2,4-dideoxy-D-erythro-hexapyranose

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2,4-dideoxy-D-erythro-hexapyranose
• 英文别名: 2,4-dideoxy-β-D-erythrohexopyranose；(2R,4R,6S)-6-(hydroxymethyl)oxane-2,4-diol
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: IMAXLNCKOJCLPF-NGJCXOISSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙醛 、 羟乙醛 在 三乙醇胺 、 乙二胺四乙酸 作用下， 反应 144.0h， 生成 2-deoxy-D-erythro-pentafuranose 、 2,4-dideoxy-D-erythro-hexapyranose
  参考文献：
  名称：

  Sequential Three- and Four-Substrate Aldol Reactions Catalyzed by Aldolases

  摘要：

  This paper describes a useful synthetic strategy based on sequential enzyme-catalyzed aldol addition reactions. The aldol reaction of an acceptor aldehyde with acetaldehyde, catalyzed by 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4), gives a new aldehyde, which subsequently reacts with a second donor substrate, catalyzed by DERA or another aldolase. This sequential aldol reaction proceeds because of the formation of a stable cyclic hemiacetal or hemiketal product. In this way several 6-substituted 2,4,6-trideoxyhexoses have been stereoselectively synthesized via a one-pot double DERA-catalyzed reaction. DERA coupled with fructose-1,6-diphosphate aldolase from rabbit muscle (RAMA, EC 4.1.2.13) in a one-pot reaction gave a variety of 5-deoxyheptuloses, however not in 100% stereoselectivity. The sequential aldol reactions with four substrates were accomplished by coupling DERA with N-acetylneuraminic acid aldolase (NeuAc aldolase, EC 4.1.3.3) to give several nine-carbon sialic acid-type sugar derivatives.

  DOI：

  10.1021/ja00134a001

文献信息

• Antisense oligonucleotides for the inhibition of integrin alphaV-subunit expression
  申请人：Hoechst Marion Roussel Deutschland GmbH

  公开号：EP0950709A1

  公开（公告）日：1999-10-20

  The present invention relates to an oligonucleotide or a derivative thereof which has a sequence that corresponds to a part of a nucleic acid which encodes an integrin αv subunit and which has the ability to induce apoptosis, the preparation and the use thereof.

  本发明涉及一种寡核苷酸或其衍生物，其序列与编码整合素 αv 亚基的核酸的一部分相对应，具有诱导细胞凋亡的能力。
• Immuno stimulating complex and oligonucleotide formulations for inducing enhanced interferon-gamma responses
  申请人：CSL Limited

  公开号：EP2484374A1

  公开（公告）日：2012-08-08

  Vaccine compositions comprising (a) an oligonucleotide, (b) and immune stimulating complex and (c) an antigen induce a strong interferon-gamma immune response. Both oligonucleotides containing immune stimulatory motifs and oligonucleotides lacking immune stimulatory motifs contribute to an interferon-gamma response when administered with an immune stimulating complex.

  由(a)寡核苷酸、(b)免疫刺激复合物和(c)抗原组成的疫苗组合物能诱导强烈的γ干扰素免疫反应。当与免疫刺激复合物一起给药时，含有免疫刺激基团的寡核苷酸和缺乏免疫刺激基团的寡核苷酸都有助于产生干扰素-γ 反应。
• G cap-stabilized oligonucleotides
  申请人：——

  公开号：US20020151512A1

  公开（公告）日：2002-10-17

  Oligonucleotides of the formula 5′-(CAP)-(Oligo)-(CAP)-3′ are disclosed where (oligo) is a nucleotide sequence of from 10 to 40 nucleotides in length, and CAP is G m , where m is an integer of from zero to ten, the two CAP's which are present in the molecule can be defined independently of each other and must be different in the case where m is zero at the 5′ or 3′ end and the end of the Oligo sequence is other than guanine. The oligonucleotides can be synthesized chemically. The oligonucleotides are used to diagnose or treat cancer, restenosis, a disease caused by a virus, a disease affected by integrins or cell-cell adhesion receptor or a disease triggered by diffusible factors.

  式中的寡核苷酸 5′-(CAP)-(寡核苷酸)-(CAP)-3′。 其中（寡核苷酸）是长度为 10 至 40 个核苷酸的核苷酸序列，CAP 是 G m 其中，m 是零到十的整数，分子中存在的两个 CAP 可以彼此独立定义，在 5′ 或 3′ 端 m 为零且寡核苷酸序列的末端不是鸟嘌呤的情况下，这两个 CAP 必须是不同的。寡核苷酸可以化学合成。寡核苷酸可用于诊断或治疗癌症、再狭窄、由病毒引起的疾病、受整合素或细胞-细胞粘附受体影响的疾病或由可扩散因素引发的疾病。
• Oligoribonucleotide derivatives for specific inhibition of gene expression
  申请人：——

  公开号：US20030105052A1

  公开（公告）日：2003-06-05

  The present invention relates to oligoribonucleotide derivatives which have a 2′5′-linked oligoribonucleotide residue without a 5′-phosphate residue on the 3′ end and to the use thereof for specific inhibition of gene expression.

  本发明涉及寡核苷酸衍生物，这种衍生物具有 2′5′连接的寡核苷酸残基，但 3′端没有 5′-磷酸残基，本发明还涉及使用这种衍生物特异性抑制基因表达。
• Synthetic double-stranded oligonucleotides for specific inhibition of gene expression
  申请人：——

  公开号：US20030139585A1

  公开（公告）日：2003-07-24

  The present invention relates to oligonucleotide derivatives which are at least partly double-stranded and which have a 2′5′-linked oligonucleotide residue on at least one 3′ end and to the use thereof for specific inhibition of gene expression.

  本发明涉及至少部分为双链、至少一个 3′端有 2′5′连接的寡核苷酸残基的寡核苷酸衍生物，并涉及用其特异性抑制基因表达。