N1-hexyl biguanide hydrochloride | 4838-52-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N1-hexyl biguanide hydrochloride
• 英文别名: 1-hexylbiguanidium chloride；Biguanide, 1-hexyl-, monohydrochloride；1-(diaminomethylidene)-2-hexylguanidine;hydrochloride
• CAS: 4838-52-2
• 化学式: C₈H₁₉N₅*ClH
• 分子量: 221.733
• InChiKey: IVUDUFNBXCHCOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.66
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  105
• 氢给体数：
  4
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  正己胺 、 二聚氰胺 在 iron(III) chloride 、 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 以99%的产率得到N1-hexyl biguanide hydrochloride
  参考文献：
  名称：

  烷基双胍盐诱导的膜透化和扰动

  摘要：

  摘要 烷基双胍盐对简单的磷脂双层（脂质体）和复杂的磷脂膜（细菌膜）显示出膜扰动特性。与二甲双胍和苯乙双胍相比，烷基双胍盐诱导磷脂膜更显着的透化，导致高度选择性的 H+/OH- 离子传输和随后的膜去极化。尽管具有较短 C6 和 C8 链的烷基双胍盐亲水性太强而无法插入膜并干扰膜，但具有 C10、C12、C14 和 C16 烷基链的烷基双胍盐显示出较高的膜透化和去极化活性。此外，C10、C12 和 C14 化合物具有令人感兴趣的抗菌活性，并且在接近其最小抑制浓度的浓度下，它们显示出较低的溶血活性和毒性。

  DOI：

  10.1080/10610278.2018.1535710

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• ANTIBACTERIAL HYDROPHILIC COMPOUND AND USE THEREOF
  申请人：SHENZHEN UNIVERSITY

  公开号：US20200093124A1

  公开（公告）日：2020-03-26

  The present disclosure provides an antibacterial hydrophilic compound. The antibacterial hydrophilic compound may react, induced by light through a hydrogen abstraction group in the structural formula thereof, with a C—H group and thus bind to a surface of a material having the C—H group (for example, chemical fibers such as polyester, chinlon, and the like; plastics, rubbers, and other similar materials), which can impart a durable antibacterial activity and hydrophilicity to the material. The antibacterial hydrophilic compound has a relatively strong binding force to the surface of the material without damaging the mechanical properties of the raw material. The present disclosure also provides a modified material that is modified by the antibacterial hydrophilic compound.

  本公开提供一种抗菌亲水化合物。该抗菌亲水化合物可以通过其结构式中的氢抽取基团受光诱导反应，与C—H基团发生作用，从而结合到具有C—H基团的材料表面（例如，化学纤维如涤纶、尼龙等；塑料、橡胶和其他类似材料），从而赋予材料耐久的抗菌活性和亲水性。该抗菌亲水化合物对材料表面具有相对较强的结合力，而不会损害原材料的机械性能。本公开还提供一种由该抗菌亲水化合物改性的材料。
• Silver dihydrogen citrate compositions
  申请人：Arata B. Andrew

  公开号：US20060051430A1

  公开（公告）日：2006-03-09

  Personal care and home care compositions are disclosed, which include silver dihydrogen citrate. The inventive compositions advantageously take the form of suspensions, pastes, liquids and gels. The inventive compositions also optionally comprise additional ingredients, and are therefore suitable for a wide variety of personal, home and industrial care purposes.

  护理和家居用品组合物被披露，其中包括柠檬酸二氢银。这种创新的组合物有利地采用悬浮液、糊状物、液体和凝胶的形式。这些创新的组合物还可以选择性地包含额外的成分，因此适用于各种个人、家庭和工业护理用途。
• [EN] AGRICULTURAL APPLICATIONS OF SILVER DIHYDROGEN CITRATE<br/>[FR] APPLICATIONS AGRICOLES DU DIHYDROGÉNOCITRATE D'ARGENT
  申请人：PURE BIOSCIENCE

  公开号：WO2009148469A1

  公开（公告）日：2009-12-10

  A method for treating a plant, the method comprising contacting a composition comprising silver dihydrogen citrate with at least one of the plant, a portion of soil and/or groundwater proximal to the plant, or a combination thereof.

  一种治疗植物的方法，该方法包括将含有双氢柠檬酸银的组合物与植物之一、植物附近的土壤和/或地下水的部分，或两者的组合物接触。
• Alkoxy disulfides as antimicrobial agents
  申请人：ROHM AND HAAS COMPANY

  公开号：EP1008296A1

  公开（公告）日：2000-06-14

  Disclosed is a method of inhibiting the growth of microorganisms in, at, or on a locus subject to microbial attack, comprising introducing to said locus an antimicrobially effective amount of at least one alkoxy disulfide of formula:R1-CHR3-O-S-S-O-CHR4-R2 wherein: R1, R2are independently selected from 5- or 6-membered aromatic rings, optionally substituted with up to 3 e· donating substituents of which 2 can optionally be combined to form another ring; and R3, R4are independently selected from H, CH3, or CH2CH3.

  揭示了一种抑制微生物在受微生物攻击的位置生长的方法，包括向该位置引入至少一种符合以下式的烷氧基二硫化物的抗微生物有效量：R1-CHR3-O-S-S-O-CHR4-R2其中：R1，R2分别选自5-或6-成员芳香环，可选择地取代多达3个e·供体取代基，其中2个可选择地结合形成另一个环；而R3，R4分别选自H，CH3或CH2 。