biphenyl nitrite

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: biphenyl nitrite
• 英文别名: 1,1'-Biphenyl;nitrous acid；1,1'-biphenyl;nitrous acid
• 化学式: C₁₂H₁₀*HNO₂
• 分子量: 201.225
• InChiKey: JSBIZEQOBQNSNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  biphenyl nitrite 、 甲酰氯 在 Ki 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 4'-(2-Cyclopropyl-2-oxoethoxy)[1,1'-biphenyl]-2-carbonitrile
  参考文献：
  名称：

  Biphenyl-substituted quinoline derivatives

  摘要：

  式为##STR1##的化合物，其中X，R.sub.1，R.sub.2，R.sub.3，R.sub.4，R.sub.5，R.sub.6，A，B，D和E的定义如本文所述。这些化合物抑制肾素-血管紧张素系统的作用，因此例如作为降压药物是有用的。

  公开号：

  US06117885A1

文献信息

• Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity
  申请人：UNIVERSITY OF MARYLAND, BALTIMORE

  公开号：US10617685B2

  公开（公告）日：2020-04-14

  Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including prostate cancer, castration resistant prostate cancer, bladder cancer, pancreatic cancer, hepatocellular carcinoma, benign prostatic hyperplasia (BPH), Kennedy's disease, androgenetic alopecia, breast cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy.

  非类固醇和类固醇化合物可导致雄激素受体（AR）（包括全长和剪接变体）的下调，诱导凋亡并抑制对雄激素敏感的癌细胞的增殖和迁移。类固醇化合物和非类固醇化合物可作为预防和/或治疗癌症的药物，包括前列腺癌、阉割抗性前列腺癌、膀胱癌、胰腺癌、肝细胞癌、良性前列腺增生症（BPH）、肯尼迪病、雄激素性脱发、乳腺癌、雄激素不敏感综合征以及脊柱和球部肌肉萎缩症。
• NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY
  申请人：UNIVERSITY OF MARYLAND, BALTIMORE

  公开号：US20170266181A1

  公开（公告）日：2017-09-21

  Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including prostate cancer, castration resistant prostate cancer, bladder cancer, pancreatic cancer, hepatocellular carcinoma, benign prostatic hyperplasia (BPH), Kennedy's disease, androgenetic alopecia, breast cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy.
• US6117885A
  申请人：——

  公开号：US6117885A

  公开（公告）日：2000-09-12
• Biphenyl-substituted quinoline derivatives
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US06117885A1

  公开（公告）日：2000-09-12

  Compounds of the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, A, B, D and E are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.

  式为##STR1##的化合物，其中X，R.sub.1，R.sub.2，R.sub.3，R.sub.4，R.sub.5，R.sub.6，A，B，D和E的定义如本文所述。这些化合物抑制肾素-血管紧张素系统的作用，因此例如作为降压药物是有用的。