pentafluorophenyl-4-anilino-4-oxobutanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: pentafluorophenyl-4-anilino-4-oxobutanoate
• 英文别名: (2,3,4,5,6-Pentafluorophenyl) 4-anilino-4-oxobutanoate
• 化学式: C₁₆H₁₀F₅NO₃
• 分子量: 359.252
• InChiKey: GVWOGVVJIWPENQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  、 N-苯丁二醯亞胺 、 五氟苯酚 在 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 生成 pentafluorophenyl-4-anilino-4-oxobutanoate 、 pentafluorophenyl-4-anilino-4-oxobutanoate-d5
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS FOR THE RAPID QUANTITATIVE ANALYSIS OF PROTEINS AND POLYPEPTIDES
  [FR] COMPOSES ET PROCEDES D'ANALYSE QUANTITATIVE RAPIDE DE PROTEINES ET DE POLYPEPTIDES

  摘要：

  一种具有公式PRG-Z的多肽反应试剂，其中'PRG'是一个多肽反应基团，可选择性地与捕获试剂结合，而'Z'是芳基、取代芳基、烷基、取代烷基、较低烷基或取代较低烷基基团，其中一个或多个原子可用一个或多个稳定同位素'X'进行不同标记，其中'X'选自包括H和D的组。

  公开号：

  WO2005012247A1

文献信息

• METHODS AND REAGENTS FOR ENRICHMENT AND CHARACTERIZATION OF PHOSPHORYLATED BIOMOLECULES
  申请人：Pshezhetsky Alexey V.

  公开号：US20110223633A1

  公开（公告）日：2011-09-15

  An affinity matrix comprising a metal ion covalently attached thereto and methods for making and using the same are described. The matrix has affinity for various phosphorylated biomolecules, such as phosphoproteins/phosphopeptides. The matrix may be used in a variety of different applications, including phospho-biomolecule (e.g., phosphoprotein and phosphopeptides) enrichment/purification and characterization applications. Also provided are kits and systems that include the matrix.
• [EN] METHODS AND REAGENTS FOR ENRICHMENT AND CHARACTERIZATION OF PHOSPHORYLATED BIOMOLECULES<br/>[FR] MÉTHODES ET RÉACTIFS D'ENRICHISSEMENT ET DE CARACTÉRISATION DE BIOMOLÉCULES PHOSPHORYLÉES
  申请人：CT HOSPITALIER UNIVERSITAIRE S

  公开号：WO2010045710A1

  公开（公告）日：2010-04-29

  An affinity matrix comprising a metal ion covalently attached thereto and methods for making and using the same are described. The matrix has affinity for various phosphorylated biomolecules, such as phosphoproteins/phosphopeptides. The matrix may be used in a variety of different applications, including phospho-biomolecule (e.g., phosphoprotein and phosphopeptides) enrichment/purification and characterization applications. Also provided are kits and systems that include the matrix.
• [EN] COMPOUNDS AND METHODS FOR THE RAPID QUANTITATIVE ANALYSIS OF PROTEINS AND POLYPEPTIDES<br/>[FR] COMPOSES ET PROCEDES D'ANALYSE QUANTITATIVE RAPIDE DE PROTEINES ET DE POLYPEPTIDES
  申请人：CHU SAINTE JUSTINE

  公开号：WO2005012247A1

  公开（公告）日：2005-02-10

  A polypeptide reactive reagent having the formula PRG-Z wherein 'PRG' is a polypeptide reactive group which optionally binds to a capture reagent, and wherein 'Z' is an aryl, substituted aryl, alkyl, substituted alkyl, lower alkyl or substituted lower alkyl group in which one or more atoms can be differentially labeled with one or more stable isotopes 'X', wherein 'X' is selected from the group consisting of H and D, is described.

  一种具有公式PRG-Z的多肽反应试剂，其中'PRG'是一个多肽反应基团，可选择性地与捕获试剂结合，而'Z'是芳基、取代芳基、烷基、取代烷基、较低烷基或取代较低烷基基团，其中一个或多个原子可用一个或多个稳定同位素'X'进行不同标记，其中'X'选自包括H和D的组。