亚磷酸 | 10294-56-1

• 物质功能分类: 无机化工 - 无机盐 - 磷化物、金属的磷酸、偏磷酸、次磷酸和焦磷酸盐
• 分子结构分类: 无机化合物 - 均质非金属化合物 - 非金属氧阴离子化合物
• 中文名称: 亚磷酸
• 中文别名: 正磷酸
• 英文名称: phosphorous acid
• 英文别名: phosphorus acid；anhydrous phosphorous acid；Phosphonate (HPO32-)；Phosphorane, trihydroxy-
• CAS: 10294-56-1
• 化学式: H₃O₃P
• 分子量: 81.9958
• InChiKey: OJMIONKXNSYLSR-UHFFFAOYSA-N

物化性质

• 物理描述：
  Phosphorous acid appears as a white or yellow crystalline solid (melting point 70.1 deg C) or a solution of the solid. Density 1.651 g /cm3 . Contact may severely irritate skin, eyes, and mucous membranes. Toxic by ingestion, inhalation and skin absorption.

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xn,C
• 安全说明：
  S1/2,S26,S36/37/39,S45
• 危险类别码：
  R22,R35
• 危险品运输编号：
  UN 2834
• 海关编码：
  2811199090

SDS

Name:	Phosphorous acid 98% Material Safety Data Sheet
Synonym:	Phosphonic acid; Phosphorous acid
CAS:	10294-56-1

Section 1 - Chemical Product MSDS Name:Phosphorous acid 98% Material Safety Data Sheet
Synonym:Phosphonic acid; Phosphorous acid

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
10294-56-1	Phosphorous acid	98	237-066-7

Hazard Symbols: C
Risk Phrases: 22 35

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed. Causes severe burns.Hygroscopic (absorbs moisture from the air).Air sensitive.
Potential Health Effects
Eye:
Contact with liquid is corrosive to the eyes and causes severe burns.
Skin:
Contact with liquid is corrosive and causes severe burns and ulceration. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
Causes gastrointestinal tract burns.
Inhalation:
Irritation may lead to chemical pneumonitis and pulmonary edema.
Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. Aspiration may lead to pulmonary edema. May cause systemic effects.
Chronic:
Effects may be delayed. Repeated contact may cause corneal damage.

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Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Substance is noncombustible. Contact with metals may evolve flammable hydrogen gas.
Extinguishing Media:
For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Do NOT get water inside containers. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Cover with sand, dry lime or soda ash and place in a closed container for disposal. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Minimize dust generation and accumulation. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Use only in a chemical fume hood. Discard contaminated shoes.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from metals. Corrosives area. Do not store in metal containers.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 10294-56-1: CAS# 13598-36-2: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Chunks
Color: white
Odor: Faint characteristic odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 200 deg C @ 760 mm Hg
Freezing/Melting Point: 73 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: >180 deg C
Solubility in water: Soluble.
Specific Gravity/Density: 1.6510g/cm3
Molecular Formula: H3O3P
Molecular Weight: 82.00

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions. Hygroscopic: absorbs moisture or water from the air. Phosphorous acid, ortho reacts with air to form Phosphoric acid.
Conditions to Avoid:
Dust generation, exposure to air, excess heat.
Incompatibilities with Other Materials:
Water, metals, strong oxidizing agents, strong reducing agents, strong bases.
Hazardous Decomposition Products:
Oxides of phosphorus, phosphine.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 10294-56-1 unlisted.
CAS# 13598-36-2: SZ6400000 LD50/LC50:
Not available.
CAS# 13598-36-2: Oral, mouse: LD50 = 1700 mg/kg; Oral, rat: LD50 = 1895 mg/kg.
Carcinogenicity:
Phosphorous acid (2 legit CAS numbers) - Not listed by ACGIH, IARC, or NTP.
Phosphorous acid - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: PHOSPHOROUS ACID
Hazard Class: 8
UN Number: 2834
Packing Group: III
IMO
Shipping Name: PHOSPHOROUS ACID
Hazard Class: 8
UN Number: 2834
Packing Group: III
RID/ADR
Shipping Name: PHOSPHOROUS ACID
Hazard Class: 8
UN Number: 2834
Packing group: III

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 22 Harmful if swallowed.
R 35 Causes severe burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 10294-56-1: No information available.
CAS# 13598-36-2: 1
Canada
CAS# 10294-56-1 is listed on Canada's DSL List.
CAS# 13598-36-2 is listed on Canada's DSL List.
CAS# 10294-56-1 is not listed on Canada's Ingredient Disclosure List.
CAS# 13598-36-2 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 10294-56-1 is listed on the TSCA inventory.
CAS# 13598-36-2 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

介绍

亚磷酸是一种无机化合物，易溶于水和醇。在空气中会缓慢氧化成正磷酸。当温度达到180℃时，它分解为磷化氢和正磷酸。亚磷酸具有一定的腐蚀性，并且作为二元酸，其酸性略强于磷酸。此外，亚磷酸还表现出强烈的还原性，能够将银离子（Ag+）还原成金属银（Ag），并能将硫酸还原为二氧化硫。

性质

正磷酸是一种中等强度的无机酸，会与碱类物质发生剧烈反应。在偶氮化合物和环氧化合物的作用下，它会发生剧烈聚合。燃烧时会产生有毒的磷氧化物烟气。亚磷酸接触醇类、醛、氰化物、酮、酚、酯、硫化物或卤代有机物时会分解，并释放出有毒烟雾，同时浸蚀多种金属，生成易燃易爆气体。

应用

亚磷酸主要用于以下几个方面：作为还原剂、尼龙增白剂；制备亚磷酸盐原料和农药中间体；合成用于水处理的有机磷化合物。此外，它还被广泛应用于治疗前列腺肥大引起的排尿障碍，是一种高选择性的α1A受体阻断剂。

反应信息

• 作为反应物：
  描述：

  亚磷酸 在 硫酸 作用下， 以 水 为溶剂， 生成 磷酸
  参考文献：
  名称：

  P 3电极上的H 3 PO 3电化学行为：吸附和氧化动力学

  摘要：

  掺杂有H 3 PO 4的聚苯并咪唑型聚合物通常用作高温质子交换膜燃料电池中的质子传导相。然而，H 3 PO 4在燃料电池操作期间不稳定，并且在Pt表面上被氢还原成较低氧化态的磷化合物，例如H 3 PO 3。在这项工作中，研究了在Pt电极上H 3 PO 3氧化的动力学，包括研究H 4 P 2 O 6作为一种可能的氧化中间体。^ h 3 PO 3氢在低电位沉积区域的吸附由对应于特定Pt晶面上吸附的三重Langmuir等温线描述。氢的共吸附，以及SO 4 2-，HSO 4 -离子降低吸附H的总量3 PO 3。发现在金属Pt表面上确定的H 3 PO 3阳极氧化的表观电荷转移系数是浓度和温度依赖性的，表明阳极过程的性质是复杂的。根据H 3 PO 3和H 4 P 2 O 6的计时电位测量结论是，虽然通过与PtO x的化学反应将H 3 PO 3氧化，但H 4 P 2 O 6仍未在PtO x表面进行阳极氧

  DOI：

  10.1016/j.electacta.2016.07.045
• 作为产物：
  描述：

  磷化氢 在 氯 作用下， 生成 亚磷酸
  参考文献：
  名称：

  Parker, M. L., 1953, vol. 24, p. 81

  摘要：

  DOI：
• 作为试剂：
  描述：

  β-硝基苯乙烯 、 5-甲基-2-苯基吲哚 在 甲酸 、 亚磷酸 作用下， 生成
  参考文献：
  名称：

  一种合成2-芳基喹啉-4(1H)-酮的新方法

  摘要：

  开发了一种简单的一锅法，用于从可合成的2-(2-芳基(烷基)-3-氧代吲哚啉-2-基)-2-苯基乙腈合成2-取代的喹啉-4( 1H )-酮。

  DOI：

  10.1007/s10593-024-03333-z

文献信息

• Phosphono/biaryl substituted amino acid derivatives
  申请人：Ciba-Geigy Corporation

  公开号：US05250522A1

  公开（公告）日：1993-10-05

  The present invention relates to the N-phosphonomethyl-biaryl substituted amino acid derivatives of formula I ##STR1## wherein X represents a direct bond, C.sub.1-4 -alkylene or C.sub.2 -C.sub.4 -alkenylene; R and R' represent independently hydrogen, carbocyclic aryl, 6-tetrahydronaphthyl, 5-indanyl, .alpha.-(trichloromethyl, carboxyl, esterified carboxyl or amidated carboxyl)substituted-(lower alkyl or aryl-lower alkyl), acyloxymethyl optionally monosubstituted on methyl carbon by C.sub.1-20 -alkyl, by C.sub.5 -C.sub.7 -cycloalkyl, by aryl or by aryl-lower alkyl; R.sub.1 represents monocyclic carbocyclic or monocyclic heterocyclic aryl; COR.sub.3 represents carboxyl or carboxyl derivatized in form of a pharmaceutically acceptable ester; R.sub.2 and R.sub.4 represent hydrogen, lower alkyl, trifluoromethyl, lower alkoxy or halogen; and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; methods for preparation of said compounds and for the preparation of intermediates; and methods of treating disorders in mammals which are responsive to the inhibition of neutral endopeptidases by administration of said compounds to mammals in need of such treatment.

  本发明涉及公式I的N-磷酸甲基-联苯取代氨基酸衍生物，其中X代表直接键，C.sub.1-4-烷基或C.sub.2-C.sub.4-烯基；R和R'独立地代表氢、碳环芳基、6-四氢萘基、5-茚基、α-(三氯甲基、羧基、酯化羧基或酰胺化羧基)取代-(较低烷基或芳基-较低烷基)、酰氧甲基，可选地在甲基碳上单取代为C.sub.1-20-烷基、C.sub.5-C.sub.7-环烷基、芳基或芳基-较低烷基；R.sub.1代表单环碳环芳基或单环杂环芳基；COR.sub.3代表羧基或以药学上可接受的酯形式衍生的羧基；R.sub.2和R.sub.4代表氢、较低烷基、三氟甲基、较低烷氧基或卤素；以及其药学上可接受的盐；包括所述化合物的药物组合物；制备所述化合物和中间体的方法；以及通过将所述化合物用于需要此类治疗的哺乳动物来抑制中性内肽酶以治疗哺乳动物的疾病的方法。
• Phosphono substituted tetrazole derivatives as ECE inhibitors
  申请人：Ciba-Geigy Corporation

  公开号：US05550119A1

  公开（公告）日：1996-08-27

  The present invention relates to the N-phosphonomethyl substituted compounds of formula ##STR1##

  本发明涉及公式##STR1##的N-磷酸甲基取代化合物。
• Tetraisoquinoline compounds which have useful pharmaceutical utility
  申请人：The Boots Company PLC

  公开号：US05519034A1

  公开（公告）日：1996-05-21

  Tetrahydroisoquinoline compounds of formula I ##STR1## and pharmaceutically acceptable salts and lipophilic ester thereof have utility as analgesics and in the treatment of psychoses, Parinson's disease, Lesch-Nyan syndrome, attention deficit disorder or cognitive impairment or in the relief of drug dependence or tardive dyskinesia.

  四氢异喹啉化合物的化学式为I ##STR1##，其药用盐和亲脂性酯具有镇痛作用，并可用于治疗精神病、帕金森病、莱施-尼恩综合征、注意力缺陷障碍或认知障碍，以及缓解药物依赖或迟发性运动障碍。
• Degradation of tri(2-chloroisopropyl) phosphate by the UV/H2O2 system: Kinetics, mechanisms and toxicity evaluation
  作者：Huan He、Qiuyi Ji、Zhanqi Gao、Shaogui Yang、Cheng Sun、Shiyin Li、Limin Zhang

  DOI：10.1016/j.chemosphere.2019.124388

  日期：2019.12

  into a series of hydroxylated and dechlorinated products. Based on the luminescent bacteria experimental data, the toxicity of TCPP products increased obviously as the reaction proceeded. In conclusion, degradation of high concentration TCPP in UV/H2O2 systems may result in more toxic substances, but its potential application for real wastewater is promising in the future after appropriate optimization

  开发了一种基于紫外线辐射与 H2O2 (UV/ ) 联合降解磷酸三氯异丙基酯 (TCPP) 的光降解技术。在超纯水中，观察到伪一级反应，使用 250 W 紫外光照射和 50 mg L-1 ，5 mg L-1 TCPP 的降解速率常数达到 0.0035 min-1 (R2 = 0.9871)。具体而言，Cl-和PO43-的产率分别达到0.19 mg L-1和0.58 mg L-1。总有机碳（TOC）去除率为43.02%。反应后TCPP溶液的pH值为3.46。质谱检测数据显示 TCPP 部分转化为一系列羟基化和脱氯产物。根据发光细菌实验数据，随着反应的进行，TCPP产物的毒性明显增加。
• Catalytic Phosphite Hydrolysis under Neutral Reaction Conditions
  作者：Werner Oberhauser、Gabriele Manca

  DOI：10.1021/acs.inorgchem.8b00546

  日期：2018.5.7

  Cationic phosphametallocene-based platinum(II) aqua complexes were used as efficient precatalysts for the hydrolysis of aromatic and aliphatic tertiary phosphites under neutral reaction conditions at room temperature, leading to the selective cleavage of one P–O bond of the phosphite. NMR labeling experiments combined with stoichiometric model reactions and theoretical density functional theory calculations

  阳离子磷酸金属茂基铂（II）水络合物被用作在室温下在中性反应条件下水解芳族和脂族叔亚磷酸酯的有效预催化剂，从而导致亚磷酸酯的一个P–O键的选择性裂解。使用适当的模型化合物进行的NMR标记实验与化学计量模型反应和理论密度泛函理论计算相结合，阐明了有效的催化循环，该循环包括分子内水分子转移至顺式配位的亚磷酸酯分子。