N¹,N³-bis(4-(tert-butyl)phenyl)-4-methoxyisophthalamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹,N³-bis(4-(tert-butyl)phenyl)-4-methoxyisophthalamide
• 英文别名: 1-N,3-N-bis(4-tert-butylphenyl)-4-methoxybenzene-1,3-dicarboxamide
• 化学式: C₂₉H₃₄N₂O₃
• 分子量: 458.601
• InChiKey: NIUGCPRXJUUCOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-叔丁基苯胺 、 4-甲氧基异PHTHALOYL 二氯化物 在 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 34.0h， 以55.43%的产率得到N¹,N³-bis(4-(tert-butyl)phenyl)-4-methoxyisophthalamide
  参考文献：
  名称：

  Synthesis and in vitro activities on anti-platelet aggregation of 4-methoxyisophthalamides

  摘要：

  A series of 4-methoxyisophthalamides (1d-1w) were designed and synthesized and their chemical structures were confirmed by IR, MS, H-1-NMR, and C-13-NMR. The in vitro on anti-platelet aggregation activities of these compounds were assessed by using Born method. Compounds with higher activities were selected to continue research via Cell Counting Kit-8 (CCK-8) assays of their cytotoxicities. Biological screening results revealed four compounds 1h, 1i, 1q, and 1v exhibited higher activities than the control drugs on against the platelet aggregation induced by adenosine triphosphate (ADP). Moreover, compounds 1p and 1q exhibited higher in vitro activities than picotamide induced by collagen at the concentration of 1.3 mu M. Compound 1p also possessed anti-platelet aggregation activity superior to the control drug picotamide induced by arachidonic acid (AA) at the concentration of 1.3 mu M. At the same time, the result of cytotoxicities exhibited that none of the compounds have significant cytotoxicities. Therefore, 4-methoxyisophthalamides are potential to become novel anti-platelet drugs with high activities and minimum toxicities.

  DOI：

  10.1007/s00044-018-2207-8

文献信息

• Synthesis and in vitro activities on anti-platelet aggregation of 4-methoxyisophthalamides
  作者：Xiujie Liu、Yan Wang、Lili Liu、Guangling Chen

  DOI：10.1007/s00044-018-2207-8

  日期：2018.8

  A series of 4-methoxyisophthalamides (1d-1w) were designed and synthesized and their chemical structures were confirmed by IR, MS, H-1-NMR, and C-13-NMR. The in vitro on anti-platelet aggregation activities of these compounds were assessed by using Born method. Compounds with higher activities were selected to continue research via Cell Counting Kit-8 (CCK-8) assays of their cytotoxicities. Biological screening results revealed four compounds 1h, 1i, 1q, and 1v exhibited higher activities than the control drugs on against the platelet aggregation induced by adenosine triphosphate (ADP). Moreover, compounds 1p and 1q exhibited higher in vitro activities than picotamide induced by collagen at the concentration of 1.3 mu M. Compound 1p also possessed anti-platelet aggregation activity superior to the control drug picotamide induced by arachidonic acid (AA) at the concentration of 1.3 mu M. At the same time, the result of cytotoxicities exhibited that none of the compounds have significant cytotoxicities. Therefore, 4-methoxyisophthalamides are potential to become novel anti-platelet drugs with high activities and minimum toxicities.