pentafluorophenyl-4-anilino-4-oxobutanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: pentafluorophenyl-4-anilino-4-oxobutanoate
• 英文别名: (2,3,4,5,6-Pentafluorophenyl) 4-anilino-4-oxobutanoate
• 化学式: C₁₆H₁₀F₅NO₃
• 分子量: 359.252
• InChiKey: GVWOGVVJIWPENQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  、 N-苯丁二醯亞胺 、 五氟苯酚 在 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 生成 pentafluorophenyl-4-anilino-4-oxobutanoate 、 pentafluorophenyl-4-anilino-4-oxobutanoate-d5
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS FOR THE RAPID QUANTITATIVE ANALYSIS OF PROTEINS AND POLYPEPTIDES
  [FR] COMPOSES ET PROCEDES D'ANALYSE QUANTITATIVE RAPIDE DE PROTEINES ET DE POLYPEPTIDES

  摘要：

  一种具有公式PRG-Z的多肽反应试剂，其中'PRG'是一个多肽反应基团，可选择性地与捕获试剂结合，而'Z'是芳基、取代芳基、烷基、取代烷基、较低烷基或取代较低烷基基团，其中一个或多个原子可用一个或多个稳定同位素'X'进行不同标记，其中'X'选自包括H和D的组。

  公开号：

  WO2005012247A1

文献信息

• METHODS AND REAGENTS FOR ENRICHMENT AND CHARACTERIZATION OF PHOSPHORYLATED BIOMOLECULES
  申请人：Pshezhetsky Alexey V.

  公开号：US20110223633A1

  公开（公告）日：2011-09-15

  An affinity matrix comprising a metal ion covalently attached thereto and methods for making and using the same are described. The matrix has affinity for various phosphorylated biomolecules, such as phosphoproteins/phosphopeptides. The matrix may be used in a variety of different applications, including phospho-biomolecule (e.g., phosphoprotein and phosphopeptides) enrichment/purification and characterization applications. Also provided are kits and systems that include the matrix.
• [EN] METHODS AND REAGENTS FOR ENRICHMENT AND CHARACTERIZATION OF PHOSPHORYLATED BIOMOLECULES<br/>[FR] MÉTHODES ET RÉACTIFS D'ENRICHISSEMENT ET DE CARACTÉRISATION DE BIOMOLÉCULES PHOSPHORYLÉES
  申请人：CT HOSPITALIER UNIVERSITAIRE S

  公开号：WO2010045710A1

  公开（公告）日：2010-04-29

  An affinity matrix comprising a metal ion covalently attached thereto and methods for making and using the same are described. The matrix has affinity for various phosphorylated biomolecules, such as phosphoproteins/phosphopeptides. The matrix may be used in a variety of different applications, including phospho-biomolecule (e.g., phosphoprotein and phosphopeptides) enrichment/purification and characterization applications. Also provided are kits and systems that include the matrix.