N-methyl-N-Cbz-guanidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-N-Cbz-guanidine
• 英文别名: benzyl N-(N'-methylcarbamimidoyl)carbamate
• 化学式: C₁₀H₁₃N₃O₂
• 分子量: 207.232
• InChiKey: LGIBUZIDVOSDRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-methyl-N-Cbz-guanidine 、 N-甲基-L-脯氨酸 在 N,N'-羰基二咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 120.0h， 以89%的产率得到(S)-N-(N'-Cbz-N-methylcarbamimidoyl)-1-methylpyrrolidine-2-carboxamide
  参考文献：
  名称：

  脯氨酸衍生的胍催化剂形成广泛的氢键结构：溶液和固态研究

  摘要：

  报道了一系列氨基酸衍生的胍有机催化剂的制备及其在 2-羟基-1,4-萘醌与 β-硝基苯乙烯的迈克尔加成中的应用，最大 ee 为 56%。通过使用 X 射线晶体学寻求对该机制的一些了解，并报告了对分子内和分子间氢键的详细研究。

  DOI：

  10.1039/c9ra07508a

文献信息

• [EN] MALT1 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE MALT1 ET LEURS UTILISATIONS
  申请人：UNIV CORNELL

  公开号：WO2017040304A1

  公开（公告）日：2017-03-09

  Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin' s lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis,an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

  本文提供了化合物的化学式(I)及其药物组合物，可用作MALT1抑制剂。还提供了通过给予化合物的化学式(I)来治疗增生性疾病（例如癌症（例如非霍奇金淋巴瘤、弥漫性大B细胞淋巴瘤、MALT淋巴瘤）、良性肿瘤、与血管生成有关的疾病、自身免疫疾病、炎症性疾病、自身炎症性疾病）的方法。
• Echinocandin cyclic peptide derivatives
  申请人：Mizuno Hiroaki

  公开号：US20050181988A1

  公开（公告）日：2005-08-18

  This invention relates to new lipopeptide compound represented by the following general formula (I) wherein R 1 , R 2 , R 3 , R4 and R 5 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or thereapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal. In particular, R 4 is an alkyl moiety which is substituted with an eventually protected and/or further substituted selected from amino, carboxy, guanidino, heterocyclic-carbonyl, alkyl-carbamoyl.

  本发明涉及一种新的脂肽化合物，其通式如下（I），其中R1、R2、R3、R4和R5如描述中所定义，或其盐具有抗微生物活性（特别是抗真菌活性），对β-1,3-葡聚糖合酶的抑制活性，制备方法，包括它的药物组合物，以及预防和/或治疗包括肺孢子虫感染（例如肺孢子虫肺炎）在人类或动物中的传染病的方法。特别地，R4是一种烷基基团，其被氨基、羧基、鸟氨酸、杂环羰基、烷基氨基酰等保护和/或进一步取代。
• EP3341007B1
  申请人：——

  公开号：EP3341007B1

  公开（公告）日：2020-12-23
• [EN] NEW COMPOUND<br/>[FR] NOUVEAU COMPOSE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2003068807A2

  公开（公告）日：2003-08-21

  This invention relates to new lipopeptide compound represented by the following general formula (I) wherein R1, R2, R3, R4 and R5 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or thereapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal. In particular, R4 is an alkyl moiety which is substituted with an eventually protected and/or further substituted selected from amino, carboxy, guanidino, heterocyclic-carbonyl, alkyl-carbamoyl.
• Proline derived guanidine catalysts forge extensive H-bonded architectures: a solution and solid state study
  作者：Zahraa S. Al-Taie、Simon R. Anetts、Jeppe Christensen、Simon J. Coles、Peter N. Horton、Daniel M. Evans、Leigh F. Jones、Frank F. J. de Kleijne、Shaun M. Ledbetter、Yassin T. H. Mehdar、Patrick J. Murphy、Jack A. Wilson

  DOI：10.1039/c9ra07508a

  日期：——

  application to the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 56%. Some insight into the mechanism was sought by using X-ray crystallography and a detailed study of the intra- and intermolecular hydrogen bonding is reported.

  报道了一系列氨基酸衍生的胍有机催化剂的制备及其在 2-羟基-1,4-萘醌与 β-硝基苯乙烯的迈克尔加成中的应用，最大 ee 为 56%。通过使用 X 射线晶体学寻求对该机制的一些了解，并报告了对分子内和分子间氢键的详细研究。