o-(N-benzylamino)benzyldimethylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-(N-benzylamino)benzyldimethylamine
• 英文别名: N-benzyl-2-[(dimethylamino)methyl]aniline
• 化学式: C₁₆H₂₀N₂
• 分子量: 240.348
• InChiKey: GXSSGNNAMXLIAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  o-(N-benzylamino)benzyldimethylamine 在 二丁基镁 作用下， 以 乙醚 、 正庚烷 为溶剂， 反应 18.0h， 以81%的产率得到
  参考文献：
  名称：

  由胺-酰胺杂化配体螯合的锂、镁和锌中心 N,N'-螯合

  摘要：

  锂、镁和锌配合物N , N '-螯合胺-酰胺杂化配体 ([2-(Me 2 NCH 2 )C 6 H 4 NR] - , 缩写为 L N R ) 的合成及结构, 其中报道了 R = H、SiMe 3或 Bn)。空间要求最低的 L N H 与各种镁源的反应通过从 L N HMg n Bu ( 2 )中消除正丁烷或通过 L N 的反应得到六聚酰亚胺 [L N Mg] 6 ( 4 )HLi ( 1 ) 与 MeMgBr。[L N H] 2 Mg ( 3 ) 通过将 0.5 equiv 的n Bu 2 Mg 或 Mg[N(SiMe 3 ) 2 ] 2添加到 L N H 2中并与 1 equiv 的n Bu 2 Mg 反应得到2 . L N HMgN(SiMe 3 ) 2 ( 6 ) 和同构的 L N HZnN(SiMe 3 ) 2 ( 16) 已使用两种不同的方法制备：通过 Zn/Mg[N(SiMe

  DOI：

  10.1021/acs.inorgchem.1c03850
• 作为产物：
  描述：

  2-二甲氨基甲基苯胺 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 60.0h， 生成 o-(N-benzylamino)benzyldimethylamine
  参考文献：
  名称：

  Aluminium complexes containing N,N′-chelating amino-amide hybrid ligands applicable for preparation of biodegradable polymers

  摘要：

  Five aluminium complexes containing N,N'-chelating ligands ([2-(Me2NCH2)C6H4N(R)](-); R = H, SiMe3 or benzyl (Bn)) were prepared and structurally characterized by NMR and crystallographic techniques. Aluminium atoms in all compounds are pseudotetrahedrally coordinated with extremely short intramolecular interaction of the pendant amino group (d(Al-N) = 1.96-2.00 angstrom). The catalytic performance of selected complexes (similar to 0.1-0.2 mol. %), either with or without an external co-initiator, in ring opening (co) polymerization of epsilon-caprolactone, L-lactide and trimethylene carbonate was tested yielding satisfactory to excellent amount of polymeric material with M-n similar to 15-70 kg/mol for e-caprolactone, and similar to 30 kg/mol for trimethylene carbonate with good degree of control over the molar mass distribution, initiation efficiency. An excellent conversion of L-lactide to methyl (S,S)-O-lactyllactate is observed upon catalysis by one of the complexes at room temperature. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2014.12.010

文献信息

• Ito, Yoshihiko; Nakajo, Eiji; Saegusa, Takeo, Synthetic Communications, 1986, vol. 16, # 9, p. 1073 - 1080
  作者：Ito, Yoshihiko、Nakajo, Eiji、Saegusa, Takeo

  DOI：——

  日期：——
• ITO YOSHIHIKO; NAKAJO EIJI; SAEGUSA TAKEO, SYNTH. COMMUN., 16,(1986) N 9, 1073-1080
  作者：ITO YOSHIHIKO、 NAKAJO EIJI、 SAEGUSA TAKEO

  DOI：——

  日期：——
• Aluminium complexes containing N,N′-chelating amino-amide hybrid ligands applicable for preparation of biodegradable polymers
  作者：Hana Kampová、Emílie Riemlová、Jitka Klikarová、Vladimír Pejchal、Jan Merna、Petr Vlasák、Petr Švec、Zdeňka Růžičková、Aleš Růžička

  DOI：10.1016/j.jorganchem.2014.12.010

  日期：2015.2

  Five aluminium complexes containing N,N'-chelating ligands ([2-(Me2NCH2)C6H4N(R)](-); R = H, SiMe3 or benzyl (Bn)) were prepared and structurally characterized by NMR and crystallographic techniques. Aluminium atoms in all compounds are pseudotetrahedrally coordinated with extremely short intramolecular interaction of the pendant amino group (d(Al-N) = 1.96-2.00 angstrom). The catalytic performance of selected complexes (similar to 0.1-0.2 mol. %), either with or without an external co-initiator, in ring opening (co) polymerization of epsilon-caprolactone, L-lactide and trimethylene carbonate was tested yielding satisfactory to excellent amount of polymeric material with M-n similar to 15-70 kg/mol for e-caprolactone, and similar to 30 kg/mol for trimethylene carbonate with good degree of control over the molar mass distribution, initiation efficiency. An excellent conversion of L-lactide to methyl (S,S)-O-lactyllactate is observed upon catalysis by one of the complexes at room temperature. (C) 2014 Elsevier B.V. All rights reserved.
• Lithium, Magnesium, and Zinc Centers N,N′-Chelated by an Amine–Amide Hybrid Ligand
  作者：Tomáš Chlupatý、Zdeňka Růžičková、Hana Kampová、Jan Merna、Aleš Růžička

  DOI：10.1021/acs.inorgchem.1c03850

  日期：2022.6.27

  reactions of 2 or 3 with 1 provide the heterotrimetallic complex [LNH]4Li2Mg (5). Benzyl- or trimethylsilyl-substituted anilines [LN(SiMe3)H (7) and LN(Bn)H (8)] with 0.5 equiv of nBu2Mg allow the formation of homoleptic bis(amides) of the [LN(R)]2Mg type (10 and 11). Nevertheless, only the silylated secondary amine 7 is able to provide the heteroleptic n-butylmagnesium amide LN(SiMe3)MgnBu (9) upon reaction

  锂、镁和锌配合物N , N '-螯合胺-酰胺杂化配体 ([2-(Me 2 NCH 2 )C 6 H 4 NR] - , 缩写为 L N R ) 的合成及结构, 其中报道了 R = H、SiMe 3或 Bn)。空间要求最低的 L N H 与各种镁源的反应通过从 L N HMg n Bu ( 2 )中消除正丁烷或通过 L N 的反应得到六聚酰亚胺 [L N Mg] 6 ( 4 )HLi ( 1 ) 与 MeMgBr。[L N H] 2 Mg ( 3 ) 通过将 0.5 equiv 的n Bu 2 Mg 或 Mg[N(SiMe 3 ) 2 ] 2添加到 L N H 2中并与 1 equiv 的n Bu 2 Mg 反应得到2 . L N HMgN(SiMe 3 ) 2 ( 6 ) 和同构的 L N HZnN(SiMe 3 ) 2 ( 16) 已使用两种不同的方法制备：通过 Zn/Mg[N(SiMe