1-acetyl-pyrimidinium chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-acetyl-pyrimidinium chloride
• 英文别名: 1-Pyrimidin-1-ium-1-ylethanone;chloride
• 化学式: C₆H₇N₂O*Cl
• 分子量: 158.587
• InChiKey: QHEYIILDCBUZSG-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.97
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  33.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-苯基-1-三甲基硅氧乙烯 、 1-acetyl-pyrimidinium chloride 、 乙酰氯 以 乙腈 为溶剂， 反应 5.0h， 生成 1,3-diacetyl-2,4-diphenacyl-1,2,3,4-tetrahydropyrimidine
  参考文献：
  名称：

  用嘧啶鎓盐和烯醇甲硅烷基醚合成带有2-氧代烷基的四氢嘧啶：形成二氮杂双环[3.3.1] nona-3,6-diene衍生物

  摘要：

  进行N-甲硅烷基-或N-酰基-嘧啶鎓盐与烯醇三甲基甲硅烷基醚的反应，得到具有2-氧代烷基的加​​合物，即2-羟基-4-（2-氧代烷基）-1，2， 3，4-四氢嘧啶（9）或3-酰基衍生物（8）。化合物（9）的单酰化以高收率得到单酰胺（8）。在吡啶存在下用大量过量的2,2,2-三氯乙基氯甲酸将二胺（9）彻底酰化，得到双环化合物2-oxa-8,9-diazabicyclo [3.3.1] nona-3,6-dienes （14）。通过添加三氟乙酸，化合物（14）被重新打开以提供3,4-二氢嘧啶盐（11 '），将其进行亲核攻击以高收率得到1,2,3,4-四氢嘧啶（16）。

  DOI：

  10.1039/p19880000725
• 作为产物：
  描述：

  嘧啶 、 乙酰氯 以 乙腈 为溶剂， 反应 0.25h， 生成 1-acetyl-pyrimidinium chloride
  参考文献：
  名称：

  用嘧啶鎓盐和烯醇甲硅烷基醚合成带有2-氧代烷基的四氢嘧啶：形成二氮杂双环[3.3.1] nona-3,6-diene衍生物

  摘要：

  进行N-甲硅烷基-或N-酰基-嘧啶鎓盐与烯醇三甲基甲硅烷基醚的反应，得到具有2-氧代烷基的加​​合物，即2-羟基-4-（2-氧代烷基）-1，2， 3，4-四氢嘧啶（9）或3-酰基衍生物（8）。化合物（9）的单酰化以高收率得到单酰胺（8）。在吡啶存在下用大量过量的2,2,2-三氯乙基氯甲酸将二胺（9）彻底酰化，得到双环化合物2-oxa-8,9-diazabicyclo [3.3.1] nona-3,6-dienes （14）。通过添加三氟乙酸，化合物（14）被重新打开以提供3,4-二氢嘧啶盐（11 '），将其进行亲核攻击以高收率得到1,2,3,4-四氢嘧啶（16）。

  DOI：

  10.1039/p19880000725

文献信息

• Novel topical skin care and nutraceutical applications of Glabridin or extracts containing a defined amount (4-90%) of Glabridin
  申请人：——

  公开号：US20040121031A1

  公开（公告）日：2004-06-24

  This application is a continuation-in-part of pending U.S. patent application Ser. No. 10/065,995 by the authors, filed on Dec. 9, 2002, for a Commercial Process for Isolation and Purification of Glabridin with High Tyrosinase Inhibitory Activity and its Cosmetic Compositions and Methods Of Use. The current invention discloses the use of Glabridin containing Licorice extract (4-90% Glabridin) as metalloprotease and hyaluronidase inhibiting component in cosmetic topical or oral formulations. These extracts and particularly Glabridin, are useful in anti-wrinkle and anti-aging products, providing elasticity, firmness, tone and texture to the skin, ameliorating fine lines and crows feet in under eye preparations, and prevent skin and hair damage due to UV rays, inflammation and itch, diaper rashes in baby products, as massage or toning oils or emulsion for babies.
• [EN] AN AQUEOUS LAUNDRY TREATMENT COMPOSITION<br/>[FR] COMPOSITION DE TRAITEMENT DE LINGE LIQUIDE ACQUEUSE
  申请人：UNILEVER IP HOLDINGS B V

  公开号：WO2021219351A1

  公开（公告）日：2021-11-04

  The present invention relates to an aqueous laundry treatment composition. Particularly, the present invention relates to an aqueous laundry treatment composition for removing germs from a fabric. The composition comprises (a) from 0.5 to 5 wt% of one or more quaternary ammonium compound, ( b) from 0.1 to 5 wt% of one or more organic acid having pKa in the range from 1 to 5.5, ( c) from 1 to 5 wt% of a peroxide, and ( d) from 0.5 to 5 wt% ethoxylated amine with saturated or unsaturated alkyl groups having carbon atoms in the range from 12 to 22 and 1 to 50 ethoxylate groups.
• [EN] METHOD FOR MICROBIOME BALANCING<br/>[FR] PROCÉDÉ POUR ÉQUILIBRER LE MICROBIOME
  申请人：[en]UNILEVER IP HOLDINGS B.V.

  公开号：WO2022084207A1

  公开（公告）日：2022-04-28

  The present invention relates to use of a composition comprising a quaternary ammonium compound and a licorice extract in microbiome balancing on a surface, wherein balancing means selectively reducing the number of microbes selected from Escherichia Coli and Staphylococcus aureus, while having less effect on or selectively increasing the number of microbes of Staphylococcus Epidermidis; wherein the licorice extract is glycyrrhiza root extract; wherein the weight ratio of the quaternary ammonium compound to the licorice extract ranges from 1:5000 to 1:100; and wherein the quaternary ammonium compound comprises didecyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, alkyl dimethyl benzyl ammonium chloride, diisobutyl phenoxy ethoxy ethyl dimethyl benzyl ammonium chloride, alkyl dimethyl benzyl ammonium saccharinate, octyl decyl dimethyl ammonium chloride, alkyl dimethyl ethyl benzyl ammonium chloride, methyldodecylbenzyl ammonium chloride, methyldodecylxylene-bis-trimethyl ammonium chloride, methyl benzethonium chloride, cetyl pyrinidinium chloride, cetrimonium bromide or mixtures thereof.
• [EN] LIQUID AQUEOUS CLEANING COMPOSITION<br/>[FR] COMPOSITION DE NETTOYAGE AQUEUSE LIQUIDE
  申请人：[en]UNILEVER IP HOLDINGS B.V.

  公开号：WO2022096260A1

  公开（公告）日：2022-05-12

  The present invention relates a liquid aqueous cleaning composition comprising quaternary ammonium compound, hydrogen peroxide and organic acid having a pKa of from 1 to 5.5. The composition has a pH of 2 to 5 and a viscosity at 25°C of 1 to 1000 mPa.s @ 20 s-1and the composition is free of anionic surfactant.
• [EN] AQUEOUS ALKALINE ABRASIVE CLEANING COMPOSITION<br/>[FR] COMPOSITION DE NETTOYAGE AQUEUSE ALCALINE ABRASIVE
  申请人：[en]UNILEVER IP HOLDINGS B.V.

  公开号：WO2022100982A1

  公开（公告）日：2022-05-19

  The present invention relates to aqueous alkaline abrasive cleaning compositions comprising quaternary ammonium compound that are stable over time.