1,1-diethylbut-3-enylamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1-diethylbut-3-enylamine
• 英文别名: 4-ethylhexen-1-en-4-amine；3-Ethylhex-5-en-3-amine
• 化学式: C₈H₁₇N
• mdl: MFCD19204826
• 分子量: 127.23
• InChiKey: XFRZKBYJCVXIGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1-diethylbut-3-enylamine 在 2,6-二甲基吡啶 、 过氧化双月桂酰 、 三乙胺 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 生成 6-chloro-4-(4,4-dimethyl-3-oxopentyl)-2,2-diethyl-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-8-(2H)-one
  参考文献：
  名称：

  Carbon Radical Attack on a Pyrimidine Nitrogen. An Unusual Entry into Polycyclic Aminopyrimidones

  摘要：

  Unprecedented examples of a synthetically useful radical ring closure onto a pyrimidine nitrogen leading to novel, highly functionalized bi- and tricyclic pyrimidone structures are reported. An unexpected hydrogen atom translocation prior to the cyclization step was observed in some cases.

  DOI：

  10.1021/ol501104h
• 作为产物：
  描述：

  Methyl N-(1,1-diethyl-3-buten-1-yl)carbamate 在 potassium hydroxide 、 肼 作用下， 以 乙二醇 为溶剂， 生成 1,1-diethylbut-3-enylamine
  参考文献：
  名称：

  Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists

  摘要：

  Administration of Neuropeptide S (NPS) has been shown to produce arousal, that is, independent of novelty and to induce wakefulness by suppressing all stages of sleep, as demonstrated by EEG recordings in rat. Medicinal chemistry efforts have identified a quinolinone class of potent NPSR antagonists that readily cross the blood-brain barrier. We detail here optimization efforts resulting in the identification of a potent NPSR antagonist which dose-dependently and specifically inhibited (125)I-NPS binding in the CNS when administered to rats. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.143

文献信息

• Diastereoselective allylation and crotylation of N-unsubstituted imines derived from ketones
  作者：Bhartesh Dhudshia、Jorge Tiburcio、Avinash N. Thadani

  DOI：10.1039/b511411j

  日期：——

  A wide variety of tertiary carbinamines are synthesized in high yields via diastereoselective allylation and crotylation of in situ generated N-unsubstituted ketimines.

  通过立体选择性的烯丙基化和巴豆基化反应，在原位生成了未取代的N-酮亚胺，进而高效合成了多种叔碳胺。
• METHODS OF PREPARING TERTIARY CARBINAMINE COMPOUNDS
  申请人：Thadani Avinash N.

  公开号：US20080139847A1

  公开（公告）日：2008-06-12

  The present invention relates to a method for the preparation of tertiary carbinamine compounds from diastereoselective allylation and crotylation of N-unsubstituted imines derived from ketones.

  本发明涉及一种从酮衍生的N-未取代亚胺的立体选择性烯丙基化反应和烯丙基化反应制备三级碳胺化合物的方法。
• US8143451B2
  申请人：——

  公开号：US8143451B2

  公开（公告）日：2012-03-27
• Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists
  作者：Jeffrey Y. Melamed、Amy E. Zartman、Nathan R. Kett、Anthony L. Gotter、Victor N. Uebele、Duane R. Reiss、Cindra L. Condra、Christine Fandozzi、Laura S. Lubbers、Blake A. Rowe、Georgia B. McGaughey、Martin Henault、Rino Stocco、John J. Renger、George D. Hartman、Mark T. Bilodeau、B. Wesley Trotter

  DOI：10.1016/j.bmcl.2010.04.143

  日期：2010.8

  Administration of Neuropeptide S (NPS) has been shown to produce arousal, that is, independent of novelty and to induce wakefulness by suppressing all stages of sleep, as demonstrated by EEG recordings in rat. Medicinal chemistry efforts have identified a quinolinone class of potent NPSR antagonists that readily cross the blood-brain barrier. We detail here optimization efforts resulting in the identification of a potent NPSR antagonist which dose-dependently and specifically inhibited (125)I-NPS binding in the CNS when administered to rats. (C) 2010 Elsevier Ltd. All rights reserved.
• Carbon Radical Attack on a Pyrimidine Nitrogen. An Unusual Entry into Polycyclic Aminopyrimidones
  作者：Ling Qin、Zhibo Liu、Samir Z. Zard

  DOI：10.1021/ol501104h

  日期：2014.6.6

  Unprecedented examples of a synthetically useful radical ring closure onto a pyrimidine nitrogen leading to novel, highly functionalized bi- and tricyclic pyrimidone structures are reported. An unexpected hydrogen atom translocation prior to the cyclization step was observed in some cases.