diallyl[pentafluorophenyl(thienyl-2)methyl]amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diallyl[pentafluorophenyl(thienyl-2)methyl]amine
• 英文别名: N-[(2,3,4,5,6-pentafluorophenyl)-thiophen-2-ylmethyl]-N-prop-2-enylprop-2-en-1-amine
• 化学式: C₁₇H₁₄F₅NS
• 分子量: 359.363
• InChiKey: WIHOEOVWYCSJOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  31.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  氯三(2,3,4,5,6-五氟苯基)硅烷 以 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 16.08h， 生成 diallyl[pentafluorophenyl(thienyl-2)methyl]amine
  参考文献：
  名称：

  Synthesis of Pentafluorophenylmethylamines via Silicon Mannich Reaction

  摘要：

  The three-component coupling of aldehydes, secondary amines, and methoxytris(pentafluorophenyl)silane, MeOSi(C6F5)(3), affording pentafluorophenylmethylamines has been described. The generation of the five-coordinate silicate intermediate is believed to be the key feature responsible for the efficiency of the reaction.

  DOI：

  10.1021/ol050845l

文献信息

• Synthesis of Pentafluorophenylmethylamines via Silicon Mannich Reaction
  作者：Alexander D. Dilman、Pavel A. Belyakov、Alexander A. Korlyukov、Marina I. Struchkova、Vladimir A. Tartakovsky

  DOI：10.1021/ol050845l

  日期：2005.7.1

  The three-component coupling of aldehydes, secondary amines, and methoxytris(pentafluorophenyl)silane, MeOSi(C6F5)(3), affording pentafluorophenylmethylamines has been described. The generation of the five-coordinate silicate intermediate is believed to be the key feature responsible for the efficiency of the reaction.