1,2,4-trichloro-5-isopropyl-benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2,4-trichloro-5-isopropyl-benzene
• 英文别名: 1,2,4-Trichlor-5-isopropyl-benzol；2,4,5-Trichlor-cumol；2.4.5-Trichlor-cumol；1,2,4-Trichloro-5-propan-2-ylbenzene
• 化学式: C₉H₉Cl₃
• 分子量: 223.529
• InChiKey: WGZXXFKYUSGBND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  异丙苯 在 四氯化碳 、 碘 、 氯 作用下， 生成 1,2,4-trichloro-5-isopropyl-benzene
  参考文献：
  名称：

  Qvist, Acta Academiae Aboensis, Series B: Mathematica et Physica, 1934, vol. 8, # 4, p. 3,25

  摘要：

  DOI：

文献信息

• USE OF SUBSTITUTED 2-AMIDOBENZIMIDAZOLES, 2-AMIDOBENZOXAZOLES AND 2-AMIDOBENZOTHIAZOLES OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS
  申请人：BAYER CROPSCIENCE AG

  公开号：US20150216168A1

  公开（公告）日：2015-08-06

  The use of substituted 2-amidobenzimidazoles, 2-amidobenzoxazoles and 2-amidobenzothiazoles of the general formula (I) or salts thereof where the radicals in the general formula (I) correspond to the definitions given in the description, for enhancing stress tolerance in plants to abiotic stress, for strengthening plant growth and/or for increasing plant yield, and to selected processes for preparing the compounds mentioned above.

  使用通式(I)中的取代2-酰胺苯并咪唑、2-酰胺苯并噁唑和2-酰胺苯并噻唑或其盐，其中通式(I)中的基团与描述中给出的定义相对应，用于增强植物对非生物胁迫的耐受性，加强植物生长和/或增加植物产量，并选择性地用于制备上述化合物的过程。
• USE OF SUBSTITUTED BENZODIAZEPINONES AND BENZAZEPINONES OR THE SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS
  申请人：BAYER CROPSCIENCE AG

  公开号：US20150218110A1

  公开（公告）日：2015-08-06

  The use of substituted benzodiazepinones and benzazepinones of the general formula (I) or salts thereof where the radicals in the general formula (I) correspond to the definitions given in the description, for enhancing stress tolerance in plants to abiotic stress, for strengthening plant growth and/or for increasing plant yield, and to selected processes for preparing the compounds mentioned above.

  使用通式（I）或其盐的取代苯二氮平酮和苯并氮平酮，其中通式（I）中的基团对应于描述中给出的定义，用于增强植物对非生物胁迫的耐受性，加强植物生长和/或增加植物产量，并选择上述化合物的制备过程。
• Method
  申请人：Norsk Medisinsk Syklotronsenter AS

  公开号：US10869942B2

  公开（公告）日：2020-12-22

  The present invention relates to new and improved methods of synthesizing radiolabelling agents which can be used to label biomolecules for use as radiopharmaceuticals. It further relates to certain novel radiolabelling agents and their use in such methods. PET imaging methods and methods of diagnosis employing such radiolabelling agents form a further aspect of the invention.

  本发明涉及合成放射性标记剂的新方法和改进方法，这些标记剂可用于标记用作放射性药物的生物大分子。本发明还涉及某些新型放射性标记剂及其在此类方法中的应用。PET 成像方法和使用这种放射性标记剂的诊断方法构成了本发明的另一个方面。
• Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof
  申请人：Whitehead Institute for Biomedical Research

  公开号：US11225469B2

  公开（公告）日：2022-01-18

  The present invention provides compounds of Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, pro-drugs, and compositions thereof. Also provided are methods and kits involving the compounds of Formula (I), (II) or (III) for treating diseases associated with the over-expression of phosphoglycerate dehydrogenase (PHGDH) in a subject, such as proliferative diseases (e.g., cancers (e.g., breast cancer, ER negative breast cancer, melanoma, cervical cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases). Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the activity of PHGDH or inhibit the serine biosynthetic pathway, or both.

  本发明提供了式(II)化合物及其药学上可接受的盐、溶液剂、水合物、多晶型、共晶体、同分异构体、立体异构体、同位素标记的衍生物、原药及其组合物。还提供了涉及式(I)、(II)或(III)化合物的方法和试剂盒，用于治疗与受试者体内磷酸甘油脱氢酶（PHGDH）过度表达有关的疾病，如增殖性疾病（如癌症（如乳腺癌、ER阴性乳腺癌、黑色素瘤、宫颈癌）、良性肿瘤、与血管生成有关的疾病、炎症性疾病、自身炎症性疾病和自身免疫性疾病）。使用本发明的化合物或组合物治疗增殖性疾病患者，可抑制 PHGDH 的活性或抑制丝氨酸生物合成途径，或两者兼而有之。
• Traven',V.F. et al., Journal of Organic Chemistry USSR (English Translation), 1966, vol. 2, p. 362 - 363
  作者：Traven',V.F. et al.

  DOI：——

  日期：——