伐哌前列素 | 85505-64-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 伐哌前列素
• 英文名称: vapiprost
• 英文别名: GR32191；GR-32191B；[1R-[1α(Z),2β,3β,5α]]-(+)-7-[5-[[(1,1'-biphenyl)-4-yl]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid；(Z)-7-[(1R,2R,3S,5S)-3-hydroxy-5-[(4-phenylphenyl)methoxy]-2-piperidin-1-ylcyclopentyl]hept-4-enoic acid
• CAS: 85505-64-2
• 化学式: C₃₀H₃₉NO₄
• 分子量: 477.644
• InChiKey: GQGRDYWMOPRROR-XUSMOFMBSA-N

物化性质

• 熔点：
  127-128 °C
• 沸点：
  649.3±55.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)
• 溶解度：
  H2O: 16 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• WGK Germany：
  3
• 安全说明：
  S22,S24/25

文献信息

• Biodegradable ocular implants and methods for treating ocular conditions
  申请人：Burkstrand J. Michael

  公开号：US20080089923A1

  公开（公告）日：2008-04-17

  Biodegradable ocular implants are described. The ocular implants include a bioactive agent that can be released within the eye to treat an ocular condition or indication. The implants can be used for the administration of a bioactive agent over prolonged periods of time. In some aspects the implants are formed of a matrix of natural biodegradable polysaccharides.

  可降解眼部植入物被描述。这些眼部植入物包括可以在眼内释放的生物活性剂，用于治疗眼部疾病或症状。这些植入物可用于在较长时间内给药生物活性剂。在某些方面，这些植入物由天然可降解多糖的基质形成。
• [EN] REDUCTION SENSITIVE BIODEGRADABLE POLYESTERAMIDES<br/>[FR] RÉDUCTION DE POLYESTERAMIDES BIODÉGRADABLES SENSIBLES
  申请人：DSM IP ASSETS BV

  公开号：WO2016020545A1

  公开（公告）日：2016-02-11

  The present invention relates to biodegradable polyesteramides (PEAs) comprising hydrophobic alpha -amino acids, diols, aliphatic dicarboxylic acids and optionally diamines whereby at least one of the dicarboxylic acids, diols or diamines comprises disulphide linkages. The present invention also relates to the use of the polyesteramides in medical applications such as cancer treatment, ophthalmic applications, therapeutic cardiovascular applications, veterinary applications, pain management applications, MSK applications and vaccine delivery compositions. The present invention also relates to a drug delivery composition comprising the PEA's and to a drug delivery system such as micro-or nanoparticles, micelles, liposomes, polymerosomes, micro- and nanogels, polymerosomes or nanotubes.

  本发明涉及包含疏水性α-氨基酸、二元醇、脂肪族二羧酸和可选二胺的可生物降解聚酯酰胺（PEAs），其中至少一种二羧酸、二元醇或二胺包含二硫键。本发明还涉及将聚酯酰胺用于医学应用，如癌症治疗、眼科应用、治疗性心血管应用、兽医应用、疼痛管理应用、MSK应用和疫苗输送组合物。本发明还涉及包含PEA的药物输送组合物以及药物输送系统，如微粒或纳米粒子、胶束、脂质体、聚合体体、微米和纳米凝胶、聚合体体或纳米管。
• Bioabsorbable, biobeneficial, tyrosine-based polymers for use in drug eluting stent coatings
  申请人：Pacetti Dirk Stephen

  公开号：US20060115449A1

  公开（公告）日：2006-06-01

  This document discloses a family of tyrosine carbonate polymers and polymer mixtures that may contain bioactive or biobeneficial polymers or constituents. Methods of making these polymers and mixtures are disclosed, as well. Also, implantable or partially implantable medical devies constructed with or from these polymers are disclosed.

  这份文件披露了一类酪氨酸碳酸酯聚合物和聚合物混合物，可能包含生物活性或生物有益的聚合物或成分。同时也披露了制备这些聚合物和混合物的方法。此外，还披露了使用这些聚合物构建的可植入或部分可植入的医疗设备。
• Coatings including natural biodegradable polysaccharides and uses thereof
  申请人：Chudzik J. Stephen

  公开号：US20070065481A1

  公开（公告）日：2007-03-22

  Biodegradable coatings and articles that include natural biodegradable polysaccharides are described. The coatings and articles are formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.

  描述了包括天然可生物降解多糖的可生物降解涂层和制品。这些涂层和制品由具有侧链偶联基团的多种天然可生物降解多糖形成。
• Latent stabilization of bioactive agents releasable from implantable medical articles
  申请人：Burkstrand Michael J.

  公开号：US20080154241A1

  公开（公告）日：2008-06-26

  Implantable medical articles comprising natural biodegradable polysaccharides are described. The polysaccharides can provide desirable release properties, and can also be degraded into products that can act as an excipient in the presence of the bioactive agent. In some aspects, the articles are ocular implants formed of a matrix of natural biodegradable polysaccharides. These ocular implants include a bioactive agent that can be released within the eye to treat an ocular condition or indication.

  描述了包含天然可生物降解多糖的可植入医疗器械。这些多糖可以提供理想的释放特性，并且在生物活性剂存在的情况下也可以降解为可作为赋形剂的产物。在某些方面，这些器械是由天然可生物降解多糖构成的眼部植入物。这些眼部植入物包括可以在眼内释放的生物活性剂，用于治疗眼部疾病或症状。