3,5,3',5'-tetramethyl-biphenyl-2,2'-diyldiamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5,3',5'-tetramethyl-biphenyl-2,2'-diyldiamine
• 英文别名: 3,5,3',5'-Tetramethyl-biphenyl-2,2'-diyldiamin；2.2'-Diamino-3.5.3'.5'-tetramethyl-diphenyl；2-(2-Amino-3,5-dimethylphenyl)-4,6-dimethylaniline；2-(2-amino-3,5-dimethylphenyl)-4,6-dimethylaniline
• 化学式: C₁₆H₂₀N₂
• 分子量: 240.348
• InChiKey: UDOTZHZDPUDQEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,5,3',5'-tetramethyl-biphenyl-2,2'-diyldiamine 生成 1,3,6,8-四甲基-9H-咔唑
  参考文献：
  名称：

  Kerschbaum, Chemische Berichte, 1895, vol. 28, p. 2800

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 水 、 一氯化碘 作用下， 生成 3,5,3',5'-tetramethyl-biphenyl-2,2'-diyldiamine
  参考文献：
  名称：

  Kerschbaum, Chemische Berichte, 1895, vol. 28, p. 2800

  摘要：

  DOI：

文献信息

• [EN] METHODS AND COMPOSITIONS FOR ENHANCING IMMUNOGENICITY OF VACCINE<br/>[FR] MÉTHODES ET COMPOSITIONS PERMETTANT D'AMÉLIORER L'IMMUNOGÉNICITÉ D'UN VACCIN
  申请人：ZHANG KANG

  公开号：WO2021217109A1

  公开（公告）日：2021-10-28

  The present invention provides compositions and methods that enhance an immune response of a treated subject to a vaccinating compositions. The composition of the present invention includes a toll-like receptor 7 agonist and/or toll-like receptor 9 agonist. Enhanced immune responses include: (1) improved antibody titer relative to that produced by administration of the vaccine in the absence of application of the composition, and (2) generation of an effective immune response to species, which is not present in the vaccinating composition or unique proteins is not present in the vaccinating composition. The compositions of the present invention may be used in conjunction with a recombinant vaccine comprising receptor binding domain (RBD) of SARS-CoV-2 generated by insect cells using baculovirus expression vector.
• [EN] POLYPEPTIDES, VACCINE COMPOSITIONS, AND USE THEREOF FOR INDUCING IMMUNE RESPONSE TO SARS-COV-2 IN PRIMATES<br/>[FR] POLYPEPTIDES, COMPOSITIONS DE VACCIN ET LEUR UTILISATION POUR INDUIRE UNE RÉPONSE IMMUNITAIRE AU SARS-COV-2 CHEZ LES PRIMATES
  申请人：ZHANG KANG

  公开号：WO2022006565A1

  公开（公告）日：2022-01-06

  Disclosed herein, in some embodiments, are methods and compositions for inducing an immune response against SARS-CoV -2 in a primate in need thereof with a recombinant polypeptide, wherein the at least a portion of the recombinant polypeptide corresponds to an amino acid residue sequence within the Receptor Binding Domain (RBD) of SARS-CoV-2 spike protein capable of forming a binding interface that interacts with a viral receptor of the primate.
• [EN] POLYPEPTIDES, VACCINE COMPOSITIONS, AND USE THEREOF FOR INDUCING IMMUNE RESPONSE TO SARS-COV-2 IN PRIMATES<br/>[FR] POLYPEPTIDES, COMPOSITIONS VACCINALES ET LEUR UTILISATION POUR INDUIRE UNE RÉPONSE IMMUNITAIRE AU SARS-COV-2 CHEZ LES PRIMATES
  申请人：[en]ZHANG, Kang

  公开号：WO2022133361A2

  公开（公告）日：2022-06-23

  Disclosed herein are methods and compositions for inducing an immune response against SARS-CoV-2 in a primate with a recombinant polypeptide, wherein the at least a portion of the recombinant polypeptide corresponds to an amino acid residue within the Receptor Binding Domain (RBD) of SARS-CoV-2 spike protein capable of forming a binding interface that interacts with a viral receptor of the primate. In some examples, the methods or compositions include an immunologic adjuvant such as TLR agonist or a SARS-CoV-2 Nucleocapsid (N) protein.