1-amino-2,4-di(allylthio)naphthalene

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-amino-2,4-di(allylthio)naphthalene
• 英文别名: 2,4-Bis(prop-2-enylsulfanyl)naphthalen-1-amine；2,4-bis(prop-2-enylsulfanyl)naphthalen-1-amine
• 化学式: C₁₆H₁₇NS₂
• 分子量: 287.45
• InChiKey: VEKIBJJSJYOLQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  76.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  烯丙硫醇 、 硝基萘 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N-二(三甲基硅基)乙酰胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 336.0h， 以60%的产率得到1-amino-4-(allylthio)naphthalene
  参考文献：
  名称：

  Double thioalkylation/arylation of nitroarenes with the reduction of nitro- to amino group

  摘要：

  Some active bicyclic nitroarenes readily react with an excess of alkyl/arylthiols in the presence of DBU and bis-trimethylsilylacetamide (BSA) in DMF solution, to give dithioalkyl/aryl substituted anilines in moderate to good yields via displacement of ortho- and para-hydrogen atoms with simultaneous reduction of the nitro- to amino-group. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)01454-0

文献信息

• Double thioalkylation/arylation of nitroarenes with the reduction of nitro- to amino group
  作者：Zbigniew Wróbel

  DOI：10.1016/s0040-4020(02)01454-0

  日期：2003.1

  Some active bicyclic nitroarenes readily react with an excess of alkyl/arylthiols in the presence of DBU and bis-trimethylsilylacetamide (BSA) in DMF solution, to give dithioalkyl/aryl substituted anilines in moderate to good yields via displacement of ortho- and para-hydrogen atoms with simultaneous reduction of the nitro- to amino-group. (C) 2002 Elsevier Science Ltd. All rights reserved.