(4-hydroxyphenyl)-(4-methoxy-3-methylphenyl)-methanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-hydroxyphenyl)-(4-methoxy-3-methylphenyl)-methanone
• 英文别名: (4-Hydroxyphenyl)-(4-methoxy-3-methylphenyl)methanone
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: WHNRDUQISDYGJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基苯甲醚 、 对羟基苯甲酸 在 indium(III) chloride 、 二甲基一氯硅烷 作用下， 以 1,2-二氯乙烷 为溶剂， 以62%的产率得到(4-hydroxyphenyl)-(4-methoxy-3-methylphenyl)-methanone
  参考文献：
  名称：

  In(III)-Mediated Chemoselective Dehydrogenative Interaction of ClMe₂SiH with Carboxylic Acids:  Direct Chemo- and Regioselective Friedel−Crafts Acylation of Aromatic Ethers

  摘要：

  Chemoselective dehydrogenative interaction of ClMe2SiH with a carboxylic acid group in the presence of InX3 is reported. C-13 NMR investigation revealed the formation of PhCOOSi(Cl)Me-2 as the major transient intermediate. Chemo- and regioselective Friedel-Crafts acylation of aromatic ethers directly from carboxylic acids was established.

  DOI：

  10.1021/ol062723e

文献信息

• Non-steroidal modulators of estrogen receptors
  申请人：——

  公开号：US20020161007A1

  公开（公告）日：2002-10-31

  Estrogen receptor modulators, compositions comprising the compounds and methods relating to the use thereof are described. The compounds may be used in inhibiting the proliferation of and/or induces apoptosis in human breast cancer cells.

  本文描述了雌激素受体调节剂，包括该化合物的组合物和使用方法。该化合物可用于抑制人乳腺癌细胞的增殖和/或诱导凋亡。
• [EN] NON-STEROIDAL MODULATORS OF ESTROGEN RECEPTORS<br/>[FR] MODULATEURS NON STEROIDIENS DE RECEPTEURS DES OESTROGENES
  申请人：TRINITY COLLEGE DUBLIN

  公开号：WO2002066415A2

  公开（公告）日：2002-08-29

  Estrogen receptor modulators, compositions comprising the compounds and methods relating to the use thereof are described. The compounds may be used in inhibiting the proliferation of and/or induces apoptosis in human breast cancer cells.
• In(III)-Mediated Chemoselective Dehydrogenative Interaction of ClMe₂SiH with Carboxylic Acids:  Direct Chemo- and Regioselective Friedel−Crafts Acylation of Aromatic Ethers
  作者：Srinivasarao Arulananda Babu、Makoto Yasuda、Akio Baba

  DOI：10.1021/ol062723e

  日期：2007.2.1

  Chemoselective dehydrogenative interaction of ClMe2SiH with a carboxylic acid group in the presence of InX3 is reported. C-13 NMR investigation revealed the formation of PhCOOSi(Cl)Me-2 as the major transient intermediate. Chemo- and regioselective Friedel-Crafts acylation of aromatic ethers directly from carboxylic acids was established.