methyl 4-[(E)-2-(4-fluorophenyl)ethenyl]benzoate | 159754-15-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: methyl 4-[(E)-2-(4-fluorophenyl)ethenyl]benzoate
• 英文别名: methyl (E)-4-(4-fluorostyryl)benzoate；methyl 4-((E)-4-fluorostyryl)benzoate
• CAS: 159754-15-1
• 化学式: C₁₆H₁₃FO₂
• 分子量: 256.276
• InChiKey: CPLGJPNAPALYMQ-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.78
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  methyl 4-[(E)-2-(4-fluorophenyl)ethenyl]benzoate 在 水 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 三乙胺 、 sodium hydroxide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 4-({4-[(E)-2-(4-fluorophenyl)ethenyl]benzoyl}amino)-1-methyl-N-[1-methyl-5-({[2-(4-morpholinyl)ethyl]amino}carbonyl)-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxamide
  参考文献：
  名称：

  An evaluation of Minor Groove Binders as anti- Trypanosoma brucei brucei therapeutics

  摘要：

  A series of 32, structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in the nanomolar range, and represent hits for further optimisation towards novel treatments for Human and Animal African Trypanosomiases. Moreover, SAR indicates that the head group linking moiety is a significant modulator of biological activity. (C) 2016 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.orgilicensesiby/4.0/).

  DOI：

  10.1016/j.ejmech.2016.03.064
• 作为产物：
  描述：

  1-(2,2-二溴乙烯基)-4-氟苯 在 bis(1,5-cyclooctadiene)nickel (0) 、 三乙胺 、 亚磷酸二甲酯 、 4,4'-二叔丁基-2,2'-二吡啶 、 lithium chloride 、 sodium hydroxide 、 magnesium chloride 、 锌 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 异丙醇 为溶剂， 反应 16.5h， 生成 methyl 4-[(E)-2-(4-fluorophenyl)ethenyl]benzoate
  参考文献：
  名称：

  镍卤化物与乙烯基溴的镍催化还原偶联制备乙烯基芳烃

  摘要：

  这项工作强调了在温和且易于操作的镍催化反应条件下，通过芳基卤化物与乙烯基溴的还原偶联来合成取代的乙烯基芳烃。广泛使用的芳基卤化物，包括杂芳族化合物和乙烯基溴化物，以中等至优异的收率生产了具有高官能团耐受性的产品。镍催化系统在两个C（sp 2）-卤化物偶合体之间显示出良好的化学选择性，从而证明了不同于其他逐步方案的机理途径。

  DOI：

  10.1002/anie.201607959

文献信息

• Novel 5-aminotetrahydroquinoline-2-carboxylic acids and their use
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20140031391A1

  公开（公告）日：2014-01-30

  The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.

  本申请涉及新颖的5-氨基-5,6,7,8-四氢喹啉-2-羧酸，以及它们的制备方法，它们用于治疗和/或预防疾病，以及它们用于生产用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管和心肺疾病。
• Rhodium-catalyzed oxidative decarbonylative Heck-type coupling of aromatic aldehydes with terminal alkenes
  作者：Lei Kang、Feng Zhang、Lin-Ting Ding、Luo Yang

  DOI：10.1039/c5ra21610a

  日期：——

  rhodium-catalyzed oxidative decarbonylative Heck-type coupling of aromatic aldehydes with terminal alkenes to afford 1,2-disubstituted alkenes with good regio- and E-selectivity is developed. This reaction employs readily available aromatic aldehydes as the aryl electrophile counterpart and relies on selected acyl chloride as the crucial additive to activate the rhodium catalyst precursor.

  开发了铑催化的芳族醛与末端烯烃的氧化脱羰基Heck型偶联，以提供具有良好区域和E选择性的1,2-二取代的烯烃。该反应采用容易获得的芳族醛作为芳基亲电子试剂，并依赖于选定的酰氯作为活化铑催化剂前体的关键添加剂。
• STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES
  申请人：Kung Hank F.

  公开号：US20100266500A1

  公开（公告）日：2010-10-21

  This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

  本发明涉及一种成像淀粉样沉积物的方法，以及标记化合物和制备标记化合物的方法，以便成像淀粉样沉积物。本发明还涉及化合物，以及制备化合物的方法，用于抑制淀粉样蛋白聚集形成淀粉样沉积物，并且涉及将治疗剂输送到淀粉样沉积物的方法。
• NOVEL 5-AMINOTETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS AND THEIR USE
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150148376A1

  公开（公告）日：2015-05-28

  The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.

  本申请涉及新型5-氨基-5,6,7,8-四氢喹啉-2-羧酸的制备方法、其用于治疗和/或预防疾病的用途以及用于制备治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管和心肺疾病的用途。
• 5-aminotetrahydroquinoline-2-carboxylic acids and their use
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US10053428B2

  公开（公告）日：2018-08-21

  The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.

  本申请涉及新型 5-氨基-5,6,7,8-四氢喹啉-2-羧酸、其制备工艺、其治疗和/或预防疾病的用途，以及其用于生产治疗和/或预防疾病，特别是治疗和/或预防心血管和心肺疾病的药物。