pyridine-4-carboxaldehyde 2,4-dinitrophenylhydrazone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: pyridine-4-carboxaldehyde 2,4-dinitrophenylhydrazone
• 英文别名: 2,4-dinitro-N-(pyridin-4-ylmethylideneamino)aniline
• 化学式: C₁₂H₉N₅O₄
• 分子量: 287.235
• InChiKey: ZWVUDEXLGCVZEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  129
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-吡啶甲醛 、 2,4-二硝基苯肼 以 乙醇 为溶剂， 以95%的产率得到pyridine-4-carboxaldehyde 2,4-dinitrophenylhydrazone
  参考文献：
  名称：

  Potent antimicrobial agents against azole-resistant fungi based on pyridinohydrazide and hydrazomethylpyridine structural motifs

  摘要：

  Schiff base derivatives have recently been shown to possess antimicrobial activity, and these derivatives include a limited number of salicylaldehyde hydrazones. To further explore this structure-activity relationship between salicylaldehyde hydrazones and antifungal activity, we previously synthesized and analyzed a large series of salicylaldehyde and formylpyridinetrione hydrazones for their ability to inhibit fungal growth of both azole-susceptible and azole-resistant species of Candida. While many of these analogs showed excellent growth inhibition with low mammalian cell toxicity, their activity did not extend to azole-resistant species of Candida. To further dissect the structural features necessary to inhibit azole-resistant fungal species, we synthesized a new class of modified salicylaldehyde derivatives and subsequently identified a series of modified pyridine-based hydrazones that had potent fungicidal antifungal activity against multiple Candida spp. Here we would like to present our synthetic procedures as well as the results from fungal growth inhibition assays, mammalian cell toxicity assays, time-kill assays and synergy studies of these novel pyridine-based hydrazones on both azole-susceptible and azole-resistant fungal species. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.04.040

文献信息

• Ring transformation of cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dionylium ion to the corresponding pyrrole derivatives via troponeimine intermediates: photo-induced autorecycling oxidizing reactions of some amines
  作者：Shin-ichi Naya、Makoto Nitta

  DOI：10.1016/j.tet.2004.07.063

  日期：2004.10

  troponeimine intermediates. Furthermore, novel photo-induced oxidation reactions of a series of 4+·BF4−, 5+·BF4−, and 6a,e+·BF4− towards some amines under aerobic conditions were carried out to give the corresponding imines in 455–8362% yields [based on compounds 4+, 5+, and 6a,e+], suggesting the oxidation reaction occurs in an autorecycling process. Mechanistic aspects of the amine-oxidation reaction are also

  7,9- dimethylcyclohepta [环转化b ]嘧啶并[5,4- d ]呋喃8（7 ħ），10（9 ħ）-dionylium四氟硼酸盐4 + · BF 4 -到-7,9- dimethylcyclohepta [ b ]嘧啶并[5,4- d ] pyrrrole-8（7 ħ），10（9 ħ）-dionylium四氟硼酸6A - d + · BF 4 -由反应4 + · BF 4 -与胺和随后的交换使用aq的抗衡离子。HBF4。的反应4 + · BF 4 -与得到相应的吡咯衍生物苯胺和4-位取代的苯胺6A - C ^ + · BF 4 -直接在良好的产率。的，另一方面，反应4 + · BF 4 -与苄胺，得到中间体troponeimine 9，这是不转化成6D + · BF 4 -和收归4 + · BF 4 -通过加入 ; 然而，它被转换到图6d + · BF 4 -与（氯化钴）处理后2或的SOCl
• Simultaneous Determination of Ozone and Carbonyls Using <i>trans</i>-1,2-Bis(4-pyridyl)ethylene as an Ozone Scrubber for 2,4-Dinitrophenylhydrazine-Impregnated Silica Cartridge
  作者：Shigehisa Uchiyama、Yasufumi Otsubo

  DOI：10.1021/ac702475s

  日期：2008.5.1

  A new method for the simultaneous determination of ozone and carbonyls in air using a two-bed cartridge system has been developed. Each bed consists of reagent-impregnated silica particles. The first contains trans-1,2-bis-(4-pyridyl) ethylene (BPE) while the second contains 2,4-dinitrophenylhydrazine (DNPH). Air samples are drawn through the cartridge first through the BPE and then through the DNPH

  开发了一种使用两床滤芯系统同时测定空气中臭氧和羰基的新方法。每个床由试剂浸渍的二氧化硅颗粒组成。第一种包含反式1,2-双-（4-吡啶基）乙烯（BPE），第二种包含2,4-二硝基苯肼（DNPH）。空气样本首先通过BPE，然后通过DNPH，通过药筒抽取。空气样品中的臭氧被BPE涂层的二氧化硅颗粒捕集在第一层床中，并产生4-醛吡啶。空气中的羰基化合物不受阻碍地通过BPE，并被DNPH涂层的二氧化硅颗粒截留在第二个床层中。它们产生羰基2,4-DNPhydr。DNPH和羰基2,4-DNP azo酮不受BPE的影响，因此不受臭氧的影响。提取是在与空气采样相反的方向进行的。当溶剂通过BEP / DNPH柱被洗脱时，过量的DNPH被洗入BPE床中，在此处它与4-吡啶吡啶反应并形成相应的衍生物。所有衍生自空气中羰基化合物和吡啶-4-醛（源自臭氧）的均被完全分离，并使用高效液相色谱法进行测量。使用Ascentis