1-(2-methyl-4-nitrophenyl)thiourea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-methyl-4-nitrophenyl)thiourea
• 英文别名: (2-methyl-4-nitro-phenyl)-thiourea；(2-Methyl-4-nitro-phenyl)-thioharnstoff；(2-Methyl-4-nitrophenyl)thiourea
• 化学式: C₈H₉N₃O₂S
• mdl: MFCD03305708
• 分子量: 211.244
• InChiKey: RRSNRUQPEWBJAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-硝基-2-甲苯胺 在 乙醇 、 氨 、 水 作用下， 生成 1-(2-methyl-4-nitrophenyl)thiourea
  参考文献：
  名称：

  Dyson; George, Journal of the Chemical Society, 1924, vol. 125, p. 1704

  摘要：

  DOI：

文献信息

• Green and efficient synthesis of thioureas, ureas, primary <i>O</i>-thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea
  作者：Nastaran Bagherzadeh、Ali Reza Sardarian、Iman Dindarloo Inaloo

  DOI：10.1039/d1nj01827b

  日期：——

  developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(II) chloride [ChCl][SnCl2]2 with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can

  通过使用硫脲/尿素作为生物相容性硫代羰基（羰基）源，开发了一种有效且通用的催化方法，用于直接制备各种伯O-硫代氨基甲酸酯/氨基甲酸酯以及单取代硫脲/脲。该过程使用氯化胆碱/氯化锡 ( II ) [ChCl][SnCl 2 ] 2，具有作为绿色催化剂和反应介质的双重作用，以中等至极好的收率提供所需产物。此外，DES 可以很容易地回收和重复使用七个循环，而其活性没有显着损失。此外，该方法在大规模合成所需产物方面表现出非常好的性能。
• Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
  申请人：Sekiguchi Yoshinori

  公开号：US20050197350A1

  公开（公告）日：2005-09-08

  The present invention relates to novel compounds of the Formula (I): which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

  本发明涉及一种新的化合物，其化学式为(I)，该化合物作为MCH受体拮抗剂。这些组合物在制药组合物中的应用包括预防或治疗改善记忆功能、睡眠和觉醒、焦虑、抑郁、情绪障碍、癫痫、肥胖症、糖尿病、食欲和进食障碍、心血管疾病、高血压、血脂异常、心肌梗死、暴食症包括贪食症、厌食症、精神障碍包括躁郁症、精神分裂症、谵妄、痴呆、压力、认知障碍、注意力缺陷障碍、物质滥用障碍和运动障碍包括帕金森病、癫痫和成瘾等。
• Novel quinazoline derivatives and methods of treatment related to the use thereof
  申请人：Sekiguchi Yoshinori

  公开号：US20070010671A1

  公开（公告）日：2007-01-11

  The present invention relates to novel compounds of Formula (1): which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

  本发明涉及一种新的化合物，其化学式为(1)，并作为MCH受体拮抗剂。这些化合物在制药组合物中的使用包括预防或治疗改善记忆功能、睡眠和觉醒、焦虑、抑郁、情绪障碍、癫痫、肥胖症、糖尿病、食欲和进食障碍、心血管疾病、高血压、血脂异常、心肌梗塞、暴食障碍（包括贪食症、厌食症）、精神障碍（包括躁郁症、精神分裂症、谵妄、痴呆）、压力、认知障碍、注意力缺陷障碍、物质滥用障碍和运动障碍（包括帕金森病、癫痫和成瘾）。
• Dyson; George, Journal of the Chemical Society, 1924, vol. 125, p. 1704
  作者：Dyson、George

  DOI：——

  日期：——