of CsI, wherein each content of the two or more activators is 0.01 % or more based on CsI; and the scintillator plate is produced by forming the phosphor layer on the substrate via a vacum evaporation method using a source material comprising CsI and two or more activators.
• US6596872B2
  申请人：——

  公开号：US6596872B2

  公开（公告）日：2003-07-22
• US7399884B2
  申请人：——

  公开号：US7399884B2

  公开（公告）日：2008-07-15