2-Methyl-butanal-

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methyl-butanal-
• 英文别名: 2-Methyl-butanal-；2-Methyl-butanal-toluolsulfonyl-(4)-hydrazon；4-methyl-N-(2-methylbutylideneamino)benzenesulfonamide
• 化学式: C₁₂H₁₈N₂O₂S
• 分子量: 254.353
• InChiKey: ZXPSDOVTZIXUBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Methyl-butanal- 在 吡啶 、 羟基甲苯磺酰碘苯 作用下， 以 二氯甲烷 为溶剂， 以39%的产率得到3,6-di-sec-butyl-1,4-bis(tosyl)-1,4-dihydro-1,2,4,5-tetrazine
  参考文献：
  名称：

  使用[羟基（甲苯磺酰氧基）碘]苯由新型合成3,6-二取代-1,2,4,5-四嗪衍生物

  摘要：

  温和和有效的协议的1,4-二氢-3,6-二取代-1,4-双（施工p甲苯磺酰）从-1,2,4,5-四嗪p甲苯磺酰腙由[羟基介导的已经开发了在吡啶存在下的（甲苯磺酰氧基）碘]苯。该协议以良好的产量提供了优良的产品。通过对甲苯磺酰基的一步N-脱保护和在THF中用四丁基氟化铵进行芳构化，可以轻松获得相应的3,6-二取代-1,2,4,5-四嗪。已经提出了一种机制。

  DOI：

  10.1016/j.tetlet.2013.06.053
• 作为产物：
  描述：

  2-甲基丁醛 、 对甲苯磺酰肼 以 甲醇 为溶剂， 反应 0.5h， 生成 2-Methyl-butanal-
  参考文献：
  名称：

  Multicomponent Coupling Reactions of Two N-Tosyl Hydrazones and Elemental Sulfur: Selective Denitrogenation Pathway toward Unsymmetric 2,5-Disubstituted 1,3,4-Thiadiazoles

  摘要：

  A copper-mediated, three-component reaction between two different N-Ts hydrazones and elemental sulfur was developed, leading to a series of unsymmetric 2,5-disubstituted 1,3,4-thiadiazoles in moderate yields with good functional group compatibility. This procedure features the employment of elemental sulfur and the selective denitrogenation between aryl and alkyl aldehyde N-tosyl hydrazones, allowing rapid access to unsymmetric 2,5-disubstituted 1,3,4-thiadiazoles frameworks with chemical diversity and complexity.

  DOI：

  10.1021/acs.orglett.6b02583

文献信息

• Multicomponent Coupling Reactions of Two <i>N</i>-Tosyl Hydrazones and Elemental Sulfur: Selective Denitrogenation Pathway toward Unsymmetric 2,5-Disubstituted 1,3,4-Thiadiazoles
  作者：Zhen Zhou、Yang Liu、Jiangfei Chen、En Yao、Jiang Cheng

  DOI：10.1021/acs.orglett.6b02583

  日期：2016.10.21

  A copper-mediated, three-component reaction between two different N-Ts hydrazones and elemental sulfur was developed, leading to a series of unsymmetric 2,5-disubstituted 1,3,4-thiadiazoles in moderate yields with good functional group compatibility. This procedure features the employment of elemental sulfur and the selective denitrogenation between aryl and alkyl aldehyde N-tosyl hydrazones, allowing rapid access to unsymmetric 2,5-disubstituted 1,3,4-thiadiazoles frameworks with chemical diversity and complexity.
• Novel synthesis of 3,6-disubstituted-1,2,4,5-tetrazine derivatives from hydrazones by using [hydroxyl(tosyloxy)iodo]benzene
  作者：Haixuan Liu、Yunyang Wei

  DOI：10.1016/j.tetlet.2013.06.053

  日期：2013.8

  A mild and efficient protocol for the construction of 1,4-dihydro-3,6-disubstituted-1,4-bis(p-toluenesulfonyl)-1,2,4,5-tetrazines from p-toluenesulfonyl hydrazones mediated by [hydroxyl(tosyloxy)iodo]benzene in the presence of pyridine has been developed. This protocol affords the products in good to excellent yields. The corresponding 3,6-disubstituted-1,2,4,5-tetrazines can be easily obtained through

  温和和有效的协议的1,4-二氢-3,6-二取代-1,4-双（施工p甲苯磺酰）从-1,2,4,5-四嗪p甲苯磺酰腙由[羟基介导的已经开发了在吡啶存在下的（甲苯磺酰氧基）碘]苯。该协议以良好的产量提供了优良的产品。通过对甲苯磺酰基的一步N-脱保护和在THF中用四丁基氟化铵进行芳构化，可以轻松获得相应的3,6-二取代-1,2,4,5-四嗪。已经提出了一种机制。