diethyl 4-(furan-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: diethyl 4-(furan-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 英文别名: 4-<β-Furyl>-2,6-dimethyl-3,5-bis-aethoxycarbonyl-1,4-dihydropyridin；4-(β-Furyl)-2,6-dimethyl-3,5-bis-aethoxycarbonyl-1,4-dihydropyridin；Diethyl 4-(furan-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylate
• 化学式: C₁₇H₂₁NO₅
• 分子量: 319.357
• InChiKey: SGSIFWJAOSJXHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  77.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-糠醛 、 乙酰乙酸乙酯 在 cobalt(II) chloride hexahydrate 、 ammonium acetate 作用下， 以 水 为溶剂， 反应 1.17h， 以70%的产率得到diethyl 4-(furan-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  参考文献：
  名称：

  Synthesis of diethyl 4-(phenyl-substituted)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates catalyzed by CoCl2/K-10 montmorillonite in water and their antimicrobial activity

  摘要：

  A simple and efficient method of one pot synthesis of 1,4-dihydropyridine by three components reaction of aromatic aldehydes with 1,3-dicarbonyl compound, ammonium acetate and catalytic amount of CoCl2 based on the Hantszch reaction is developed. The process is catalysis by an inexpensive catalyst in water medium, gives high yield of products and involves no volatile organic solvents. Some synthesized compounds demonstrated antimicrobial activity.

  DOI：

  10.1134/s1070363217030264

文献信息

• SUBSTITUTED HETEROCYCLIC COMPOUNDS
  申请人：Abelman Matthew

  公开号：US20090012103A1

  公开（公告）日：2009-01-08

  The present invention relates to novel heterocyclic compounds and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (I): wherein Q1, Q2, R2, R3, R4, R5, and R6 are as described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.

  本发明涉及新颖的杂环化合物及其在治疗各种疾病状态中的应用，包括心血管疾病和糖尿病。在特定实施例中，化合物的结构由公式（I）给出：其中Q1、Q2、R2、R3、R4、R5和R6如本文所述。该发明还涉及制备这些化合物的方法，以及含有这些化合物的药物组合物。
• US8716319B2
  申请人：——

  公开号：US8716319B2

  公开（公告）日：2014-05-06
• US9045428B2
  申请人：——

  公开号：US9045428B2

  公开（公告）日：2015-06-02