N-(3-pyridylmethylidene)-2-methoxyaniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-pyridylmethylidene)-2-methoxyaniline
• 化学式: C₁₃H₁₂N₂O
• 分子量: 212.251
• InChiKey: ZCCHUQACOQUSSB-XNTDXEJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.84
• 重原子数：
  16.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  34.48
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  反-1-甲氧基-3-(三甲基硅氧基)-1,3-丁二烯 、 N-(3-pyridylmethylidene)-2-methoxyaniline 在 (+)-2-[(2-Ph₂PPhC=)N]-3-methylpentanoic acid 4-MeOPh-amide 、 silver(I) acetate 作用下， 以 四氢呋喃 、 异丙醇 为溶剂， 生成 (-)-1-(2-methoxyphenyl)-2,3-dihydro-1H-[2,3']bipyridinyl-4-one 、 (+)-1-(2-methoxyphenyl)-2,3-dihydro-1H-[2,3']bipyridinyl-4-one
  参考文献：
  名称：

  Efficient and Practical Ag-Catalyzed Cycloadditions between Arylimines and the Danishefsky Diene

  摘要：

  An efficient Ag-catalyzed method for asymmetric addition of the Danishefsky diene to various aryl imines to afford cycloadducts in > or =89% ee and > or =85% isolated yield is reported. Reactions are effected with 0.1-1 mol % catalyst (4 degrees C), and the chiral ligand is readily prepared from commercially available materials, including the inexpensive i-Leu. These catalytic asymmetric cycloadditions can be carried out without the use of solvent or with undistilled THF in air. A first generation supported chiral catalyst that effectively promotes the cycloaddition reaction and can be recycled (five cycles) is described.

  DOI：

  10.1021/ja030033p

文献信息

• POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES
  申请人：Bridgestone Corporation

  公开号：EP2969593A1

  公开（公告）日：2016-01-20
• Polymers Functionalized With Heterocyclic Imines
  申请人：BRIDGESTONE CORPORATION

  公开号：US20160039958A1

  公开（公告）日：2016-02-11

  A method for preparing a functionalized polymer, the method comprising the steps of: (i) polymerizing monomer to form a reactive polymer, and (ii) reacting the reactive polymer with an imine compound containing a heterocyclic group and a hydrocarbyloxy-substituted or silyloxy-substituted aryl group.
• US9850328B2
  申请人：——

  公开号：US9850328B2

  公开（公告）日：2017-12-26
• [EN] POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES<br/>[FR] POLYMÈRES FONCTIONNALISÉS PAR DES IMINES HÉTÉROCYCLIQUES
  申请人：BRIDGESTONE CORP

  公开号：WO2014149931A1

  公开（公告）日：2014-09-25

  A method for preparing a functionalized polymer, the method comprising the steps of: (i) polymerizing monomer to form a reactive polymer, and (ii) reacting the reactive polymer with an imine compound containing a heterocyclic group and a hydrocarbyloxy-substituted or silyloxy-substituted aryl group.
• Efficient and Practical Ag-Catalyzed Cycloadditions between Arylimines and the Danishefsky Diene
  作者：Nathan S. Josephsohn、Marc L. Snapper、Amir H. Hoveyda

  DOI：10.1021/ja030033p

  日期：2003.4.1

  An efficient Ag-catalyzed method for asymmetric addition of the Danishefsky diene to various aryl imines to afford cycloadducts in > or =89% ee and > or =85% isolated yield is reported. Reactions are effected with 0.1-1 mol % catalyst (4 degrees C), and the chiral ligand is readily prepared from commercially available materials, including the inexpensive i-Leu. These catalytic asymmetric cycloadditions can be carried out without the use of solvent or with undistilled THF in air. A first generation supported chiral catalyst that effectively promotes the cycloaddition reaction and can be recycled (five cycles) is described.