1-((pyridin-2'-yl)methylamino)-hexan-2-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-((pyridin-2'-yl)methylamino)-hexan-2-ol
• 英文别名: 1-(Pyridin-2-ylmethylamino)hexan-2-ol
• 化学式: C₁₂H₂₀N₂O
• 分子量: 208.304
• InChiKey: NWNHQEZQUDTFMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丁基环氧乙烷 、 2-氨甲基吡啶 在 aluminium(III) triflate 作用下， 反应 0.5h， 以87%的产率得到1-((pyridin-2'-yl)methylamino)-hexan-2-ol
  参考文献：
  名称：

  Solvent-Free Al(OTf)₃-Catalyzed Aminolysis of 1,2-Epoxides by 2-Picolylamine:  A Key Step in the Synthesis of Ionic Liquids

  摘要：

  beta-Amino alcohols N-2'-pyridylmethyl substituted 3 have been prepared in excellent yields under mild conditions by the first Lewis acid-catalyzed aminolysis of 1,2-epoxides 1 with the bihaptic amine 2-picolylamine (2) with use of 5 mol % of Al(OTf)3 under solvent-free conditions. As a representative of a new class of ionic liquids, cis-5[(4'-methylphenyl)sulfonyl]-1,2,3,4,4a,5,6,11a-octahydropyrido[1,2-alpha]quinoxalin-11-ium methanesulfonate (6) and its chloride derivative 7 have been synthesized under environmentally friendly conditions by the one-pot aminolysis of cyclohexene oxide (1a) with 2 and intramolecular cyclization of the resulting 2-[(pyridin-2'-yl)methylamino]cyclohexanol (3a).

  DOI：

  10.1021/jo049335f

文献信息

• Solvent-Free Al(OTf)₃-Catalyzed Aminolysis of 1,2-Epoxides by 2-Picolylamine:  A Key Step in the Synthesis of Ionic Liquids
  作者：Francesco Fringuelli、Ferdinando Pizzo、Simone Tortoioli、Luigi Vaccaro

  DOI：10.1021/jo049335f

  日期：2004.10.1

  beta-Amino alcohols N-2'-pyridylmethyl substituted 3 have been prepared in excellent yields under mild conditions by the first Lewis acid-catalyzed aminolysis of 1,2-epoxides 1 with the bihaptic amine 2-picolylamine (2) with use of 5 mol % of Al(OTf)3 under solvent-free conditions. As a representative of a new class of ionic liquids, cis-5[(4'-methylphenyl)sulfonyl]-1,2,3,4,4a,5,6,11a-octahydropyrido[1,2-alpha]quinoxalin-11-ium methanesulfonate (6) and its chloride derivative 7 have been synthesized under environmentally friendly conditions by the one-pot aminolysis of cyclohexene oxide (1a) with 2 and intramolecular cyclization of the resulting 2-[(pyridin-2'-yl)methylamino]cyclohexanol (3a).