2-methyl-5-<4-<2-(3,4,5-trimethoxyphenyl)ethyl>phenyl>imidazo<2,1-a>isoquinoline

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-methyl-5-<4-<2-(3,4,5-trimethoxyphenyl)ethyl>phenyl>imidazo<2,1-a>isoquinoline
• 英文别名: 2-Methyl-5-{4-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-phenyl}-imidazo[2,1-a]isoquinoline；2-methyl-5-[4-[2-(3,4,5-trimethoxyphenyl)ethyl]phenyl]imidazo[2,1-a]isoquinoline
• 化学式: C₂₉H₂₈N₂O₃
• 分子量: 452.553
• InChiKey: JECYCJDICVLYQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  45
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-methyl-5-[4-[2-(3,4,5-trimethoxyphenyl)ethyl]phenyl]-3,6-dihydro-2H-imidazo[2,1-a]isoquinolin-5-ol 在 manganese(IV) oxide 、 对甲苯磺酸 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 64.0h， 生成 2-methyl-5-<4-<2-(3,4,5-trimethoxyphenyl)ethyl>phenyl>imidazo<2,1-a>isoquinoline
  参考文献：
  名称：

  Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists

  摘要：

  In an effort to determine the effect of modification of the imidazo[2,1-a]isoquinoline portion of the PAF-receptor antagonist SDZ 64-412 (1), several new analogs were prepared and evaluated in vitro and in vivo. One of these, 5-[4-[2-(3,4,5-trimethoxyphenyl)ethyl]phenyl]-2,3-dihydroimidazo[1,2-a]thieno[2,3-c]pyridine (6) was 4-5 times more potent than 1 in inhibiting PAF-induced bronchoconstriction and hemoconcentration when administered po to the guinea pig.

  DOI：

  10.1021/jm00073a008

文献信息

• Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists
  作者：William J. Houlihan、Seung H. Cheon、Vincent A. Parrino、Dean A. Handley、Douglas A. Larson

  DOI：10.1021/jm00073a008

  日期：1993.10

  In an effort to determine the effect of modification of the imidazo[2,1-a]isoquinoline portion of the PAF-receptor antagonist SDZ 64-412 (1), several new analogs were prepared and evaluated in vitro and in vivo. One of these, 5-[4-[2-(3,4,5-trimethoxyphenyl)ethyl]phenyl]-2,3-dihydroimidazo[1,2-a]thieno[2,3-c]pyridine (6) was 4-5 times more potent than 1 in inhibiting PAF-induced bronchoconstriction and hemoconcentration when administered po to the guinea pig.